Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling

Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling

Angiotensin II type 1 receptor (AT1R)-mediated acute catecholamine release is modulated by β-arrestin. Here the authors show that β-arrestin-1 recruits the Ca2+channel TRPC3 and the PLCγ to the AT1R-β-arrestin complex, triggering G protein-independent calcium influx and catecholamine secretion.

Guardado en:
Detalles Bibliográficos
Autores principales: Chun-Hua Liu, Zheng Gong, Zong-Lai Liang, Zhi-Xin Liu, Fan Yang, Yu-Jing Sun, Ming-Liang Ma, Yi-Jing Wang, Chao-Ran Ji, Yu-Hong Wang, Mei-Jie Wang, Fu-Ai Cui, Amy Lin, Wen-Shuai Zheng, Dong-Fang He, Chang-xiu Qu, Peng Xiao, Chuan-Yong Liu, Alex R. B. Thomsen, Thomas Joseph Cahill, Alem W. Kahsai, Fan Yi, Kun-Hong Xiao, Tian Xue, Zhuan Zhou, Xiao Yu, Jin-Peng Sun
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/fd8251bd4bfc4bada3441c9bdef9e02e
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:fd8251bd4bfc4bada3441c9bdef9e02e
record_format dspace
spelling oai:doaj.org-article:fd8251bd4bfc4bada3441c9bdef9e02e2021-12-02T14:41:19ZArrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling10.1038/ncomms143352041-1723https://doaj.org/article/fd8251bd4bfc4bada3441c9bdef9e02e2017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14335https://doaj.org/toc/2041-1723Angiotensin II type 1 receptor (AT1R)-mediated acute catecholamine release is modulated by β-arrestin. Here the authors show that β-arrestin-1 recruits the Ca2+channel TRPC3 and the PLCγ to the AT1R-β-arrestin complex, triggering G protein-independent calcium influx and catecholamine secretion.Chun-Hua LiuZheng GongZong-Lai LiangZhi-Xin LiuFan YangYu-Jing SunMing-Liang MaYi-Jing WangChao-Ran JiYu-Hong WangMei-Jie WangFu-Ai CuiAmy LinWen-Shuai ZhengDong-Fang HeChang-xiu QuPeng XiaoChuan-Yong LiuAlex R. B. ThomsenThomas Joseph CahillAlem W. KahsaiFan YiKun-Hong XiaoTian XueZhuan ZhouXiao YuJin-Peng SunNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Chun-Hua Liu
Zheng Gong
Zong-Lai Liang
Zhi-Xin Liu
Fan Yang
Yu-Jing Sun
Ming-Liang Ma
Yi-Jing Wang
Chao-Ran Ji
Yu-Hong Wang
Mei-Jie Wang
Fu-Ai Cui
Amy Lin
Wen-Shuai Zheng
Dong-Fang He
Chang-xiu Qu
Peng Xiao
Chuan-Yong Liu
Alex R. B. Thomsen
Thomas Joseph Cahill
Alem W. Kahsai
Fan Yi
Kun-Hong Xiao
Tian Xue
Zhuan Zhou
Xiao Yu
Jin-Peng Sun
Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling
description Angiotensin II type 1 receptor (AT1R)-mediated acute catecholamine release is modulated by β-arrestin. Here the authors show that β-arrestin-1 recruits the Ca2+channel TRPC3 and the PLCγ to the AT1R-β-arrestin complex, triggering G protein-independent calcium influx and catecholamine secretion.
format article
author Chun-Hua Liu
Zheng Gong
Zong-Lai Liang
Zhi-Xin Liu
Fan Yang
Yu-Jing Sun
Ming-Liang Ma
Yi-Jing Wang
Chao-Ran Ji
Yu-Hong Wang
Mei-Jie Wang
Fu-Ai Cui
Amy Lin
Wen-Shuai Zheng
Dong-Fang He
Chang-xiu Qu
Peng Xiao
Chuan-Yong Liu
Alex R. B. Thomsen
Thomas Joseph Cahill
Alem W. Kahsai
Fan Yi
Kun-Hong Xiao
Tian Xue
Zhuan Zhou
Xiao Yu
Jin-Peng Sun
author_facet Chun-Hua Liu
Zheng Gong
Zong-Lai Liang
Zhi-Xin Liu
Fan Yang
Yu-Jing Sun
Ming-Liang Ma
Yi-Jing Wang
Chao-Ran Ji
Yu-Hong Wang
Mei-Jie Wang
Fu-Ai Cui
Amy Lin
Wen-Shuai Zheng
Dong-Fang He
Chang-xiu Qu
Peng Xiao
