Resting-state functional connectivity changes within the default mode network and the salience network after antipsychotic treatment in early-phase schizophrenia

Yingchan Wang,1 Weijun Tang,2 Xiaoduo Fan,3 Jianye Zhang,1 Daoying Geng,2 Kaida Jiang,1 Dianming Zhu,1 Zhenhua Song,1 Zeping Xiao,1 Dengtang Liu1 1First-Episode Schizophrenia and Early Psychosis Program, Division of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University S...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wang Y, Tang W, Fan X, Zhang J, Geng D, Jiang K, Zhu D, Song Z, Xiao Z, Liu D
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Schizophrenia Resting-state functional connectivity Default mode network Salience network Antipsychotics Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/fd8ee673577f42a1acd45bca2d6bd8c5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fd8ee673577f42a1acd45bca2d6bd8c5
record_format	dspace
spelling	oai:doaj.org-article:fd8ee673577f42a1acd45bca2d6bd8c52021-12-02T07:51:40ZResting-state functional connectivity changes within the default mode network and the salience network after antipsychotic treatment in early-phase schizophrenia1178-2021https://doaj.org/article/fd8ee673577f42a1acd45bca2d6bd8c52017-02-01T00:00:00Zhttps://www.dovepress.com/resting-state-functional-connectivity-changes-within-the-default-mode--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Yingchan Wang,1 Weijun Tang,2 Xiaoduo Fan,3 Jianye Zhang,1 Daoying Geng,2 Kaida Jiang,1 Dianming Zhu,1 Zhenhua Song,1 Zeping Xiao,1 Dengtang Liu1 1First-Episode Schizophrenia and Early Psychosis Program, Division of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 2Department of Radiology, Huashan Hospital, Fu Dan University, Shanghai, People’s Republic of China; 3Psychotic Disorders Program, UMass Memorial Medical Center, UMass Medical School, Worcester, MA, USA Objective: Abnormal resting-state functional connectivity (FC), particularly in the default mode network (DMN) and the salience network (SN), has been reported in schizophrenia, but little is known about the effects of antipsychotics on these networks. The purpose of this study was to examine the effects of atypical antipsychotics on DMN and SN and the relationship between these effects and symptom improvement in patients with schizophrenia.Methods: This was a prospective study of 33 patients diagnosed with schizophrenia and treated with antipsychotics at Shanghai Mental Health Center. Thirty-three healthy controls matched for age and gender were recruited. All subjects underwent functional magnetic resonance imaging (fMRI). Healthy controls were scanned only once; patients were scanned before and after 6–8 weeks of treatment.Results: In the DMN, the patients exhibited increased FC after treatment in the right superior temporal gyrus, right medial frontal gyrus, and left superior frontal gyrus and decreased FC in the right posterior cingulate/precuneus (P<0.005). In the SN, the patients exhibited decreased FC in the right cerebellum anterior lobe and left insula (P<0.005). The FC in the right posterior cingulate/precuneus in the DMN negatively correlated with the difference between the Clinical Global Impression (CGI) score pre/post-treatment (r=–0.564, P=0.023) and negative trends with the difference in the Positive and Negative Syndrome Scale (PANSS) total score pre/post-treatment (r=–0.475, P=0.063) and the difference in PANSS-positive symptom scores (r=–0.481, P=0.060).Conclusion: These findings suggest that atypical antipsychotics could regulate the FC of certain key brain regions within the DMN in early-phase schizophrenia, which might be related to symptom improvement. However, the effects of atypical antipsychotics on SN are less clear. Keywords: schizophrenia, fMRI, default network, salience network, antipsychotics Wang YTang WFan XZhang JGeng DJiang KZhu DSong ZXiao ZLiu DDove Medical PressarticleSchizophreniaResting-state functional connectivityDefault mode networkSalience networkAntipsychoticsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 397-406 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Schizophrenia Resting-state functional connectivity Default mode network Salience network Antipsychotics Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Schizophrenia Resting-state functional connectivity Default mode network Salience network Antipsychotics Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Wang Y Tang W Fan X Zhang J Geng D Jiang K Zhu D Song Z Xiao Z Liu D Resting-state functional connectivity changes within the default mode network and the salience network after antipsychotic treatment in early-phase schizophrenia
