Multiscale heterogeneity in gastric adenocarcinoma evolution is an obstacle to precision medicine

Abstract Background Cancer is a somatic evolutionary disease and adenocarcinomas of the stomach and gastroesophageal junction (GC) may serve as a two-dimensional model of cancer expansion, in which tumor subclones are not evenly mixed during tumor progression but rather spatially separated and diver...

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Main Authors: Christoph Röcken, Anu Amallraja, Christine Halske, Luka Opasic, Arne Traulsen, Hans-Michael Behrens, Sandra Krüger, Anne Liu, Jochen Haag, Jan-Hendrik Egberts, Philip Rosenstiel, Tobias Meißner
Format: article
Language:EN
Published: BMC 2021
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Online Access:https://doaj.org/article/fd8df01746ac4a9f8e7885c8e7424eff
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