Diabetes disease progression in Goto-Kakizaki rats: effects of salsalate treatment

Xi Wang,1 Debra C DuBois,1,2 Yanguang Cao,2 William J Jusko,2,3 Richard R Almon1–31Department of Biological Sciences, University at Buffalo, Buffalo, NY, USA; 2Department of Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, USA; 3New York State Center of Excellence in Bioinform...

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Autores principales:	Wang X, DuBois DC, Cao Y, Jusko WJ, Almon RR
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/fd903f42f92a4e29a58bfcda24146945
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spelling	oai:doaj.org-article:fd903f42f92a4e29a58bfcda241469452021-12-02T07:10:57ZDiabetes disease progression in Goto-Kakizaki rats: effects of salsalate treatment1178-7007https://doaj.org/article/fd903f42f92a4e29a58bfcda241469452014-08-01T00:00:00Zhttp://www.dovepress.com/diabetes-disease-progression-in-goto-kakizaki-rats-effects-of-salsalat-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007 Xi Wang,1 Debra C DuBois,1,2 Yanguang Cao,2 William J Jusko,2,3 Richard R Almon1–31Department of Biological Sciences, University at Buffalo, Buffalo, NY, USA; 2Department of Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, USA; 3New York State Center of Excellence in Bioinformatics and Life Sciences, Buffalo, NY, USAAbstract: This study investigates the antidiabetic effects of salsalate on disease progression of diabetes in non-obese diabetic Goto-Kakizaki (GK) rats, an experimental model of type 2 diabetes. Salsalate was formulated in rat chow (1,000 ppm) and used to feed rats from 5 to 21 weeks of age. At 5 weeks of age, GK and Wistar (WIS) control rats were subdivided into four groups, each composed of six rats: GK rats with standard diet (GK-C); GK rats with salsalate-containing diet (GK-S); WIS rats with standard diet (WIS-C); and WIS rats with salsalate-containing diet (WIS-S). The GK-C rats (167.2±11.6 mg/dL) showed higher blood glucose concentrations than WIS-C rats (133.7±4.9 mg/dL, P<0.001) at the beginning of the experiment, and had substantially elevated blood glucose from an age of 15 weeks until sacrifice at 21 weeks (341.0±133.6 mg/dL). The GK-S rats showed an almost flat profile of blood glucose from 4 weeks (165.1±11.0 mg/dL) until sacrifice at 21 weeks of age (203.7±22.2 mg/dL). While this difference in blood glucose between 4 and 21 weeks in GK-S animals was significant, blood glucose at 21 weeks was significantly lower in GK-S compared to GK-C animals. At sacrifice, salsalate decreased plasma insulin (GK-S =1.0±0.3; GK-C =2.0±0.3 ng/mL, P<0.001) and increased plasma adiponectin concentrations (GK-S =15.9±0.7; GK-C =9.7±2.0 µg/mL, P<0.001). Salsalate also lowered total cholesterol in GK-S rats (96.1±8.5 mg/dL) compared with GK-C rats (128.0±11.4 mg/dL, P<0.001). Inflammation-related genes (Ifit1 and Iigp1) exhibited much higher mRNA expression in GK-C rats than WIS-C rats in liver, adipose, and muscle tissues, while salsalate decreased the Ifit1 and Iigp1 mRNA only in adipose tissue. These results suggest that salsalate acts to both increase adiponectin and decrease adipose tissue-based inflammation while preventing type 2 diabetes disease progression in GK rats.Keywords: type 2 diabetes, salicylates, inflammation, adiponectinWang XDuBois DCCao YJusko WJAlmon RRDove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2014, Iss default, Pp 381-389 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Specialties of internal medicine RC581-951
spellingShingle	Specialties of internal medicine RC581-951 Wang X DuBois DC Cao Y Jusko WJ Almon RR Diabetes disease progression in Goto-Kakizaki rats: effects of salsalate treatment
description	Xi Wang,1 Debra C DuBois,1,2 Yanguang Cao,2 William J Jusko,2,3 Richard R Almon1–31Department of Biological Sciences, University at Buffalo, Buffalo, NY, USA; 2Department of Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, USA; 3New York State Center of Excellence in Bioinformatics and Life Sciences, Buffalo, NY, USAAbstract: This study investigates the antidiabetic effects of salsalate on disease progression of diabetes in non-obese diabetic Goto-Kakizaki (GK) rats, an experimental model of type 2 diabetes. Salsalate was formulated in rat chow (1,000 ppm) and used to feed rats from 5 to 21 weeks of age. At 5 weeks of age, GK and Wistar (WIS) control rats were subdivided into four groups, each composed of six rats: GK rats with standard diet (GK-C); GK rats with salsalate-containing diet (GK-S); WIS rats with standard diet (WIS-C); and WIS rats with salsalate-containing diet (WIS-S). The GK-C rats (167.2±11.6 mg/dL) showed higher blood glucose concentrations than WIS-C rats (133.7±4.9 mg/dL, P<0.001) at the beginning of the experiment, and had substantially elevated blood glucose from an age of 15 weeks until sacrifice at 21 weeks (341.0±133.6 mg/dL). The GK-S rats showed an almost flat profile of blood glucose from 4 weeks (165.1±11.0 mg/dL) until sacrifice at 21 weeks of age (203.7±22.2 mg/dL). While this difference in blood glucose between 4 and 21 weeks in GK-S animals was significant, blood glucose at 21 weeks was significantly lower in GK-S compared to GK-C animals. At sacrifice, salsalate decreased plasma insulin (GK-S =1.0±0.3; GK-C =2.0±0.3 ng/mL, P<0.001) and increased plasma adiponectin concentrations (GK-S =15.9±0.7; GK-C =9.7±2.0 µg/mL, P<0.001). Salsalate also lowered total cholesterol in GK-S rats (96.1±8.5 mg/dL) compared with GK-C rats (128.0±11.4 mg/dL, P<0.001). Inflammation-related genes (Ifit1 and Iigp1) exhibited much higher mRNA expression in GK-C rats than WIS-C rats in liver, adipose, and muscle tissues, while salsalate decreased the Ifit1 and Iigp1 mRNA only in adipose tissue. These results suggest that salsalate acts to both increase adiponectin and decrease adipose tissue-based inflammation while preventing type 2 diabetes disease progression in GK rats.Keywords: type 2 diabetes, salicylates, inflammation, adiponectin
format	article
author	Wang X DuBois DC Cao Y Jusko WJ Almon RR
author_facet	Wang X DuBois DC Cao Y Jusko WJ Almon RR
author_sort	Wang X
title	Diabetes disease progression in Goto-Kakizaki rats: effects of salsalate treatment
title_short	Diabetes disease progression in Goto-Kakizaki rats: effects of salsalate treatment
title_full	Diabetes disease progression in Goto-Kakizaki rats: effects of salsalate treatment
title_fullStr	Diabetes disease progression in Goto-Kakizaki rats: effects of salsalate treatment
title_full_unstemmed	Diabetes disease progression in Goto-Kakizaki rats: effects of salsalate treatment
title_sort	diabetes disease progression in goto-kakizaki rats: effects of salsalate treatment
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/fd903f42f92a4e29a58bfcda24146945
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Diabetes disease progression in Goto-Kakizaki rats: effects of salsalate treatment

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