Platelet-Mimicking Drug Delivery Nanoparticles for Enhanced Chemo-Photothermal Therapy of Breast Cancer

Wenjing Pei,1,2 Biying Huang,1,2 Sijie Chen,1,2 Long Wang,3 Yan Xu,1,2 Chengcheng Niu1,2 1Department of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, People’s Republic of China; 2Research Center of Ultrasonography, The Second Xiangya H...

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Autores principales:	Pei W, Huang B, Chen S, Wang L, Xu Y, Niu C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	platelet-mimicking drug delivery ir780 doxorubicin chemo-photothermal therapy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/fd93ed09a6724d24939e928cf0aab35b
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spelling	oai:doaj.org-article:fd93ed09a6724d24939e928cf0aab35b2021-12-02T13:47:45ZPlatelet-Mimicking Drug Delivery Nanoparticles for Enhanced Chemo-Photothermal Therapy of Breast Cancer1178-2013https://doaj.org/article/fd93ed09a6724d24939e928cf0aab35b2020-12-01T00:00:00Zhttps://www.dovepress.com/platelet-mimicking-drug-delivery-nanoparticles-for-enhanced-chemo-phot-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Wenjing Pei,1,2 Biying Huang,1,2 Sijie Chen,1,2 Long Wang,3 Yan Xu,1,2 Chengcheng Niu1,2 1Department of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, People’s Republic of China; 2Research Center of Ultrasonography, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, People’s Republic of China; 3Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, People’s Republic of ChinaCorrespondence: Chengcheng NiuDepartment of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, People’s Republic of ChinaEmail niuchengcheng@csu.edu.cnBackground: Traditional nanoparticle-based drug delivery systems suffer from several limitations, such as easy clearance from blood and inaccurate targeting.Materials and Methods: Here, we developed platelet membrane-coated nanoparticles (PM-NPs) to improve the precise delivery of drugs to tumor sites and enable a more efficient photothermal therapy (PTT) treatment.Results: Mimicking the natural platelet membrane, nanoparticles containing drugs and photothermal agents were not recognized and cleared by the immune system; they could circulate in the blood for a long time and accumulate more efficiently at the tumor site, thus releasing more antitumor drugs and achieving better PTT effects. It is worth mentioning that, in this study, we found that tumors in mice treated with the platelet-mimicking nanoparticles were completely eliminated without recurrence during the observation period (up to 18 days).Conclusion: This study provides a new strategy to design delivery systems of drugs or photothermal agents, whether in biotherapy or other fields.Keywords: platelet-mimicking, drug delivery, IR780, doxorubicin, chemo-photothermal therapyPei WHuang BChen SWang LXu YNiu CDove Medical Pressarticleplatelet-mimickingdrug deliveryir780doxorubicinchemo-photothermal therapyMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 10151-10167 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	platelet-mimicking drug delivery ir780 doxorubicin chemo-photothermal therapy Medicine (General) R5-920
spellingShingle	platelet-mimicking drug delivery ir780 doxorubicin chemo-photothermal therapy Medicine (General) R5-920 Pei W Huang B Chen S Wang L Xu Y Niu C Platelet-Mimicking Drug Delivery Nanoparticles for Enhanced Chemo-Photothermal Therapy of Breast Cancer
description	Wenjing Pei,1,2 Biying Huang,1,2 Sijie Chen,1,2 Long Wang,3 Yan Xu,1,2 Chengcheng Niu1,2 1Department of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, People’s Republic of China; 2Research Center of Ultrasonography, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, People’s Republic of China; 3Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, People’s Republic of ChinaCorrespondence: Chengcheng NiuDepartment of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, People’s Republic of ChinaEmail niuchengcheng@csu.edu.cnBackground: Traditional nanoparticle-based drug delivery systems suffer from several limitations, such as easy clearance from blood and inaccurate targeting.Materials and Methods: Here, we developed platelet membrane-coated nanoparticles (PM-NPs) to improve the precise delivery of drugs to tumor sites and enable a more efficient photothermal therapy (PTT) treatment.Results: Mimicking the natural platelet membrane, nanoparticles containing drugs and photothermal agents were not recognized and cleared by the immune system; they could circulate in the blood for a long time and accumulate more efficiently at the tumor site, thus releasing more antitumor drugs and achieving better PTT effects. It is worth mentioning that, in this study, we found that tumors in mice treated with the platelet-mimicking nanoparticles were completely eliminated without recurrence during the observation period (up to 18 days).Conclusion: This study provides a new strategy to design delivery systems of drugs or photothermal agents, whether in biotherapy or other fields.Keywords: platelet-mimicking, drug delivery, IR780, doxorubicin, chemo-photothermal therapy
format	article
author	Pei W Huang B Chen S Wang L Xu Y Niu C
author_facet	Pei W Huang B Chen S Wang L Xu Y Niu C
author_sort	Pei W
title	Platelet-Mimicking Drug Delivery Nanoparticles for Enhanced Chemo-Photothermal Therapy of Breast Cancer
title_short	Platelet-Mimicking Drug Delivery Nanoparticles for Enhanced Chemo-Photothermal Therapy of Breast Cancer
title_full	Platelet-Mimicking Drug Delivery Nanoparticles for Enhanced Chemo-Photothermal Therapy of Breast Cancer
title_fullStr	Platelet-Mimicking Drug Delivery Nanoparticles for Enhanced Chemo-Photothermal Therapy of Breast Cancer
title_full_unstemmed	Platelet-Mimicking Drug Delivery Nanoparticles for Enhanced Chemo-Photothermal Therapy of Breast Cancer
title_sort	platelet-mimicking drug delivery nanoparticles for enhanced chemo-photothermal therapy of breast cancer
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/fd93ed09a6724d24939e928cf0aab35b
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Platelet-Mimicking Drug Delivery Nanoparticles for Enhanced Chemo-Photothermal Therapy of Breast Cancer

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