Comprehensive characterization of claudin-low breast tumors reflects the impact of the cell-of-origin on cancer evolution

Claudin-low tumors are a rare aggressive subtype of breast cancers. In this study, the authors use a multiomics approach to demonstrate that these tumors are heterogeneous and comprise three main subgroups that emerge from different evolutionary processes.

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Detalles Bibliográficos
Autores principales:	Roxane M. Pommier, Amélien Sanlaville, Laurie Tonon, Janice Kielbassa, Emilie Thomas, Anthony Ferrari, Anne-Sophie Sertier, Frédéric Hollande, Pierre Martinez, Agnès Tissier, Anne-Pierre Morel, Maria Ouzounova, Alain Puisieux
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fd71c30afd354a149f4036cea3f453ff
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spelling	oai:doaj.org-article:fd71c30afd354a149f4036cea3f453ff2021-12-02T16:24:52ZComprehensive characterization of claudin-low breast tumors reflects the impact of the cell-of-origin on cancer evolution10.1038/s41467-020-17249-72041-1723https://doaj.org/article/fd71c30afd354a149f4036cea3f453ff2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17249-7https://doaj.org/toc/2041-1723Claudin-low tumors are a rare aggressive subtype of breast cancers. In this study, the authors use a multiomics approach to demonstrate that these tumors are heterogeneous and comprise three main subgroups that emerge from different evolutionary processes.Roxane M. PommierAmélien SanlavilleLaurie TononJanice KielbassaEmilie ThomasAnthony FerrariAnne-Sophie SertierFrédéric HollandePierre MartinezAgnès TissierAnne-Pierre MorelMaria OuzounovaAlain PuisieuxNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Roxane M. Pommier Amélien Sanlaville Laurie Tonon Janice Kielbassa Emilie Thomas Anthony Ferrari Anne-Sophie Sertier Frédéric Hollande Pierre Martinez Agnès Tissier Anne-Pierre Morel Maria Ouzounova Alain Puisieux Comprehensive characterization of claudin-low breast tumors reflects the impact of the cell-of-origin on cancer evolution
description	Claudin-low tumors are a rare aggressive subtype of breast cancers. In this study, the authors use a multiomics approach to demonstrate that these tumors are heterogeneous and comprise three main subgroups that emerge from different evolutionary processes.
format	article
author	Roxane M. Pommier Amélien Sanlaville Laurie Tonon Janice Kielbassa Emilie Thomas Anthony Ferrari Anne-Sophie Sertier Frédéric Hollande Pierre Martinez Agnès Tissier Anne-Pierre Morel Maria Ouzounova Alain Puisieux
author_facet	Roxane M. Pommier Amélien Sanlaville Laurie Tonon Janice Kielbassa Emilie Thomas Anthony Ferrari Anne-Sophie Sertier Frédéric Hollande Pierre Martinez Agnès Tissier Anne-Pierre Morel Maria Ouzounova Alain Puisieux
author_sort	Roxane M. Pommier
title	Comprehensive characterization of claudin-low breast tumors reflects the impact of the cell-of-origin on cancer evolution
title_short	Comprehensive characterization of claudin-low breast tumors reflects the impact of the cell-of-origin on cancer evolution
title_full	Comprehensive characterization of claudin-low breast tumors reflects the impact of the cell-of-origin on cancer evolution
title_fullStr	Comprehensive characterization of claudin-low breast tumors reflects the impact of the cell-of-origin on cancer evolution
title_full_unstemmed	Comprehensive characterization of claudin-low breast tumors reflects the impact of the cell-of-origin on cancer evolution
title_sort	comprehensive characterization of claudin-low breast tumors reflects the impact of the cell-of-origin on cancer evolution
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/fd71c30afd354a149f4036cea3f453ff
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Comprehensive characterization of claudin-low breast tumors reflects the impact of the cell-of-origin on cancer evolution

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