Feeding diversified protein sources exacerbates hepatic insulin resistance via increased gut microbial branched-chain fatty acids and mTORC1 signaling in obese mice

Feeding diversified protein sources exacerbates hepatic insulin resistance via increased gut microbial branched-chain fatty acids and mTORC1 signaling in obese mice

Diet-induced changes in the microbiome have been associated with obesity. Here, using a mouse model, the authors show that a mixed protein source found in western diets exacerbates diet-induced obesity and insulin resistance by potentiating hepatic mTORC1/S6K1 signaling via microbial production of b...

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Autores principales: Béatrice S.-Y. Choi, Noëmie Daniel, Vanessa P. Houde, Adia Ouellette, Bruno Marcotte, Thibault V. Varin, Cécile Vors, Perrine Feutry, Olga Ilkayeva, Marcus Ståhlman, Philippe St-Pierre, Fredrik Bäckhed, Angelo Tremblay, Phillip J. White, André Marette
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/fd7e575509cd4ed1a49d204ec6f5f9de
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spelling oai:doaj.org-article:fd7e575509cd4ed1a49d204ec6f5f9de2021-12-02T17:52:08ZFeeding diversified protein sources exacerbates hepatic insulin resistance via increased gut microbial branched-chain fatty acids and mTORC1 signaling in obese mice10.1038/s41467-021-23782-w2041-1723https://doaj.org/article/fd7e575509cd4ed1a49d204ec6f5f9de2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23782-whttps://doaj.org/toc/2041-1723Diet-induced changes in the microbiome have been associated with obesity. Here, using a mouse model, the authors show that a mixed protein source found in western diets exacerbates diet-induced obesity and insulin resistance by potentiating hepatic mTORC1/S6K1 signaling via microbial production of branched-chain fatty acids (BCFA).Béatrice S.-Y. ChoiNoëmie DanielVanessa P. HoudeAdia OuelletteBruno MarcotteThibault V. VarinCécile VorsPerrine FeutryOlga IlkayevaMarcus StåhlmanPhilippe St-PierreFredrik BäckhedAngelo TremblayPhillip J. WhiteAndré MaretteNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Béatrice S.-Y. Choi
Noëmie Daniel
Vanessa P. Houde
Adia Ouellette
Bruno Marcotte
Thibault V. Varin
Cécile Vors
Perrine Feutry
Olga Ilkayeva
Marcus Ståhlman
Philippe St-Pierre
Fredrik Bäckhed
Angelo Tremblay
Phillip J. White
André Marette
Feeding diversified protein sources exacerbates hepatic insulin resistance via increased gut microbial branched-chain fatty acids and mTORC1 signaling in obese mice
description Diet-induced changes in the microbiome have been associated with obesity. Here, using a mouse model, the authors show that a mixed protein source found in western diets exacerbates diet-induced obesity and insulin resistance by potentiating hepatic mTORC1/S6K1 signaling via microbial production of branched-chain fatty acids (BCFA).
format article
author Béatrice S.-Y. Choi
Noëmie Daniel
Vanessa P. Houde
Adia Ouellette
Bruno Marcotte
Thibault V. Varin
Cécile Vors
Perrine Feutry
Olga Ilkayeva
Marcus Ståhlman
Philippe St-Pierre
Fredrik Bäckhed
Angelo Tremblay
Phillip J. White
André Marette
author_facet Béatrice S.-Y. Choi
Noëmie Daniel
Vanessa P. Houde
Adia Ouellette
Bruno Marcotte
Thibault V. Varin
Cécile Vors
Perrine Feutry
Olga Ilkayeva
Marcus Ståhlman
Philippe St-Pierre
Fredrik Bäckhed
Angelo Tremblay
Phillip J. White
André Marette
author_sort Béatrice S.-Y. Choi
title Feeding diversified protein sources exacerbates hepatic insulin resistance via increased gut microbial branched-chain fatty acids and mTORC1 signaling in obese mice
title_short Feeding diversified protein sources exacerbates hepatic insulin resistance via increased gut microbial branched-chain fatty acids and mTORC1 signaling in obese mice
title_full Feeding diversified protein sources exacerbates hepatic insulin resistance via increased gut microbial branched-chain fatty acids and mTORC1 signaling in obese mice
title_fullStr Feeding diversified protein sources exacerbates hepatic insulin resistance via increased gut microbial branched-chain fatty acids and mTORC1 signaling in obese mice
title_full_unstemmed Feeding diversified protein sources exacerbates hepatic insulin resistance via increased gut microbial branched-chain fatty acids and mTORC1 signaling in obese mice
title_sort feeding diversified protein sources exacerbates hepatic insulin resistance via increased gut microbial branched-chain fatty acids and mtorc1 signaling in obese mice
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/fd7e575509cd4ed1a49d204ec6f5f9de
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