Exploratory analysis of immunization records highlights decreased SARS-CoV-2 rates in individuals with recent non-COVID-19 vaccinations

Abstract Clinical studies are ongoing to assess whether existing vaccines may afford protection against SARS-CoV-2 infection through trained immunity. In this exploratory study, we analyze immunization records from 137,037 individuals who received SARS-CoV-2 PCR tests. We find that polio, Haemophilu...

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Autores principales:	Colin Pawlowski, Arjun Puranik, Hari Bandi, A. J. Venkatakrishnan, Vineet Agarwal, Richard Kennedy, John C. O’Horo, Gregory J. Gores, Amy W. Williams, John Halamka, Andrew D. Badley, Venky Soundararajan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fd67bc36356140aaa170bb2c2ae1d4bb
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spelling	oai:doaj.org-article:fd67bc36356140aaa170bb2c2ae1d4bb2021-12-02T13:19:31ZExploratory analysis of immunization records highlights decreased SARS-CoV-2 rates in individuals with recent non-COVID-19 vaccinations10.1038/s41598-021-83641-y2045-2322https://doaj.org/article/fd67bc36356140aaa170bb2c2ae1d4bb2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83641-yhttps://doaj.org/toc/2045-2322Abstract Clinical studies are ongoing to assess whether existing vaccines may afford protection against SARS-CoV-2 infection through trained immunity. In this exploratory study, we analyze immunization records from 137,037 individuals who received SARS-CoV-2 PCR tests. We find that polio, Haemophilus influenzae type-B (HIB), measles-mumps-rubella (MMR), Varicella, pneumococcal conjugate (PCV13), Geriatric Flu, and hepatitis A/hepatitis B (HepA–HepB) vaccines administered in the past 1, 2, and 5 years are associated with decreased SARS-CoV-2 infection rates, even after adjusting for geographic SARS-CoV-2 incidence and testing rates, demographics, comorbidities, and number of other vaccinations. Furthermore, age, race/ethnicity, and blood group stratified analyses reveal significantly lower SARS-CoV-2 rate among black individuals who have taken the PCV13 vaccine, with relative risk of 0.45 at the 5 year time horizon (n: 653, 95% CI (0.32, 0.64), p-value: 6.9e−05). Overall, this study identifies existing approved vaccines which can be promising candidates for pre-clinical research and Randomized Clinical Trials towards combating COVID-19.Colin PawlowskiArjun PuranikHari BandiA. J. VenkatakrishnanVineet AgarwalRichard KennedyJohn C. O’HoroGregory J. GoresAmy W. WilliamsJohn HalamkaAndrew D. BadleyVenky SoundararajanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Colin Pawlowski Arjun Puranik Hari Bandi A. J. Venkatakrishnan Vineet Agarwal Richard Kennedy John C. O’Horo Gregory J. Gores Amy W. Williams John Halamka Andrew D. Badley Venky Soundararajan Exploratory analysis of immunization records highlights decreased SARS-CoV-2 rates in individuals with recent non-COVID-19 vaccinations
description	Abstract Clinical studies are ongoing to assess whether existing vaccines may afford protection against SARS-CoV-2 infection through trained immunity. In this exploratory study, we analyze immunization records from 137,037 individuals who received SARS-CoV-2 PCR tests. We find that polio, Haemophilus influenzae type-B (HIB), measles-mumps-rubella (MMR), Varicella, pneumococcal conjugate (PCV13), Geriatric Flu, and hepatitis A/hepatitis B (HepA–HepB) vaccines administered in the past 1, 2, and 5 years are associated with decreased SARS-CoV-2 infection rates, even after adjusting for geographic SARS-CoV-2 incidence and testing rates, demographics, comorbidities, and number of other vaccinations. Furthermore, age, race/ethnicity, and blood group stratified analyses reveal significantly lower SARS-CoV-2 rate among black individuals who have taken the PCV13 vaccine, with relative risk of 0.45 at the 5 year time horizon (n: 653, 95% CI (0.32, 0.64), p-value: 6.9e−05). Overall, this study identifies existing approved vaccines which can be promising candidates for pre-clinical research and Randomized Clinical Trials towards combating COVID-19.
format	article
author	Colin Pawlowski Arjun Puranik Hari Bandi A. J. Venkatakrishnan Vineet Agarwal Richard Kennedy John C. O’Horo Gregory J. Gores Amy W. Williams John Halamka Andrew D. Badley Venky Soundararajan
author_facet	Colin Pawlowski Arjun Puranik Hari Bandi A. J. Venkatakrishnan Vineet Agarwal Richard Kennedy John C. O’Horo Gregory J. Gores Amy W. Williams John Halamka Andrew D. Badley Venky Soundararajan
author_sort	Colin Pawlowski
title	Exploratory analysis of immunization records highlights decreased SARS-CoV-2 rates in individuals with recent non-COVID-19 vaccinations
title_short	Exploratory analysis of immunization records highlights decreased SARS-CoV-2 rates in individuals with recent non-COVID-19 vaccinations
title_full	Exploratory analysis of immunization records highlights decreased SARS-CoV-2 rates in individuals with recent non-COVID-19 vaccinations
title_fullStr	Exploratory analysis of immunization records highlights decreased SARS-CoV-2 rates in individuals with recent non-COVID-19 vaccinations
title_full_unstemmed	Exploratory analysis of immunization records highlights decreased SARS-CoV-2 rates in individuals with recent non-COVID-19 vaccinations
title_sort	exploratory analysis of immunization records highlights decreased sars-cov-2 rates in individuals with recent non-covid-19 vaccinations
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fd67bc36356140aaa170bb2c2ae1d4bb
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Exploratory analysis of immunization records highlights decreased SARS-CoV-2 rates in individuals with recent non-COVID-19 vaccinations

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