The role of polygenic risk and susceptibility genes in breast cancer over the course of life

Identifying women at high risk of breast cancer has important implications for screening. Here, the authors demonstrate that polygenic risk scores improve breast cancer risk prediction in the population, in women with mutations in high-risk genes and in women with close relatives with the disease.

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Autores principales:	Nina Mars, Elisabeth Widén, Sini Kerminen, Tuomo Meretoja, Matti Pirinen, Pietro della Briotta Parolo, Priit Palta, FinnGen, Aarno Palotie, Jaakko Kaprio, Heikki Joensuu, Mark Daly, Samuli Ripatti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fd90f82ba68946fbb3ef19bfa8e2fc82
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spelling	oai:doaj.org-article:fd90f82ba68946fbb3ef19bfa8e2fc822021-12-02T13:57:55ZThe role of polygenic risk and susceptibility genes in breast cancer over the course of life10.1038/s41467-020-19966-52041-1723https://doaj.org/article/fd90f82ba68946fbb3ef19bfa8e2fc822020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19966-5https://doaj.org/toc/2041-1723Identifying women at high risk of breast cancer has important implications for screening. Here, the authors demonstrate that polygenic risk scores improve breast cancer risk prediction in the population, in women with mutations in high-risk genes and in women with close relatives with the disease.Nina MarsElisabeth WidénSini KerminenTuomo MeretojaMatti PirinenPietro della Briotta ParoloPriit PaltaFinnGenAarno PalotieJaakko KaprioHeikki JoensuuMark DalySamuli RipattiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nina Mars Elisabeth Widén Sini Kerminen Tuomo Meretoja Matti Pirinen Pietro della Briotta Parolo Priit Palta FinnGen Aarno Palotie Jaakko Kaprio Heikki Joensuu Mark Daly Samuli Ripatti The role of polygenic risk and susceptibility genes in breast cancer over the course of life
description	Identifying women at high risk of breast cancer has important implications for screening. Here, the authors demonstrate that polygenic risk scores improve breast cancer risk prediction in the population, in women with mutations in high-risk genes and in women with close relatives with the disease.
format	article
author	Nina Mars Elisabeth Widén Sini Kerminen Tuomo Meretoja Matti Pirinen Pietro della Briotta Parolo Priit Palta FinnGen Aarno Palotie Jaakko Kaprio Heikki Joensuu Mark Daly Samuli Ripatti
author_facet	Nina Mars Elisabeth Widén Sini Kerminen Tuomo Meretoja Matti Pirinen Pietro della Briotta Parolo Priit Palta FinnGen Aarno Palotie Jaakko Kaprio Heikki Joensuu Mark Daly Samuli Ripatti
author_sort	Nina Mars
title	The role of polygenic risk and susceptibility genes in breast cancer over the course of life
title_short	The role of polygenic risk and susceptibility genes in breast cancer over the course of life
title_full	The role of polygenic risk and susceptibility genes in breast cancer over the course of life
title_fullStr	The role of polygenic risk and susceptibility genes in breast cancer over the course of life
title_full_unstemmed	The role of polygenic risk and susceptibility genes in breast cancer over the course of life
title_sort	role of polygenic risk and susceptibility genes in breast cancer over the course of life
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/fd90f82ba68946fbb3ef19bfa8e2fc82
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The role of polygenic risk and susceptibility genes in breast cancer over the course of life

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