Neuroepigenetic signatures of age and sex in the living human brain
Gene transcription is known to vary with age and sex, although the underlying mechanisms are unresolved. Here, the authors show that epigenetic enzymes known as HDACs, which regulate gene transcription, are increasingly expressed with age in the living human brain, with sex differences also observed...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2019
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/fd891fe0074148ad83476fb18c8b1d21 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:fd891fe0074148ad83476fb18c8b1d21 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:fd891fe0074148ad83476fb18c8b1d212021-12-02T17:32:23ZNeuroepigenetic signatures of age and sex in the living human brain10.1038/s41467-019-11031-02041-1723https://doaj.org/article/fd891fe0074148ad83476fb18c8b1d212019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11031-0https://doaj.org/toc/2041-1723Gene transcription is known to vary with age and sex, although the underlying mechanisms are unresolved. Here, the authors show that epigenetic enzymes known as HDACs, which regulate gene transcription, are increasingly expressed with age in the living human brain, with sex differences also observed.Tonya M. GilbertNicole R. ZürcherMary C. CataneseChieh-En J. TsengMaria A. Di BiaseAmanda E. LyallBaileigh G. HightowerAnjali J. ParmarAnisha BhanotChristine J. WuMatthew L. HibertMinhae KimUmar MahmoodSteven M. StufflebeamFrederick A. SchroederChangning WangJoshua L. RoffmanDaphne J. HoltDouglas N. GreveOfer PasternakMarek KubickiHsiao-Ying WeyJacob M. HookerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Tonya M. Gilbert Nicole R. Zürcher Mary C. Catanese Chieh-En J. Tseng Maria A. Di Biase Amanda E. Lyall Baileigh G. Hightower Anjali J. Parmar Anisha Bhanot Christine J. Wu Matthew L. Hibert Minhae Kim Umar Mahmood Steven M. Stufflebeam Frederick A. Schroeder Changning Wang Joshua L. Roffman Daphne J. Holt Douglas N. Greve Ofer Pasternak Marek Kubicki Hsiao-Ying Wey Jacob M. Hooker Neuroepigenetic signatures of age and sex in the living human brain |
| description |
Gene transcription is known to vary with age and sex, although the underlying mechanisms are unresolved. Here, the authors show that epigenetic enzymes known as HDACs, which regulate gene transcription, are increasingly expressed with age in the living human brain, with sex differences also observed. |
| format |
article |
| author |
Tonya M. Gilbert Nicole R. Zürcher Mary C. Catanese Chieh-En J. Tseng Maria A. Di Biase Amanda E. Lyall Baileigh G. Hightower Anjali J. Parmar Anisha Bhanot Christine J. Wu Matthew L. Hibert Minhae Kim Umar Mahmood Steven M. Stufflebeam Frederick A. Schroeder Changning Wang Joshua L. Roffman Daphne J. Holt Douglas N. Greve Ofer Pasternak Marek Kubicki Hsiao-Ying Wey Jacob M. Hooker |
| author_facet |
Tonya M. Gilbert Nicole R. Zürcher Mary C. Catanese Chieh-En J. Tseng Maria A. Di Biase Amanda E. Lyall Baileigh G. Hightower Anjali J. Parmar Anisha Bhanot Christine J. Wu Matthew L. Hibert Minhae Kim Umar Mahmood Steven M. Stufflebeam Frederick A. Schroeder Changning Wang Joshua L. Roffman Daphne J. Holt Douglas N. Greve Ofer Pasternak Marek Kubicki Hsiao-Ying Wey Jacob M. Hooker |
| author_sort |
Tonya M. Gilbert |
| title |
Neuroepigenetic signatures of age and sex in the living human brain |
| title_short |
Neuroepigenetic signatures of age and sex in the living human brain |
| title_full |
Neuroepigenetic signatures of age and sex in the living human brain |
| title_fullStr |
Neuroepigenetic signatures of age and sex in the living human brain |
| title_full_unstemmed |
Neuroepigenetic signatures of age and sex in the living human brain |
| title_sort |
neuroepigenetic signatures of age and sex in the living human brain |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/fd891fe0074148ad83476fb18c8b1d21 |
| work_keys_str_mv |
AT tonyamgilbert neuroepigeneticsignaturesofageandsexinthelivinghumanbrain AT nicolerzurcher neuroepigeneticsignaturesofageandsexinthelivinghumanbrain AT maryccatanese neuroepigeneticsignaturesofageandsexinthelivinghumanbrain AT chiehenjtseng neuroepigeneticsignaturesofageandsexinthelivinghumanbrain AT mariaadibiase neuroepigeneticsignaturesofageandsexinthelivinghumanbrain AT amandaelyall neuroepigeneticsignaturesofageandsexinthelivinghumanbrain AT baileighghightower neuroepigeneticsignaturesofageandsexinthelivinghumanbrain AT anjalijparmar neuroepigeneticsignaturesofageandsexinthelivinghumanbrain AT anishabhanot neuroepigeneticsignaturesofageandsexinthelivinghumanbrain AT christinejwu neuroepigeneticsignaturesofageandsexinthelivinghumanbrain AT matthewlhibert neuroepigeneticsignaturesofageandsexinthelivinghumanbrain AT minhaekim neuroepigeneticsignaturesofageandsexinthelivinghumanbrain AT umarmahmood neuroepigeneticsignaturesofageandsexinthelivinghumanbrain AT stevenmstufflebeam neuroepigeneticsignaturesofageandsexinthelivinghumanbrain AT frederickaschroeder neuroepigeneticsignaturesofageandsexinthelivinghumanbrain AT changningwang neuroepigeneticsignaturesofageandsexinthelivinghumanbrain AT joshualroffman neuroepigeneticsignaturesofageandsexinthelivinghumanbrain AT daphnejholt neuroepigeneticsignaturesofageandsexinthelivinghumanbrain AT douglasngreve neuroepigeneticsignaturesofageandsexinthelivinghumanbrain AT oferpasternak neuroepigeneticsignaturesofageandsexinthelivinghumanbrain AT marekkubicki neuroepigeneticsignaturesofageandsexinthelivinghumanbrain AT hsiaoyingwey neuroepigeneticsignaturesofageandsexinthelivinghumanbrain AT jacobmhooker neuroepigeneticsignaturesofageandsexinthelivinghumanbrain |
| _version_ |
1718380346970472448 |