Plasma lipidomic profiling of treated HIV-positive individuals and the implications for cardiovascular risk prediction.

<h4>Background</h4>The increased risk of coronary artery disease in human immunodeficiency virus (HIV) positive patients is collectively contributed to by the human immunodeficiency virus and antiretroviral-associated dyslipidaemia. In this study, we investigate the characterisation of t...

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Autores principales:	Gerard Wong, Janine M Trevillyan, Benoit Fatou, Michelle Cinel, Jacquelyn M Weir, Jennifer F Hoy, Peter J Meikle
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fd8ddb8c6e0d44c9a9055717e391bad9
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spelling	oai:doaj.org-article:fd8ddb8c6e0d44c9a9055717e391bad92021-11-18T08:23:21ZPlasma lipidomic profiling of treated HIV-positive individuals and the implications for cardiovascular risk prediction.1932-620310.1371/journal.pone.0094810https://doaj.org/article/fd8ddb8c6e0d44c9a9055717e391bad92014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24733512/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The increased risk of coronary artery disease in human immunodeficiency virus (HIV) positive patients is collectively contributed to by the human immunodeficiency virus and antiretroviral-associated dyslipidaemia. In this study, we investigate the characterisation of the plasma lipid profiles of treated HIV patients and the relationship of 316 plasma lipid species across multiple lipid classes with the risk of future cardiovascular events in HIV-positive patients.<h4>Methods</h4>In a retrospective case-control study, we analysed plasma lipid profiles of 113 subjects. Cases (n = 23) were HIV-positive individuals with a stored blood sample available 12 months prior to their diagnosis of coronary artery disease (CAD). They were age and sex matched to HIV-positive individuals without a diagnosis of CAD (n = 45) and with healthy HIV-negative volunteers (n = 45).<h4>Results</h4>Association of plasma lipid species and classes with HIV infection and cardiovascular risk in HIV were determined. In multiple logistic regression, we identified 83 lipids species and 7 lipid classes significantly associated with HIV infection and a further identified 74 lipid species and 8 lipid classes significantly associated with future cardiovascular events in HIV-positive subjects. Risk prediction models incorporating lipid species attained an area under the receiver operator characteristic curve (AUC) of 0.78 (0.775, 0.785)) and outperformed all other tested markers and risk scores in the identification of HIV-positive subjects with increased risk of cardiovascular events.<h4>Conclusions</h4>Our results demonstrate that HIV-positive patients have significant differences in their plasma lipid profiles compared with healthy HIV-negative controls and that numerous lipid species were significantly associated with elevated cardiovascular risk. This suggests a potential novel application for plasma lipids in cardiovascular risk screening of HIV-positive patients.Gerard WongJanine M TrevillyanBenoit FatouMichelle CinelJacquelyn M WeirJennifer F HoyPeter J MeiklePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 4, p e94810 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gerard Wong Janine M Trevillyan Benoit Fatou Michelle Cinel Jacquelyn M Weir Jennifer F Hoy Peter J Meikle Plasma lipidomic profiling of treated HIV-positive individuals and the implications for cardiovascular risk prediction.
description	<h4>Background</h4>The increased risk of coronary artery disease in human immunodeficiency virus (HIV) positive patients is collectively contributed to by the human immunodeficiency virus and antiretroviral-associated dyslipidaemia. In this study, we investigate the characterisation of the plasma lipid profiles of treated HIV patients and the relationship of 316 plasma lipid species across multiple lipid classes with the risk of future cardiovascular events in HIV-positive patients.<h4>Methods</h4>In a retrospective case-control study, we analysed plasma lipid profiles of 113 subjects. Cases (n = 23) were HIV-positive individuals with a stored blood sample available 12 months prior to their diagnosis of coronary artery disease (CAD). They were age and sex matched to HIV-positive individuals without a diagnosis of CAD (n = 45) and with healthy HIV-negative volunteers (n = 45).<h4>Results</h4>Association of plasma lipid species and classes with HIV infection and cardiovascular risk in HIV were determined. In multiple logistic regression, we identified 83 lipids species and 7 lipid classes significantly associated with HIV infection and a further identified 74 lipid species and 8 lipid classes significantly associated with future cardiovascular events in HIV-positive subjects. Risk prediction models incorporating lipid species attained an area under the receiver operator characteristic curve (AUC) of 0.78 (0.775, 0.785)) and outperformed all other tested markers and risk scores in the identification of HIV-positive subjects with increased risk of cardiovascular events.<h4>Conclusions</h4>Our results demonstrate that HIV-positive patients have significant differences in their plasma lipid profiles compared with healthy HIV-negative controls and that numerous lipid species were significantly associated with elevated cardiovascular risk. This suggests a potential novel application for plasma lipids in cardiovascular risk screening of HIV-positive patients.
format	article
author	Gerard Wong Janine M Trevillyan Benoit Fatou Michelle Cinel Jacquelyn M Weir Jennifer F Hoy Peter J Meikle
author_facet	Gerard Wong Janine M Trevillyan Benoit Fatou Michelle Cinel Jacquelyn M Weir Jennifer F Hoy Peter J Meikle
author_sort	Gerard Wong
title	Plasma lipidomic profiling of treated HIV-positive individuals and the implications for cardiovascular risk prediction.
title_short	Plasma lipidomic profiling of treated HIV-positive individuals and the implications for cardiovascular risk prediction.
title_full	Plasma lipidomic profiling of treated HIV-positive individuals and the implications for cardiovascular risk prediction.
title_fullStr	Plasma lipidomic profiling of treated HIV-positive individuals and the implications for cardiovascular risk prediction.
title_full_unstemmed	Plasma lipidomic profiling of treated HIV-positive individuals and the implications for cardiovascular risk prediction.
title_sort	plasma lipidomic profiling of treated hiv-positive individuals and the implications for cardiovascular risk prediction.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/fd8ddb8c6e0d44c9a9055717e391bad9
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Plasma lipidomic profiling of treated HIV-positive individuals and the implications for cardiovascular risk prediction.

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