Olfactory function in the trace amine-associated receptor family (TAARs) evolved twice independently

Abstract Olfactory receptor families have arisen independently several times during evolution. The origin of taar genes, one of the four major vertebrate olfactory receptor families, is disputed. We performed a phylogenetic analysis making use of 96 recently available genomes, and report that olfact...

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Autores principales:	Milan Dieris, Daniel Kowatschew, Sigrun I. Korsching
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fd96c366ef3045d280494802f9b36dd0
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spelling	oai:doaj.org-article:fd96c366ef3045d280494802f9b36dd02021-12-02T14:17:27ZOlfactory function in the trace amine-associated receptor family (TAARs) evolved twice independently10.1038/s41598-021-87236-52045-2322https://doaj.org/article/fd96c366ef3045d280494802f9b36dd02021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87236-5https://doaj.org/toc/2045-2322Abstract Olfactory receptor families have arisen independently several times during evolution. The origin of taar genes, one of the four major vertebrate olfactory receptor families, is disputed. We performed a phylogenetic analysis making use of 96 recently available genomes, and report that olfactory functionality has arisen twice independently within the TAAR family, once in jawed and once in jawless fish. In lamprey, an ancestral gene expanded to generate a large family of olfactory receptors, while the sister gene in jawed vertebrates did not expand and is not expressed in olfactory sensory neurons. Both clades do not exhibit the defining TAAR motif, and we suggest naming them taar-like receptors (tarl). We have identified the evolutionary origin of both taar and tarl genes in a duplication of the serotonergic receptor 4 that occurred in the most recent common ancestor of vertebrates. We infer two ancestral genes in bony fish (TAAR12, TAAR13) which gave rise to the complete repertoire of mammalian olfactory taar genes and to class II of the taar repertoire of teleost fish. We follow their evolution in seventy-one bony fish genomes and report a high evolutionary dynamic, with many late gene birth events and both early and late gene death events.Milan DierisDaniel KowatschewSigrun I. KorschingNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Milan Dieris Daniel Kowatschew Sigrun I. Korsching Olfactory function in the trace amine-associated receptor family (TAARs) evolved twice independently
description	Abstract Olfactory receptor families have arisen independently several times during evolution. The origin of taar genes, one of the four major vertebrate olfactory receptor families, is disputed. We performed a phylogenetic analysis making use of 96 recently available genomes, and report that olfactory functionality has arisen twice independently within the TAAR family, once in jawed and once in jawless fish. In lamprey, an ancestral gene expanded to generate a large family of olfactory receptors, while the sister gene in jawed vertebrates did not expand and is not expressed in olfactory sensory neurons. Both clades do not exhibit the defining TAAR motif, and we suggest naming them taar-like receptors (tarl). We have identified the evolutionary origin of both taar and tarl genes in a duplication of the serotonergic receptor 4 that occurred in the most recent common ancestor of vertebrates. We infer two ancestral genes in bony fish (TAAR12, TAAR13) which gave rise to the complete repertoire of mammalian olfactory taar genes and to class II of the taar repertoire of teleost fish. We follow their evolution in seventy-one bony fish genomes and report a high evolutionary dynamic, with many late gene birth events and both early and late gene death events.
format	article
author	Milan Dieris Daniel Kowatschew Sigrun I. Korsching
author_facet	Milan Dieris Daniel Kowatschew Sigrun I. Korsching
author_sort	Milan Dieris
title	Olfactory function in the trace amine-associated receptor family (TAARs) evolved twice independently
title_short	Olfactory function in the trace amine-associated receptor family (TAARs) evolved twice independently
title_full	Olfactory function in the trace amine-associated receptor family (TAARs) evolved twice independently
title_fullStr	Olfactory function in the trace amine-associated receptor family (TAARs) evolved twice independently
title_full_unstemmed	Olfactory function in the trace amine-associated receptor family (TAARs) evolved twice independently
title_sort	olfactory function in the trace amine-associated receptor family (taars) evolved twice independently
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fd96c366ef3045d280494802f9b36dd0
work_keys_str_mv	AT milandieris olfactoryfunctioninthetraceamineassociatedreceptorfamilytaarsevolvedtwiceindependently AT danielkowatschew olfactoryfunctioninthetraceamineassociatedreceptorfamilytaarsevolvedtwiceindependently AT sigrunikorsching olfactoryfunctioninthetraceamineassociatedreceptorfamilytaarsevolvedtwiceindependently
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Olfactory function in the trace amine-associated receptor family (TAARs) evolved twice independently

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