Structural and Molecular Basis for Resistance to Aminoglycoside Antibiotics by the Adenylyltransferase ANT(2″)-Ia
ABSTRACT The aminoglycosides are highly effective broad-spectrum antimicrobial agents. However, their efficacy is diminished due to enzyme-mediated covalent modification, which reduces affinity of the drug for the target ribosome. One of the most prevalent aminoglycoside resistance enzymes in Gram...
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Autores principales: | Georgina Cox, Peter J. Stogios, Alexei Savchenko, Gerard D. Wright |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
American Society for Microbiology
2015
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Materias: | |
Acceso en línea: | https://doaj.org/article/fd7bf175aab344249426cb45b5b3ac71 |
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