Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors

Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors

Pancreatic progenitors (PPs) can be derived from human pluripotent stem cells in vitro but efficiency of differentiation varies, making it hard to sort for insulin-producing cells. Here, the authors use a proteomic approach to identify the secretory granule membrane glycoprotein 2 as a marker for PD...

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Autores principales: Kathryn F. Cogger, Ankit Sinha, Farida Sarangi, Emily C. McGaugh, Diane Saunders, Craig Dorrell, Salvador Mejia-Guerrero, Yasaman Aghazadeh, Jillian L. Rourke, Robert A. Screaton, Markus Grompe, Philip R. Streeter, Alvin C. Powers, Marcela Brissova, Thomas Kislinger, M. Cristina Nostro
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/fd9272cedfac4963a9e8b1e7fd7c10ad
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Sumario:Pancreatic progenitors (PPs) can be derived from human pluripotent stem cells in vitro but efficiency of differentiation varies, making it hard to sort for insulin-producing cells. Here, the authors use a proteomic approach to identify the secretory granule membrane glycoprotein 2 as a marker for PDX1+/NKX6-1+ PPs.

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