HLA-A*02:07 is a protective allele for EBV negative and a susceptibility allele for EBV positive classical Hodgkin lymphoma in China.

HLA-A2 protects from EBV+ classical Hodgkin lymphoma (cHL) in Western Europe, but it is unknown whether this protective effect also exists in the Chinese population. We investigated the association of HLA-A2 and specific common and well documented HLA-A2 subtypes with EBV stratified cHL patients (n ...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xin Huang, Bouke Hepkema, Ilja Nolte, Kushi Kushekhar, Theo Jongsma, Rianne Veenstra, Sibrand Poppema, Zifen Gao, Lydia Visser, Arjan Diepstra, Anke van den Berg
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fd6c9c8dd0d242fc880a781ea4fff413
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fd6c9c8dd0d242fc880a781ea4fff413
record_format	dspace
spelling	oai:doaj.org-article:fd6c9c8dd0d242fc880a781ea4fff4132021-11-18T07:28:07ZHLA-A02:07 is a protective allele for EBV negative and a susceptibility allele for EBV positive classical Hodgkin lymphoma in China.1932-620310.1371/journal.pone.0031865https://doaj.org/article/fd6c9c8dd0d242fc880a781ea4fff4132012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22355400/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203HLA-A2 protects from EBV+ classical Hodgkin lymphoma (cHL) in Western Europe, but it is unknown whether this protective effect also exists in the Chinese population. We investigated the association of HLA-A2 and specific common and well documented HLA-A2 subtypes with EBV stratified cHL patients (n = 161) from the northern part of China. Quantitative-PCR and sequence-based subtyping was performed to identify HLA-A2 positive samples and their subtypes. 67 (42%) of the cHL patients were EBV+. There were no significant differences in percentages of HLA-A2 positivity between cHL and controls (65% vs 66%) and between EBV+ and EBV- cHL patients (70% vs 61%). The frequency distribution of HLA-A2 subtypes was significantly different between EBV stratified cHL subgroups and controls. This difference was most striking for the HLA-A02:07 type with a frequency of 38% in EBV+ cHL, 8% in EBV- cHL and 20% in controls. Significant differences were also observed for the HLA-A02:07, HLA-A2 (non-02:07) and the A2-negative typings between EBV+ cHL vs controls (p = 0.028), EBV- cHL vs controls (p = 0.045) and EBV+ vs EBV- cHL cases (p = 2×10(-5)). In conclusion, HLA-A02:07 is a predisposing allele for EBV+ cHL and a protective allele for EBV- cHL in the northern Chinese population.Xin HuangBouke HepkemaIlja NolteKushi KushekharTheo JongsmaRianne VeenstraSibrand PoppemaZifen GaoLydia VisserArjan DiepstraAnke van den BergPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 2, p e31865 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xin Huang Bouke Hepkema Ilja Nolte Kushi Kushekhar Theo Jongsma Rianne Veenstra Sibrand Poppema Zifen Gao Lydia Visser Arjan Diepstra Anke van den Berg HLA-A*02:07 is a protective allele for EBV negative and a susceptibility allele for EBV positive classical Hodgkin lymphoma in China.
description	HLA-A2 protects from EBV+ classical Hodgkin lymphoma (cHL) in Western Europe, but it is unknown whether this protective effect also exists in the Chinese population. We investigated the association of HLA-A2 and specific common and well documented HLA-A2 subtypes with EBV stratified cHL patients (n = 161) from the northern part of China. Quantitative-PCR and sequence-based subtyping was performed to identify HLA-A2 positive samples and their subtypes. 