The secreted endoribonuclease ENDU-2 from the soma protects germline immortality in C. elegans

The question as to how the soma regulates the germline has been much studied. Here, the authors show in C. elegans that the poly-U specific endoribonuclease ENDU-2 is secreted from the soma and taken-up by the germline, binding mature mRNA, repressing expression of somatic transcripts and maintainin...

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Main Authors:	Wenjing Qi, Erika D. V. Gromoff, Fan Xu, Qian Zhao, Wei Yang, Dietmar Pfeifer, Wolfgang Maier, Lijiang Long, Ralf Baumeister
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/fd6af941845e499489ea04b3d6fe0d66
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spelling	oai:doaj.org-article:fd6af941845e499489ea04b3d6fe0d662021-12-02T13:34:55ZThe secreted endoribonuclease ENDU-2 from the soma protects germline immortality in C. elegans10.1038/s41467-021-21516-62041-1723https://doaj.org/article/fd6af941845e499489ea04b3d6fe0d662021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21516-6https://doaj.org/toc/2041-1723The question as to how the soma regulates the germline has been much studied. Here, the authors show in C. elegans that the poly-U specific endoribonuclease ENDU-2 is secreted from the soma and taken-up by the germline, binding mature mRNA, repressing expression of somatic transcripts and maintaining germline immortality.Wenjing QiErika D. V. GromoffFan XuQian ZhaoWei YangDietmar PfeiferWolfgang MaierLijiang LongRalf BaumeisterNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wenjing Qi Erika D. V. Gromoff Fan Xu Qian Zhao Wei Yang Dietmar Pfeifer Wolfgang Maier Lijiang Long Ralf Baumeister The secreted endoribonuclease ENDU-2 from the soma protects germline immortality in C. elegans
description	The question as to how the soma regulates the germline has been much studied. Here, the authors show in C. elegans that the poly-U specific endoribonuclease ENDU-2 is secreted from the soma and taken-up by the germline, binding mature mRNA, repressing expression of somatic transcripts and maintaining germline immortality.
format	article
author	Wenjing Qi Erika D. V. Gromoff Fan Xu Qian Zhao Wei Yang Dietmar Pfeifer Wolfgang Maier Lijiang Long Ralf Baumeister
author_facet	Wenjing Qi Erika D. V. Gromoff Fan Xu Qian Zhao Wei Yang Dietmar Pfeifer Wolfgang Maier Lijiang Long Ralf Baumeister
author_sort	Wenjing Qi
title	The secreted endoribonuclease ENDU-2 from the soma protects germline immortality in C. elegans
title_short	The secreted endoribonuclease ENDU-2 from the soma protects germline immortality in C. elegans
title_full	The secreted endoribonuclease ENDU-2 from the soma protects germline immortality in C. elegans
title_fullStr	The secreted endoribonuclease ENDU-2 from the soma protects germline immortality in C. elegans
title_full_unstemmed	The secreted endoribonuclease ENDU-2 from the soma protects germline immortality in C. elegans
title_sort	secreted endoribonuclease endu-2 from the soma protects germline immortality in c. elegans
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fd6af941845e499489ea04b3d6fe0d66
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The secreted endoribonuclease ENDU-2 from the soma protects germline immortality in C. elegans

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