Effect of once-daily FDC treatment era on initiation of cART

David M Mosen1, Michael Horberg2, Douglas Roblin3, Christina M Gullion1, Richard Meenan1, Wendy Leyden2, Weiming Hu11Center for Health Research, Kaiser Permanente Northwest, Portland, OR, USA; 2Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA; 3Center for Health Research...

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Autores principales:	David M Mosen, Michael Horberg, Douglas Roblin, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/fd8c89ed7cbc4950aa8bf2d39f66cba0
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spelling	oai:doaj.org-article:fd8c89ed7cbc4950aa8bf2d39f66cba02021-12-02T00:21:58ZEffect of once-daily FDC treatment era on initiation of cART1179-1373https://doaj.org/article/fd8c89ed7cbc4950aa8bf2d39f66cba02010-02-01T00:00:00Zhttp://www.dovepress.com/effect-of-once-daily-fdc-treatment-era-on-initiation-of-cart-a3967https://doaj.org/toc/1179-1373David M Mosen1, Michael Horberg2, Douglas Roblin3, Christina M Gullion1, Richard Meenan1, Wendy Leyden2, Weiming Hu11Center for Health Research, Kaiser Permanente Northwest, Portland, OR, USA; 2Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA; 3Center for Health Research, Kaiser Permanente Georgia, Atlanta, GA, USAObjectives: Combination antiretroviral therapy (cART) is associated with increased survival among HIV-infected persons. Yet, no research to date has examined whether introduction of once-daily fixed-dosed combinations (FDC) affects the likelihood of cART initiation. We aimed to determine whether implementation of once-daily FDC regimens was associated with changes to cART initiation. We also identified clinical, treatment regimen, and provider characteristics possibly associated with cART initiation. Study design: Retrospective observational analysis.Methods: We queried electronic medical records between July 1999&ndash;June 2006 to identify incident cases of detectable HIV infection in antiretroviral-na&iuml;ve adults. Cox regression with time-dependent covariates was used to examine the effects of once-daily FDC era, clinical, provider, and treatment regimen characteristics on cART initiation.Results: Once-daily FDC availability did not change the likelihood of cART initiation, but other characteristics were associated with an increased likelihood: AIDS diagnosis, above-median daily pill consumption, and 16+ yrs of physician HIV experience. Decreased likelihood of cART initiation was associated with CD4 201&ndash;350 cells/&micro;L, HIV RNA &lt; 100,000 copies/mL, and with CD4 &gt; 350 cells/&micro;L (any HIV RNA level), compared to CD4 &le; 200 cells/&micro;L.Conclusion: Availability of once-daily FDC-based regimens did not affect likelihood of cART initiation. Patient clinical characteristics appear to be more important predictors of cART initiation.Keywords: ARV treatment, once-daily FDC therapies, ARV-na&iuml;ve David M MosenMichael HorbergDouglas Roblinet alDove Medical PressarticleImmunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol 2010, Iss default, Pp 19-26 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607
spellingShingle	Immunologic diseases. Allergy RC581-607 David M Mosen Michael Horberg Douglas Roblin et al Effect of once-daily FDC treatment era on initiation of cART
description	David M Mosen1, Michael Horberg2, Douglas Roblin3, Christina M Gullion1, Richard Meenan1, Wendy Leyden2, Weiming Hu11Center for Health Research, Kaiser Permanente Northwest, Portland, OR, USA; 2Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA; 3Center for Health Research, Kaiser Permanente Georgia, Atlanta, GA, USAObjectives: Combination antiretroviral therapy (cART) is associated with increased survival among HIV-infected persons. Yet, no research to date has examined whether introduction of once-daily fixed-dosed combinations (FDC) affects the likelihood of cART initiation. We aimed to determine whether implementation of once-daily FDC regimens was associated with changes to cART initiation. We also identified clinical, treatment regimen, and provider characteristics possibly associated with cART initiation. Study design: Retrospective observational analysis.Methods: We queried electronic medical records between July 1999&ndash;June 2006 to identify incident cases of detectable HIV infection in antiretroviral-na&iuml;ve adults. Cox regression with time-dependent covariates was used to examine the effects of once-daily FDC era, clinical, provider, and treatment regimen characteristics on cART initiation.Results: Once-daily FDC availability did not change the likelihood of cART initiation, but other characteristics were associated with an increased likelihood: AIDS diagnosis, above-median daily pill consumption, and 16+ yrs of physician HIV experience. Decreased likelihood of cART initiation was associated with CD4 201&ndash;350 cells/&micro;L, HIV RNA &lt; 100,000 copies/mL, and with CD4 &gt; 350 cells/&micro;L (any HIV RNA level), compared to CD4 &le; 200 cells/&micro;L.Conclusion: Availability of once-daily FDC-based regimens did not affect likelihood of cART initiation. Patient clinical characteristics appear to be more important predictors of cART initiation.Keywords: ARV treatment, once-daily FDC therapies, ARV-na&iuml;ve
format	article
author	David M Mosen Michael Horberg Douglas Roblin et al
author_facet	David M Mosen Michael Horberg Douglas Roblin et al
author_sort	David M Mosen
title	Effect of once-daily FDC treatment era on initiation of cART
title_short	Effect of once-daily FDC treatment era on initiation of cART
title_full	Effect of once-daily FDC treatment era on initiation of cART
title_fullStr	Effect of once-daily FDC treatment era on initiation of cART
title_full_unstemmed	Effect of once-daily FDC treatment era on initiation of cART
title_sort	effect of once-daily fdc treatment era on initiation of cart
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/fd8c89ed7cbc4950aa8bf2d39f66cba0
work_keys_str_mv	AT davidmmosen effectofoncedailyfdctreatmenteraoninitiationofcart AT michaelhorberg effectofoncedailyfdctreatmenteraoninitiationofcart AT douglasroblin effectofoncedailyfdctreatmenteraoninitiationofcart AT etal effectofoncedailyfdctreatmenteraoninitiationofcart
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Effect of once-daily FDC treatment era on initiation of cART

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