Seasonal prevalence and characteristics of low-dose CT detected lung nodules in a general Dutch population

Abstract We investigated whether presence and characteristics of lung nodules in the general population using low-dose computed tomography (LDCT) varied by season. Imaging in Lifelines (ImaLife) study participants who underwent chest LDCT-scanning between October 2018 and October 2019 were included...

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Autores principales:	Harriet L. Lancaster, Marjolein A. Heuvelmans, Gert Jan Pelgrim, Mieneke Rook, Marius G. J. Kok, Ahmed Aown, Geertruida H. de Bock, Maarten van den Berge, Harry J. M. Groen, Rozemarijn Vliegenthart
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fd74e247a2ca4daba4f0ae4425ca5d68
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spelling	oai:doaj.org-article:fd74e247a2ca4daba4f0ae4425ca5d682021-12-02T13:41:43ZSeasonal prevalence and characteristics of low-dose CT detected lung nodules in a general Dutch population10.1038/s41598-021-88328-y2045-2322https://doaj.org/article/fd74e247a2ca4daba4f0ae4425ca5d682021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88328-yhttps://doaj.org/toc/2045-2322Abstract We investigated whether presence and characteristics of lung nodules in the general population using low-dose computed tomography (LDCT) varied by season. Imaging in Lifelines (ImaLife) study participants who underwent chest LDCT-scanning between October 2018 and October 2019 were included in this sub-study. Hay fever season (summer) was defined as 1st April to 30th September and Influenza season (winter) as 1st October to 31st March. All lung nodules with volume of ≥ 30 mm3 (approximately 3 mm in diameter) were registered. In total, 2496 lung nodules were found in 1312 (38%) of the 3456 included participants (nodules per participant ranging from 1 to 21, median 1). In summer, 711 (54%) participants had 1 or more lung nodule(s) compared to 601 (46%) participants in winter (p = 0.002). Of the spherical, perifissural and left-upper-lobe nodules, relatively more were detected in winter, whereas of the polygonal-, irregular-shaped and centrally-calcified nodules, relatively more were detected in summer. Various seasonal diseases with inflammation as underlying pathophysiology may influence presence and characteristics of lung nodules. Further investigation into underlying pathophysiology using short-term LDCT follow-up could help optimize the management strategy for CT-detected lung nodules in clinical practice.Harriet L. LancasterMarjolein A. HeuvelmansGert Jan PelgrimMieneke RookMarius G. J. KokAhmed AownGeertruida H. de BockMaarten van den BergeHarry J. M. GroenRozemarijn VliegenthartNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Harriet L. Lancaster Marjolein A. Heuvelmans Gert Jan Pelgrim Mieneke Rook Marius G. J. Kok Ahmed Aown Geertruida H. de Bock Maarten van den Berge Harry J. M. Groen Rozemarijn Vliegenthart Seasonal prevalence and characteristics of low-dose CT detected lung nodules in a general Dutch population
description	Abstract We investigated whether presence and characteristics of lung nodules in the general population using low-dose computed tomography (LDCT) varied by season. Imaging in Lifelines (ImaLife) study participants who underwent chest LDCT-scanning between October 2018 and October 2019 were included in this sub-study. Hay fever season (summer) was defined as 1st April to 30th September and Influenza season (winter) as 1st October to 31st March. All lung nodules with volume of ≥ 30 mm3 (approximately 3 mm in diameter) were registered. In total, 2496 lung nodules were found in 1312 (38%) of the 3456 included participants (nodules per participant ranging from 1 to 21, median 1). In summer, 711 (54%) participants had 1 or more lung nodule(s) compared to 601 (46%) participants in winter (p = 0.002). Of the spherical, perifissural and left-upper-lobe nodules, relatively more were detected in winter, whereas of the polygonal-, irregular-shaped and centrally-calcified nodules, relatively more were detected in summer. Various seasonal diseases with inflammation as underlying pathophysiology may influence presence and characteristics of lung nodules. Further investigation into underlying pathophysiology using short-term LDCT follow-up could help optimize the management strategy for CT-detected lung nodules in clinical practice.
format	article
author	Harriet L. Lancaster Marjolein A. Heuvelmans Gert Jan Pelgrim Mieneke Rook Marius G. J. Kok Ahmed Aown Geertruida H. de Bock Maarten van den Berge Harry J. M. Groen Rozemarijn Vliegenthart
author_facet	Harriet L. Lancaster Marjolein A. Heuvelmans Gert Jan Pelgrim Mieneke Rook Marius G. J. Kok Ahmed Aown Geertruida H. de Bock Maarten van den Berge Harry J. M. Groen Rozemarijn Vliegenthart
author_sort	Harriet L. Lancaster
title	Seasonal prevalence and characteristics of low-dose CT detected lung nodules in a general Dutch population
title_short	Seasonal prevalence and characteristics of low-dose CT detected lung nodules in a general Dutch population
title_full	Seasonal prevalence and characteristics of low-dose CT detected lung nodules in a general Dutch population
title_fullStr	Seasonal prevalence and characteristics of low-dose CT detected lung nodules in a general Dutch population
title_full_unstemmed	Seasonal prevalence and characteristics of low-dose CT detected lung nodules in a general Dutch population
title_sort	seasonal prevalence and characteristics of low-dose ct detected lung nodules in a general dutch population
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fd74e247a2ca4daba4f0ae4425ca5d68
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Seasonal prevalence and characteristics of low-dose CT detected lung nodules in a general Dutch population

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