description	Yingchan Wang,1 Weijun Tang,2 Xiaoduo Fan,3 Jianye Zhang,1 Daoying Geng,2 Kaida Jiang,1 Dianming Zhu,1 Zhenhua Song,1 Zeping Xiao,1 Dengtang Liu1 1First-Episode Schizophrenia and Early Psychosis Program, Division of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 2Department of Radiology, Huashan Hospital, Fu Dan University, Shanghai, People’s Republic of China; 3Psychotic Disorders Program, UMass Memorial Medical Center, UMass Medical School, Worcester, MA, USA Objective: Abnormal resting-state functional connectivity (FC), particularly in the default mode network (DMN) and the salience network (SN), has been reported in schizophrenia, but little is known about the effects of antipsychotics on these networks. The purpose of this study was to examine the effects of atypical antipsychotics on DMN and SN and the relationship between these effects and symptom improvement in patients with schizophrenia.Methods: This was a prospective study of 33 patients diagnosed with schizophrenia and treated with antipsychotics at Shanghai Mental Health Center. Thirty-three healthy controls matched for age and gender were recruited. All subjects underwent functional magnetic resonance imaging (fMRI). Healthy controls were scanned only once; patients were scanned before and after 6–8 weeks of treatment.Results: In the DMN, the patients exhibited increased FC after treatment in the right superior temporal gyrus, right medial frontal gyrus, and left superior frontal gyrus and decreased FC in the right posterior cingulate/precuneus (P<0.005). In the SN, the patients exhibited decreased FC in the right cerebellum anterior lobe and left insula (P<0.005). The FC in the right posterior cingulate/precuneus in the DMN negatively correlated with the difference between the Clinical Global Impression (CGI) score pre/post-treatment (r=–0.564, P=0.023) and negative trends with the difference in the Positive and Negative Syndrome Scale (PANSS) total score pre/post-treatment (r=–0.475, P=0.063) and the difference in PANSS-positive symptom scores (r=–0.481, P=0.060).Conclusion: These findings suggest that atypical antipsychotics could regulate the FC of certain key brain regions within the DMN in early-phase schizophrenia, which might be related to symptom improvement. However, the effects of atypical antipsychotics on SN are less clear. Keywords: schizophrenia, fMRI, default network, salience network, antipsychotics
format	article
author	Wang Y Tang W Fan X Zhang J Geng D Jiang K Zhu D Song Z Xiao Z Liu D
author_facet	Wang Y Tang W Fan X Zhang J Geng D Jiang K Zhu D Song Z Xiao Z Liu D
author_sort	Wang Y
title	Resting-state functional connectivity changes within the default mode network and the salience network after antipsychotic treatment in early-phase schizophrenia
title_short	Resting-state functional connectivity changes within the default mode network and the salience network after antipsychotic treatment in early-phase schizophrenia
title_full	Resting-state functional connectivity changes within the default mode network and the salience network after antipsychotic treatment in early-phase schizophrenia
title_fullStr	Resting-state functional connectivity changes within the default mode network and the salience network after antipsychotic treatment in early-phase schizophrenia
title_full_unstemmed	Resting-state functional connectivity changes within the default mode network and the salience network after antipsychotic treatment in early-phase schizophrenia
title_sort	resting-state functional connectivity changes within the default mode network and the salience network after antipsychotic treatment in early-phase schizophrenia
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/fd8ee673577f42a1acd45bca2d6bd8c5
work_keys_str_mv	AT wangy restingstatefunctionalconnectivitychangeswithinthedefaultmodenetworkandthesaliencenetworkafterantipsychotictreatmentinearlyphaseschizophrenia AT tangw restingstatefunctionalconnectivitychangeswithinthedefaultmodenetworkandthesaliencenetworkafterantipsychotictreatmentinearlyphaseschizophrenia AT fanx restingstatefunctionalconnectivitychangeswithinthedefaultmodenetworkandthesaliencenetworkafterantipsychotictreatmentinearlyphaseschizophrenia AT zhangj restingstatefunctionalconnectivitychangeswithinthedefaultmodenetworkandthesaliencenetworkafterantipsychotictreatmentinearlyphaseschizophrenia AT gengd restingstatefunctionalconnectivitychangeswithinthedefaultmodenetworkandthesaliencenetworkafterantipsychotictreatmentinearlyphaseschizophrenia AT jiangk restingstatefunctionalconnectivitychangeswithinthedefaultmodenetworkandthesaliencenetworkafterantipsychotictreatmentinearlyphaseschizophrenia AT zhud restingstatefunctionalconnectivitychangeswithinthedefaultmodenetworkandthesaliencenetworkafterantipsychotictreatmentinearlyphaseschizophrenia AT songz restingstatefunctionalconnectivitychangeswithinthedefaultmodenetworkandthesaliencenetworkafterantipsychotictreatmentinearlyphaseschizophrenia AT xiaoz restingstatefunctionalconnectivitychangeswithinthedefaultmodenetworkandthesaliencenetworkafterantipsychotictreatmentinearlyphaseschizophrenia AT liud restingstatefunctionalconnectivitychangeswithinthedefaultmodenetworkandthesaliencenetworkafterantipsychotictreatmentinearlyphaseschizophrenia
_version_	1718399197594517504

Resting-state functional connectivity changes within the default mode network and the salience network after antipsychotic treatment in early-phase schizophrenia

Ejemplares similares