Effect of Kidney Dysfunction on Cerebral Cortical Thinning in Elderly Population
Abstract Chronic kidney disease has been linked to cognitive impairment and morphological brain change. However, less is known about the impact of kidney functions on cerebral cortical thickness. This study investigated the relationship between kidney functions and global or lobar cerebral cortical...
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Nature Portfolio
2017
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oai:doaj.org-article:fd91c308b8734aff92e7ec65bb00dc722021-12-02T11:52:58ZEffect of Kidney Dysfunction on Cerebral Cortical Thinning in Elderly Population10.1038/s41598-017-02537-y2045-2322https://doaj.org/article/fd91c308b8734aff92e7ec65bb00dc722017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02537-yhttps://doaj.org/toc/2045-2322Abstract Chronic kidney disease has been linked to cognitive impairment and morphological brain change. However, less is known about the impact of kidney functions on cerebral cortical thickness. This study investigated the relationship between kidney functions and global or lobar cerebral cortical thickness (CTh) in 259 non-demented elderly persons. Forty-three participants (16.7%) had kidney dysfunction, which was defined as either a glomerular filtration rate (GFR) of <60 ml/min/1.73 m2 or presence of proteinuria. Kidney dysfunction was associated with lower global (β = −0.05, 95% CI = −0.08 to −0.01) as well as frontal, parietal, temporal, occipital, and insular lobar CTh. In the stratified analysis, the associations were more pronounced in women, APOEε4 non-carriers, and participants with a lower cognitive score. Besides, kidney dysfunction significantly increased the risk of cortical thinning, defined as being the lowest CTh tertile, in the insular lobe (adjusted odds ratio = 2.74, 95% CI = 1.31−5.74). Our results suggested that kidney dysfunction should be closely monitored and managed in elderly population to prevent neurodegeneration.Chih-Hao ChenYa-Fang ChenMing-Jang ChiuTa-Fu ChenPing-Huan TsaiJen-Hau ChenChung-Jen YenSung-Chun TangShin-Joe YehYen-Ching ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017) |
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Medicine R Science Q |
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Medicine R Science Q Chih-Hao Chen Ya-Fang Chen Ming-Jang Chiu Ta-Fu Chen Ping-Huan Tsai Jen-Hau Chen Chung-Jen Yen Sung-Chun Tang Shin-Joe Yeh Yen-Ching Chen Effect of Kidney Dysfunction on Cerebral Cortical Thinning in Elderly Population |
| description |
Abstract Chronic kidney disease has been linked to cognitive impairment and morphological brain change. However, less is known about the impact of kidney functions on cerebral cortical thickness. This study investigated the relationship between kidney functions and global or lobar cerebral cortical thickness (CTh) in 259 non-demented elderly persons. Forty-three participants (16.7%) had kidney dysfunction, which was defined as either a glomerular filtration rate (GFR) of <60 ml/min/1.73 m2 or presence of proteinuria. Kidney dysfunction was associated with lower global (β = −0.05, 95% CI = −0.08 to −0.01) as well as frontal, parietal, temporal, occipital, and insular lobar CTh. In the stratified analysis, the associations were more pronounced in women, APOEε4 non-carriers, and participants with a lower cognitive score. Besides, kidney dysfunction significantly increased the risk of cortical thinning, defined as being the lowest CTh tertile, in the insular lobe (adjusted odds ratio = 2.74, 95% CI = 1.31−5.74). Our results suggested that kidney dysfunction should be closely monitored and managed in elderly population to prevent neurodegeneration. |
| format |
article |
| author |
Chih-Hao Chen Ya-Fang Chen Ming-Jang Chiu Ta-Fu Chen Ping-Huan Tsai Jen-Hau Chen Chung-Jen Yen Sung-Chun Tang Shin-Joe Yeh Yen-Ching Chen |
| author_facet |
Chih-Hao Chen Ya-Fang Chen Ming-Jang Chiu Ta-Fu Chen Ping-Huan Tsai Jen-Hau Chen Chung-Jen Yen Sung-Chun Tang Shin-Joe Yeh Yen-Ching Chen |
| author_sort |
Chih-Hao Chen |
| title |
Effect of Kidney Dysfunction on Cerebral Cortical Thinning in Elderly Population |
| title_short |
Effect of Kidney Dysfunction on Cerebral Cortical Thinning in Elderly Population |
| title_full |
Effect of Kidney Dysfunction on Cerebral Cortical Thinning in Elderly Population |
| title_fullStr |
Effect of Kidney Dysfunction on Cerebral Cortical Thinning in Elderly Population |
| title_full_unstemmed |
Effect of Kidney Dysfunction on Cerebral Cortical Thinning in Elderly Population |
| title_sort |
effect of kidney dysfunction on cerebral cortical thinning in elderly population |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/fd91c308b8734aff92e7ec65bb00dc72 |
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