The small GTPase Rheb affects central brain neuronal morphology and memory formation in Drosophila.

Mutations in either of two tumor suppressor genes, TSC1 or TSC2, cause tuberous sclerosis complex (TSC), a syndrome resulting in benign hamartomatous tumors and neurological disorders. Cellular growth defects and neuronal disorganization associated with TSC are believed to be due to upregulated TOR...

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Autores principales:	Heather L D Brown, Karla R Kaun, Bruce A Edgar
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fd843a34af0f4aec8908c40bea69ca89
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spelling	oai:doaj.org-article:fd843a34af0f4aec8908c40bea69ca892021-11-18T07:04:58ZThe small GTPase Rheb affects central brain neuronal morphology and memory formation in Drosophila.1932-620310.1371/journal.pone.0044888https://doaj.org/article/fd843a34af0f4aec8908c40bea69ca892012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23028662/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Mutations in either of two tumor suppressor genes, TSC1 or TSC2, cause tuberous sclerosis complex (TSC), a syndrome resulting in benign hamartomatous tumors and neurological disorders. Cellular growth defects and neuronal disorganization associated with TSC are believed to be due to upregulated TOR signaling. We overexpressed Rheb, an upstream regulator of TOR, in two different subsets of D. melanogaster central brain neurons in order to upregulate the Tsc-Rheb-TOR pathway. Overexpression of Rheb in either the mushroom bodies or the insulin producing cells resulted in enlarged axon projections and cell bodies, which continued to increase in size with prolonged Rheb expression as the animals aged. Additionally, Rheb overexpression in the mushroom bodies resulted in deficiencies in 3 hr but not immediate appetitive memory. Thus, Rheb overexpression in the central brain neurons of flies causes not only morphological phenotypes, but behavioral and aging phenotypes that may mirror symptoms of TSC.Heather L D BrownKarla R KaunBruce A EdgarPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 9, p e44888 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Heather L D Brown Karla R Kaun Bruce A Edgar The small GTPase Rheb affects central brain neuronal morphology and memory formation in Drosophila.
description	Mutations in either of two tumor suppressor genes, TSC1 or TSC2, cause tuberous sclerosis complex (TSC), a syndrome resulting in benign hamartomatous tumors and neurological disorders. Cellular growth defects and neuronal disorganization associated with TSC are believed to be due to upregulated TOR signaling. We overexpressed Rheb, an upstream regulator of TOR, in two different subsets of D. melanogaster central brain neurons in order to upregulate the Tsc-Rheb-TOR pathway. Overexpression of Rheb in either the mushroom bodies or the insulin producing cells resulted in enlarged axon projections and cell bodies, which continued to increase in size with prolonged Rheb expression as the animals aged. Additionally, Rheb overexpression in the mushroom bodies resulted in deficiencies in 3 hr but not immediate appetitive memory. Thus, Rheb overexpression in the central brain neurons of flies causes not only morphological phenotypes, but behavioral and aging phenotypes that may mirror symptoms of TSC.
format	article
author	Heather L D Brown Karla R Kaun Bruce A Edgar
author_facet	Heather L D Brown Karla R Kaun Bruce A Edgar
author_sort	Heather L D Brown
title	The small GTPase Rheb affects central brain neuronal morphology and memory formation in Drosophila.
title_short	The small GTPase Rheb affects central brain neuronal morphology and memory formation in Drosophila.
title_full	The small GTPase Rheb affects central brain neuronal morphology and memory formation in Drosophila.
title_fullStr	The small GTPase Rheb affects central brain neuronal morphology and memory formation in Drosophila.
title_full_unstemmed	The small GTPase Rheb affects central brain neuronal morphology and memory formation in Drosophila.
title_sort	small gtpase rheb affects central brain neuronal morphology and memory formation in drosophila.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/fd843a34af0f4aec8908c40bea69ca89
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The small GTPase Rheb affects central brain neuronal morphology and memory formation in Drosophila.

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