Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding

In placental malaria, interactions between parasite protein VAR2CSA and human glycosaminoglycan chondroitin sulfate A (CS) sequesters infected red blood cells in the placenta. Here, the authors provide cryo-EM structures of VAR2CSA and placental CS, identifying molecular interactions that could guid...

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Autores principales:	Kaituo Wang, Robert Dagil, Thomas Lavstsen, Sandeep K. Misra, Charlotte B. Spliid, Yong Wang, Tobias Gustavsson, Daniel R. Sandoval, Elena Ethel Vidal-Calvo, Swati Choudhary, Mette Ø Agerbaek, Kresten Lindorff-Larsen, Morten A. Nielsen, Thor G. Theander, Joshua S. Sharp, Thomas Mandel Clausen, Pontus Gourdon, Ali Salanti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fd67b0fdc13e4bbbbe14bbcaf2e9d8b8
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spelling	oai:doaj.org-article:fd67b0fdc13e4bbbbe14bbcaf2e9d8b82021-12-02T15:45:13ZCryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding10.1038/s41467-021-23254-12041-1723https://doaj.org/article/fd67b0fdc13e4bbbbe14bbcaf2e9d8b82021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23254-1https://doaj.org/toc/2041-1723In placental malaria, interactions between parasite protein VAR2CSA and human glycosaminoglycan chondroitin sulfate A (CS) sequesters infected red blood cells in the placenta. Here, the authors provide cryo-EM structures of VAR2CSA and placental CS, identifying molecular interactions that could guide design of placental malaria vaccines.Kaituo WangRobert DagilThomas LavstsenSandeep K. MisraCharlotte B. SpliidYong WangTobias GustavssonDaniel R. SandovalElena Ethel Vidal-CalvoSwati ChoudharyMette Ø AgerbaekKresten Lindorff-LarsenMorten A. NielsenThor G. TheanderJoshua S. SharpThomas Mandel ClausenPontus GourdonAli SalantiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kaituo Wang Robert Dagil Thomas Lavstsen Sandeep K. Misra Charlotte B. Spliid Yong Wang Tobias Gustavsson Daniel R. Sandoval Elena Ethel Vidal-Calvo Swati Choudhary Mette Ø Agerbaek Kresten Lindorff-Larsen Morten A. Nielsen Thor G. Theander Joshua S. Sharp Thomas Mandel Clausen Pontus Gourdon Ali Salanti Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding
description	In placental malaria, interactions between parasite protein VAR2CSA and human glycosaminoglycan chondroitin sulfate A (CS) sequesters infected red blood cells in the placenta. Here, the authors provide cryo-EM structures of VAR2CSA and placental CS, identifying molecular interactions that could guide design of placental malaria vaccines.
format	article
author	Kaituo Wang Robert Dagil Thomas Lavstsen Sandeep K. Misra Charlotte B. Spliid Yong Wang Tobias Gustavsson Daniel R. Sandoval Elena Ethel Vidal-Calvo Swati Choudhary Mette Ø Agerbaek Kresten Lindorff-Larsen Morten A. Nielsen Thor G. Theander Joshua S. Sharp Thomas Mandel Clausen Pontus Gourdon Ali Salanti
author_facet	Kaituo Wang Robert Dagil Thomas Lavstsen Sandeep K. Misra Charlotte B. Spliid Yong Wang Tobias Gustavsson Daniel R. Sandoval Elena Ethel Vidal-Calvo Swati Choudhary Mette Ø Agerbaek Kresten Lindorff-Larsen Morten A. Nielsen Thor G. Theander Joshua S. Sharp Thomas Mandel Clausen Pontus Gourdon Ali Salanti
author_sort	Kaituo Wang
title	Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding
title_short	Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding
title_full	Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding
title_fullStr	Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding
title_full_unstemmed	Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding
title_sort	cryo-em reveals the architecture of placental malaria var2csa and provides molecular insight into chondroitin sulfate binding
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fd67b0fdc13e4bbbbe14bbcaf2e9d8b8
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Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding

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