67 (42%) of the cHL patients were EBV+. There were no significant differences in percentages of HLA-A2 positivity between cHL and controls (65% vs 66%) and between EBV+ and EBV- cHL patients (70% vs 61%). The frequency distribution of HLA-A2 subtypes was significantly different between EBV stratified cHL subgroups and controls. This difference was most striking for the HLA-A02:07 type with a frequency of 38% in EBV+ cHL, 8% in EBV- cHL and 20% in controls. Significant differences were also observed for the HLA-A02:07, HLA-A2 (non-02:07) and the A2-negative typings between EBV+ cHL vs controls (p = 0.028), EBV- cHL vs controls (p = 0.045) and EBV+ vs EBV- cHL cases (p = 2×10(-5)). In conclusion, HLA-A*02:07 is a predisposing allele for EBV+ cHL and a protective allele for EBV- cHL in the northern Chinese population.
format	article
author	Xin Huang Bouke Hepkema Ilja Nolte Kushi Kushekhar Theo Jongsma Rianne Veenstra Sibrand Poppema Zifen Gao Lydia Visser Arjan Diepstra Anke van den Berg
author_facet	Xin Huang Bouke Hepkema Ilja Nolte Kushi Kushekhar Theo Jongsma Rianne Veenstra Sibrand Poppema Zifen Gao Lydia Visser Arjan Diepstra Anke van den Berg
author_sort	Xin Huang
title	HLA-A*02:07 is a protective allele for EBV negative and a susceptibility allele for EBV positive classical Hodgkin lymphoma in China.
title_short	HLA-A*02:07 is a protective allele for EBV negative and a susceptibility allele for EBV positive classical Hodgkin lymphoma in China.
title_full	HLA-A*02:07 is a protective allele for EBV negative and a susceptibility allele for EBV positive classical Hodgkin lymphoma in China.
title_fullStr	HLA-A*02:07 is a protective allele for EBV negative and a susceptibility allele for EBV positive classical Hodgkin lymphoma in China.
title_full_unstemmed	HLA-A*02:07 is a protective allele for EBV negative and a susceptibility allele for EBV positive classical Hodgkin lymphoma in China.
title_sort	hla-a*02:07 is a protective allele for ebv negative and a susceptibility allele for ebv positive classical hodgkin lymphoma in china.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/fd6c9c8dd0d242fc880a781ea4fff413
work_keys_str_mv	AT xinhuang hlaa0207isaprotectivealleleforebvnegativeandasusceptibilityalleleforebvpositiveclassicalhodgkinlymphomainchina AT boukehepkema hlaa0207isaprotectivealleleforebvnegativeandasusceptibilityalleleforebvpositiveclassicalhodgkinlymphomainchina AT iljanolte hlaa0207isaprotectivealleleforebvnegativeandasusceptibilityalleleforebvpositiveclassicalhodgkinlymphomainchina AT kushikushekhar hlaa0207isaprotectivealleleforebvnegativeandasusceptibilityalleleforebvpositiveclassicalhodgkinlymphomainchina AT theojongsma hlaa0207isaprotectivealleleforebvnegativeandasusceptibilityalleleforebvpositiveclassicalhodgkinlymphomainchina AT rianneveenstra hlaa0207isaprotectivealleleforebvnegativeandasusceptibilityalleleforebvpositiveclassicalhodgkinlymphomainchina AT sibrandpoppema hlaa0207isaprotectivealleleforebvnegativeandasusceptibilityalleleforebvpositiveclassicalhodgkinlymphomainchina AT zifengao hlaa0207isaprotectivealleleforebvnegativeandasusceptibilityalleleforebvpositiveclassicalhodgkinlymphomainchina AT lydiavisser hlaa0207isaprotectivealleleforebvnegativeandasusceptibilityalleleforebvpositiveclassicalhodgkinlymphomainchina AT arjandiepstra hlaa0207isaprotectivealleleforebvnegativeandasusceptibilityalleleforebvpositiveclassicalhodgkinlymphomainchina AT ankevandenberg hlaa0207isaprotectivealleleforebvnegativeandasusceptibilityalleleforebvpositiveclassicalhodgkinlymphomainchina
_version_	1718423450058489856

HLA-A*02:07 is a protective allele for EBV negative and a susceptibility allele for EBV positive classical Hodgkin lymphoma in China.

Ejemplares similares