Sleep apnea and diabetes mellitus are independently associated with cardiovascular events and hospitalization for heart failure after coronary artery bypass grafting

Abstract The relative and combined effects of sleep apnea with diabetes mellitus (DM) on cardiovascular outcomes in patients undergoing coronary artery bypass grafting (CABG) remain unknown. In this secondary analysis of data from the SABOT study, 1007 patients were reclassified into four groups bas...

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Autores principales:	Aye-Thandar Aung, Chieh-Yang Koo, Wilson W. Tam, Zhengfeng Chen, William Kristanto, Hui-Wen Sim, Pipin Kojodjojo, Theodoros Kofidis, Chi-Hang Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fd79bbe7c4f241c7adda4ed43c604e95
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spelling	oai:doaj.org-article:fd79bbe7c4f241c7adda4ed43c604e952021-12-02T12:33:14ZSleep apnea and diabetes mellitus are independently associated with cardiovascular events and hospitalization for heart failure after coronary artery bypass grafting10.1038/s41598-020-78700-92045-2322https://doaj.org/article/fd79bbe7c4f241c7adda4ed43c604e952020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78700-9https://doaj.org/toc/2045-2322Abstract The relative and combined effects of sleep apnea with diabetes mellitus (DM) on cardiovascular outcomes in patients undergoing coronary artery bypass grafting (CABG) remain unknown. In this secondary analysis of data from the SABOT study, 1007 patients were reclassified into four groups based on their sleep apnea and DM statuses, yielding 295, 218, 278, and 216 patients in the sleep apnea (+) DM (+), sleep apnea (+) DM (−), sleep apnea (−) DM (+), and sleep apnea (−) DM (−) groups, respectively. After a mean follow-up period of 2.1 years, the crude incidence of major adverse cardiac and cerebrovascular event was 18% in the sleep apnea (+) DM (+), 11% in the sleep apnea (+) DM (−), 13% in the sleep apnea (−) DM (+), and 5% in the sleep apnea (−) DM (−) groups. Using sleep apnea (−) DM (−) as the reference group, a Cox regression analysis indicated that sleep apnea (+) and DM (+) independently predicted MACCEs (adjusted hazard ratio, 3.2; 95% confidence interval, 1.7–6.2; p = 0.005) and hospitalization for heart failure (adjusted hazard ratio, 12.6; 95% confidence interval, 3.0–52.3; p < 0.001). Sleep apnea and DM have independent effects on the prognosis of patients undergoing CABG. Clinical trial registration: ClinicalTrials.gov identification no. NCT02701504.Aye-Thandar AungChieh-Yang KooWilson W. TamZhengfeng ChenWilliam KristantoHui-Wen SimPipin KojodjojoTheodoros KofidisChi-Hang LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Aye-Thandar Aung Chieh-Yang Koo Wilson W. Tam Zhengfeng Chen William Kristanto Hui-Wen Sim Pipin Kojodjojo Theodoros Kofidis Chi-Hang Lee Sleep apnea and diabetes mellitus are independently associated with cardiovascular events and hospitalization for heart failure after coronary artery bypass grafting
description	Abstract The relative and combined effects of sleep apnea with diabetes mellitus (DM) on cardiovascular outcomes in patients undergoing coronary artery bypass grafting (CABG) remain unknown. In this secondary analysis of data from the SABOT study, 1007 patients were reclassified into four groups based on their sleep apnea and DM statuses, yielding 295, 218, 278, and 216 patients in the sleep apnea (+) DM (+), sleep apnea (+) DM (−), sleep apnea (−) DM (+), and sleep apnea (−) DM (−) groups, respectively. After a mean follow-up period of 2.1 years, the crude incidence of major adverse cardiac and cerebrovascular event was 18% in the sleep apnea (+) DM (+), 11% in the sleep apnea (+) DM (−), 13% in the sleep apnea (−) DM (+), and 5% in the sleep apnea (−) DM (−) groups. Using sleep apnea (−) DM (−) as the reference group, a Cox regression analysis indicated that sleep apnea (+) and DM (+) independently predicted MACCEs (adjusted hazard ratio, 3.2; 95% confidence interval, 1.7–6.2; p = 0.005) and hospitalization for heart failure (adjusted hazard ratio, 12.6; 95% confidence interval, 3.0–52.3; p < 0.001). Sleep apnea and DM have independent effects on the prognosis of patients undergoing CABG. Clinical trial registration: ClinicalTrials.gov identification no. NCT02701504.
format	article
author	Aye-Thandar Aung Chieh-Yang Koo Wilson W. Tam Zhengfeng Chen William Kristanto Hui-Wen Sim Pipin Kojodjojo Theodoros Kofidis Chi-Hang Lee
author_facet	Aye-Thandar Aung Chieh-Yang Koo Wilson W. Tam Zhengfeng Chen William Kristanto Hui-Wen Sim Pipin Kojodjojo Theodoros Kofidis Chi-Hang Lee
author_sort	Aye-Thandar Aung
title	Sleep apnea and diabetes mellitus are independently associated with cardiovascular events and hospitalization for heart failure after coronary artery bypass grafting
title_short	Sleep apnea and diabetes mellitus are independently associated with cardiovascular events and hospitalization for heart failure after coronary artery bypass grafting
title_full	Sleep apnea and diabetes mellitus are independently associated with cardiovascular events and hospitalization for heart failure after coronary artery bypass grafting
title_fullStr	Sleep apnea and diabetes mellitus are independently associated with cardiovascular events and hospitalization for heart failure after coronary artery bypass grafting
title_full_unstemmed	Sleep apnea and diabetes mellitus are independently associated with cardiovascular events and hospitalization for heart failure after coronary artery bypass grafting
title_sort	sleep apnea and diabetes mellitus are independently associated with cardiovascular events and hospitalization for heart failure after coronary artery bypass grafting
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/fd79bbe7c4f241c7adda4ed43c604e95
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Sleep apnea and diabetes mellitus are independently associated with cardiovascular events and hospitalization for heart failure after coronary artery bypass grafting

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