Lens densitometry for assessment and prediction of cataract progression after pars plana vitrectomy with C3F8-gas for retinal detachment.

<h4>Purpose</h4>Lens opacification is a common complication after pars plana vitrectomy (PPV) and knowing its progression would facilitate consulting patients. The purpose of this study was to evaluate a quantitative model for lens-status-monitoring after PPV with C3F8 gas. Our model was...

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Autores principales:	Philipp Schindler, Luca Mautone, Eileen Bigdon, Vasyl Druchkiv, Martin Stefan Spitzer, Christos Skevas
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fd919faf6c20416b9d189804eda5d901
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spelling	oai:doaj.org-article:fd919faf6c20416b9d189804eda5d9012021-12-02T20:09:17ZLens densitometry for assessment and prediction of cataract progression after pars plana vitrectomy with C3F8-gas for retinal detachment.1932-620310.1371/journal.pone.0254370https://doaj.org/article/fd919faf6c20416b9d189804eda5d9012021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254370https://doaj.org/toc/1932-6203<h4>Purpose</h4>Lens opacification is a common complication after pars plana vitrectomy (PPV) and knowing its progression would facilitate consulting patients. The purpose of this study was to evaluate a quantitative model for lens-status-monitoring after PPV with C3F8 gas. Our model was evaluated in rhegmatogenous retinal detachment (RRD) patients of various age and lens densitometry (LD).<h4>Methods</h4>Data between March 2018 and March 2020 were evaluated retrospectively. LD measurements of the PentacamHR® Nucleus Staging mode (PNS) were used to quantify lens opacification over time. A mixed-effect regression model was designed, to enable LD predictions at any time postoperatively. Calculations were based on patient's age and baseline LD as dependent variables. Six patients were randomly excluded during model development, to be used for testing its power afterwards.<h4>Results</h4>34 patients (male 19 [55.9%], female 15 [44.1%]) matched the inclusion criteria. Average age was 58.5 years (32-77;±4.3) and average follow-up was 7.2 months (3,4-23.1;±1,8). Mean baseline LD of the treated and fellow eye before surgery were 10.9% (8.7%-14.8%;±0.8) and 10.7% (8.5%-14.1%;±0.6), respectively. Using our prediction model, LD values for the six pre-selected patients closely match the observed data with an average deviation of 1.07%.<h4>Conclusions</h4>Evaluation of age and baseline LD using a mixed-effect regression model might predict cataract progression in RRD patients treated with PPV and C3F8-gas. Such a tool could be considered during cataract surgery consultation in these patients.Philipp SchindlerLuca MautoneEileen BigdonVasyl DruchkivMartin Stefan SpitzerChristos SkevasPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254370 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Philipp Schindler Luca Mautone Eileen Bigdon Vasyl Druchkiv Martin Stefan Spitzer Christos Skevas Lens densitometry for assessment and prediction of cataract progression after pars plana vitrectomy with C3F8-gas for retinal detachment.
description	<h4>Purpose</h4>Lens opacification is a common complication after pars plana vitrectomy (PPV) and knowing its progression would facilitate consulting patients. The purpose of this study was to evaluate a quantitative model for lens-status-monitoring after PPV with C3F8 gas. Our model was evaluated in rhegmatogenous retinal detachment (RRD) patients of various age and lens densitometry (LD).<h4>Methods</h4>Data between March 2018 and March 2020 were evaluated retrospectively. LD measurements of the PentacamHR® Nucleus Staging mode (PNS) were used to quantify lens opacification over time. A mixed-effect regression model was designed, to enable LD predictions at any time postoperatively. Calculations were based on patient's age and baseline LD as dependent variables. Six patients were randomly excluded during model development, to be used for testing its power afterwards.<h4>Results</h4>34 patients (male 19 [55.9%], female 15 [44.1%]) matched the inclusion criteria. Average age was 58.5 years (32-77;±4.3) and average follow-up was 7.2 months (3,4-23.1;±1,8). Mean baseline LD of the treated and fellow eye before surgery were 10.9% (8.7%-14.8%;±0.8) and 10.7% (8.5%-14.1%;±0.6), respectively. Using our prediction model, LD values for the six pre-selected patients closely match the observed data with an average deviation of 1.07%.<h4>Conclusions</h4>Evaluation of age and baseline LD using a mixed-effect regression model might predict cataract progression in RRD patients treated with PPV and C3F8-gas. Such a tool could be considered during cataract surgery consultation in these patients.
format	article
author	Philipp Schindler Luca Mautone Eileen Bigdon Vasyl Druchkiv Martin Stefan Spitzer Christos Skevas
author_facet	Philipp Schindler Luca Mautone Eileen Bigdon Vasyl Druchkiv Martin Stefan Spitzer Christos Skevas
author_sort	Philipp Schindler
title	Lens densitometry for assessment and prediction of cataract progression after pars plana vitrectomy with C3F8-gas for retinal detachment.
title_short	Lens densitometry for assessment and prediction of cataract progression after pars plana vitrectomy with C3F8-gas for retinal detachment.
title_full	Lens densitometry for assessment and prediction of cataract progression after pars plana vitrectomy with C3F8-gas for retinal detachment.
title_fullStr	Lens densitometry for assessment and prediction of cataract progression after pars plana vitrectomy with C3F8-gas for retinal detachment.
title_full_unstemmed	Lens densitometry for assessment and prediction of cataract progression after pars plana vitrectomy with C3F8-gas for retinal detachment.
title_sort	lens densitometry for assessment and prediction of cataract progression after pars plana vitrectomy with c3f8-gas for retinal detachment.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/fd919faf6c20416b9d189804eda5d901
work_keys_str_mv	AT philippschindler lensdensitometryforassessmentandpredictionofcataractprogressionafterparsplanavitrectomywithc3f8gasforretinaldetachment AT lucamautone lensdensitometryforassessmentandpredictionofcataractprogressionafterparsplanavitrectomywithc3f8gasforretinaldetachment AT eileenbigdon lensdensitometryforassessmentandpredictionofcataractprogressionafterparsplanavitrectomywithc3f8gasforretinaldetachment AT vasyldruchkiv lensdensitometryforassessmentandpredictionofcataractprogressionafterparsplanavitrectomywithc3f8gasforretinaldetachment AT martinstefanspitzer lensdensitometryforassessmentandpredictionofcataractprogressionafterparsplanavitrectomywithc3f8gasforretinaldetachment AT christosskevas lensdensitometryforassessmentandpredictionofcataractprogressionafterparsplanavitrectomywithc3f8gasforretinaldetachment
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Lens densitometry for assessment and prediction of cataract progression after pars plana vitrectomy with C3F8-gas for retinal detachment.

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