Chuan-Yong Liu
Alex R. B. Thomsen
Thomas Joseph Cahill
Alem W. Kahsai
Fan Yi
Kun-Hong Xiao
Tian Xue
Zhuan Zhou
Xiao Yu
Jin-Peng Sun
author_sort Chun-Hua Liu
title Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling
title_short Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling
title_full Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling
title_fullStr Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling
title_full_unstemmed Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling
title_sort arrestin-biased at1r agonism induces acute catecholamine secretion through trpc3 coupling
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/fd8251bd4bfc4bada3441c9bdef9e02e
work_keys_str_mv AT chunhualiu arrestinbiasedat1ragonisminducesacutecatecholaminesecretionthroughtrpc3coupling
AT zhenggong arrestinbiasedat1ragonisminducesacutecatecholaminesecretionthroughtrpc3coupling
AT zonglailiang arrestinbiasedat1ragonisminducesacutecatecholaminesecretionthroughtrpc3coupling
AT zhixinliu arrestinbiasedat1ragonisminducesacutecatecholaminesecretionthroughtrpc3coupling
AT fanyang arrestinbiasedat1ragonisminducesacutecatecholaminesecretionthroughtrpc3coupling
AT yujingsun arrestinbiasedat1ragonisminducesacutecatecholaminesecretionthroughtrpc3coupling
AT mingliangma arrestinbiasedat1ragonisminducesacutecatecholaminesecretionthroughtrpc3coupling
AT yijingwang arrestinbiasedat1ragonisminducesacutecatecholaminesecretionthroughtrpc3coupling
AT chaoranji arrestinbiasedat1ragonisminducesacutecatecholaminesecretionthroughtrpc3coupling
AT yuhongwang arrestinbiasedat1ragonisminducesacutecatecholaminesecretionthroughtrpc3coupling
AT meijiewang arrestinbiasedat1ragonisminducesacutecatecholaminesecretionthroughtrpc3coupling
AT fuaicui arrestinbiasedat1ragonisminducesacutecatecholaminesecretionthroughtrpc3coupling
AT amylin arrestinbiasedat1ragonisminducesacutecatecholaminesecretionthroughtrpc3coupling
AT wenshuaizheng arrestinbiasedat1ragonisminducesacutecatecholaminesecretionthroughtrpc3coupling
AT dongfanghe arrestinbiasedat1ragonisminducesacutecatecholaminesecretionthroughtrpc3coupling
AT changxiuqu arrestinbiasedat1ragonisminducesacutecatecholaminesecretionthroughtrpc3coupling
AT pengxiao arrestinbiasedat1ragonisminducesacutecatecholaminesecretionthroughtrpc3coupling
AT chuanyongliu arrestinbiasedat1ragonisminducesacutecatecholaminesecretionthroughtrpc3coupling
AT alexrbthomsen arrestinbiasedat1ragonisminducesacutecatecholaminesecretionthroughtrpc3coupling
AT thomasjosephcahill arrestinbiasedat1ragonisminducesacutecatecholaminesecretionthroughtrpc3coupling
AT alemwkahsai arrestinbiasedat1ragonisminducesacutecatecholaminesecretionthroughtrpc3coupling
AT fanyi arrestinbiasedat1ragonisminducesacutecatecholaminesecretionthroughtrpc3coupling
AT kunhongxiao arrestinbiasedat1ragonisminducesacutecatecholaminesecretionthroughtrpc3coupling
AT tianxue arrestinbiasedat1ragonisminducesacutecatecholaminesecretionthroughtrpc3coupling
AT zhuanzhou arrestinbiasedat1ragonisminducesacutecatecholaminesecretionthroughtrpc3coupling
AT xiaoyu arrestinbiasedat1ragonisminducesacutecatecholaminesecretionthroughtrpc3coupling
AT jinpengsun arrestinbiasedat1ragonisminducesacutecatecholaminesecretionthroughtrpc3coupling
_version_ 1718389969360257024

Ejemplares similares