Correlation Between Psoriasis Severity and Nonalcoholic Fatty Liver Disease Degree Measured Using Controlled Attenuation Parameter

Nico Gandha,1 Larisa Paramitha Wibawa,1 Tjut Nurul Alam Jacoeb,1 Andri Sanityoso Sulaiman2 1Department of Dermatology and Venereology, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta 10430, Indonesia; 2Department of Internal Medicine, Faculty of Medicine Universitas In...

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Autores principales:	Gandha N, Wibawa LP, Jacoeb TNA, Sulaiman AS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	psoriasis nonalcoholic fatty liver disease severity pasi score controlled attenuation parameter Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/fd6ddbfc59e14f5f8465768caed0a702
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spelling	oai:doaj.org-article:fd6ddbfc59e14f5f8465768caed0a7022021-12-02T13:00:50ZCorrelation Between Psoriasis Severity and Nonalcoholic Fatty Liver Disease Degree Measured Using Controlled Attenuation Parameter2230-326Xhttps://doaj.org/article/fd6ddbfc59e14f5f8465768caed0a7022020-10-01T00:00:00Zhttps://www.dovepress.com/correlation-between-psoriasis-severity-and-nonalcoholic-fatty-liver-di-peer-reviewed-article-PTThttps://doaj.org/toc/2230-326XNico Gandha,1 Larisa Paramitha Wibawa,1 Tjut Nurul Alam Jacoeb,1 Andri Sanityoso Sulaiman2 1Department of Dermatology and Venereology, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta 10430, Indonesia; 2Department of Internal Medicine, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta 10430, IndonesiaCorrespondence: Larisa Paramitha WibawaDepartment of Dermatology and Venereology, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Jl. Diponegoro No. 71, Jakarta 10430, IndonesiaTel +6221 31935383Email larisa.paramitha@ui.ac.idBackground: A growing body of evidence links psoriasis to several metabolic disorders, but the causal relationship between psoriasis and nonalcoholic fatty liver disease (NAFLD) remains understudied.Purpose: To measure the correlation between the severity of psoriasis and the degree of NAFLD.Patients and Methods: A cross-sectional study was conducted on adult patients with psoriasis in the Dermatovenereology Outpatient Clinic of Cipto Mangunkusumo Hospital from December 2017 through February 2018. Psoriasis severity (psoriasis area and severity index [PASI] and body surface area [BSA]) was recorded and compared with NAFLD degree measured by controlled attenuation parameter (CAP).Results: A total of 36 subjects were enrolled with an average age of 49.08 years (± 15.52 years). The proportions of mild, moderate, and severe psoriasis were 50%, 27.8%, and 22.2%, respectively. Median of PASI was 6.1 (2– 38.4) and BSA was 7.5 (2– 93). The proportion of NAFLD was 77.8%. The mean of the CAP score was 250.03± 45.64. There was no statistically significant correlation between psoriasis severity based on PASI and CAP score (r = 0.258; p = 0.128). However, if the degree of psoriasis was based on BSA, a significant correlation was found (r = 0.382; p = 0.021). The body mass index (BMI) and abdominal circumference were significantly correlated with CAP score (r = 0.448, p = 0.006 and r = 0.485, p = 0.003, respectively).Conclusion: Psoriasis extension correlates with NAFLD severity; further studies should assess in detail the effect of therapies on this pathophysiological link.Keywords: psoriasis, nonalcoholic fatty liver disease, severity, PASI score, controlled attenuation parameterGandha NWibawa LPJacoeb TNASulaiman ASDove Medical Pressarticlepsoriasisnonalcoholic fatty liver diseaseseveritypasi scorecontrolled attenuation parameterDermatologyRL1-803ENPsoriasis: Targets and Therapy, Vol Volume 10, Pp 39-44 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	psoriasis nonalcoholic fatty liver disease severity pasi score controlled attenuation parameter Dermatology RL1-803
spellingShingle	psoriasis nonalcoholic fatty liver disease severity pasi score controlled attenuation parameter Dermatology RL1-803 Gandha N Wibawa LP Jacoeb TNA Sulaiman AS Correlation Between Psoriasis Severity and Nonalcoholic Fatty Liver Disease Degree Measured Using Controlled Attenuation Parameter
description	Nico Gandha,1 Larisa Paramitha Wibawa,1 Tjut Nurul Alam Jacoeb,1 Andri Sanityoso Sulaiman2 1Department of Dermatology and Venereology, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta 10430, Indonesia; 2Department of Internal Medicine, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta 10430, IndonesiaCorrespondence: Larisa Paramitha WibawaDepartment of Dermatology and Venereology, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Jl. Diponegoro No. 71, Jakarta 10430, IndonesiaTel +6221 31935383Email larisa.paramitha@ui.ac.idBackground: A growing body of evidence links psoriasis to several metabolic disorders, but the causal relationship between psoriasis and nonalcoholic fatty liver disease (NAFLD) remains understudied.Purpose: To measure the correlation between the severity of psoriasis and the degree of NAFLD.Patients and Methods: A cross-sectional study was conducted on adult patients with psoriasis in the Dermatovenereology Outpatient Clinic of Cipto Mangunkusumo Hospital from December 2017 through February 2018. Psoriasis severity (psoriasis area and severity index [PASI] and body surface area [BSA]) was recorded and compared with NAFLD degree measured by controlled attenuation parameter (CAP).Results: A total of 36 subjects were enrolled with an average age of 49.08 years (± 15.52 years). The proportions of mild, moderate, and severe psoriasis were 50%, 27.8%, and 22.2%, respectively. Median of PASI was 6.1 (2– 38.4) and BSA was 7.5 (2– 93). The proportion of NAFLD was 77.8%. The mean of the CAP score was 250.03± 45.64. There was no statistically significant correlation between psoriasis severity based on PASI and CAP score (r = 0.258; p = 0.128). However, if the degree of psoriasis was based on BSA, a significant correlation was found (r = 0.382; p = 0.021). The body mass index (BMI) and abdominal circumference were significantly correlated with CAP score (r = 0.448, p = 0.006 and r = 0.485, p = 0.003, respectively).Conclusion: Psoriasis extension correlates with NAFLD severity; further studies should assess in detail the effect of therapies on this pathophysiological link.Keywords: psoriasis, nonalcoholic fatty liver disease, severity, PASI score, controlled attenuation parameter
format	article
author	Gandha N Wibawa LP Jacoeb TNA Sulaiman AS
author_facet	Gandha N Wibawa LP Jacoeb TNA Sulaiman AS
author_sort	Gandha N
title	Correlation Between Psoriasis Severity and Nonalcoholic Fatty Liver Disease Degree Measured Using Controlled Attenuation Parameter
title_short	Correlation Between Psoriasis Severity and Nonalcoholic Fatty Liver Disease Degree Measured Using Controlled Attenuation Parameter
title_full	Correlation Between Psoriasis Severity and Nonalcoholic Fatty Liver Disease Degree Measured Using Controlled Attenuation Parameter
title_fullStr	Correlation Between Psoriasis Severity and Nonalcoholic Fatty Liver Disease Degree Measured Using Controlled Attenuation Parameter
title_full_unstemmed	Correlation Between Psoriasis Severity and Nonalcoholic Fatty Liver Disease Degree Measured Using Controlled Attenuation Parameter
title_sort	correlation between psoriasis severity and nonalcoholic fatty liver disease degree measured using controlled attenuation parameter
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/fd6ddbfc59e14f5f8465768caed0a702
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Correlation Between Psoriasis Severity and Nonalcoholic Fatty Liver Disease Degree Measured Using Controlled Attenuation Parameter

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