The reliability and validity of DSM 5 diagnostic criteria for neurocognitive disorder and relationship with plasma neurofilament light in a down syndrome population

Abstract The validity of dementia diagnostic criteria depends on their ability to distinguish dementia symptoms from pre-existing cognitive impairments. The study aimed to assess inter-rater reliability and concurrent validity of DSM-5 criteria for neurocognitive disorder in Down syndrome. The utili...

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Autores principales:	Sarah E. Pape, Tamara al Janabi, Nicholas J. Ashton, Abdul Hye, Rory Sheehan, Paul Gallagher, Bernice Knight, Anne-Marije Prins, Ken Courtenay, Vesna Jordanova, Bini Thomas, Nagarajan Perumal, Craig Forbes, Angela Hassiotis, Andre Strydom
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fd96eaea78ba49ceb19d5f682329bcbe
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spelling	oai:doaj.org-article:fd96eaea78ba49ceb19d5f682329bcbe2021-12-02T16:10:36ZThe reliability and validity of DSM 5 diagnostic criteria for neurocognitive disorder and relationship with plasma neurofilament light in a down syndrome population10.1038/s41598-021-92887-52045-2322https://doaj.org/article/fd96eaea78ba49ceb19d5f682329bcbe2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92887-5https://doaj.org/toc/2045-2322Abstract The validity of dementia diagnostic criteria depends on their ability to distinguish dementia symptoms from pre-existing cognitive impairments. The study aimed to assess inter-rater reliability and concurrent validity of DSM-5 criteria for neurocognitive disorder in Down syndrome. The utility of mild neurocognitive disorder as a distinct diagnostic category, and the association between clinical symptoms and neurodegenerative changes represented by the plasma biomarker neurofilament light were also examined. 165 adults with Down syndrome were included. Two clinicians independently applied clinical judgement, DSM-IV, ICD-10 and DSM-5 criteria for dementia (or neurocognitive disorder) to each case. Inter-rater reliability and concurrent validity were analysed using the kappa statistic. Plasma neurofilament light concentrations were measured for 55 participants as a marker of neurodegeneration and between group comparisons calculated. All diagnostic criteria showed good inter-rater reliability apart from mild neurocognitive disorder which was moderate (k = 0.494). DSM- 5 criteria had substantial concurrence with clinical judgement (k = 0.855). When compared to the no neurocognitive disorder group, average neurofilament light concentrations were higher in both the mild and major neurocognitive disorder groups. DSM-5 neurocognitive disorder criteria can be used reliably in a Down syndrome population and has higher concurrence with clinical judgement than the older DSM-IV and ICD-10 criteria. Whilst the inter-rater reliability of the mild neurocognitive disorder criteria was modest, it does appear to identify people in an early stage of dementia with underlying neurodegenerative changes, represented by higher average NfL levels.Sarah E. PapeTamara al JanabiNicholas J. AshtonAbdul HyeRory SheehanPaul GallagherBernice KnightAnne-Marije PrinsKen CourtenayVesna JordanovaBini ThomasNagarajan PerumalCraig ForbesAngela HassiotisAndre StrydomNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sarah E. Pape Tamara al Janabi Nicholas J. Ashton Abdul Hye Rory Sheehan Paul Gallagher Bernice Knight Anne-Marije Prins Ken Courtenay Vesna Jordanova Bini Thomas Nagarajan Perumal Craig Forbes Angela Hassiotis Andre Strydom The reliability and validity of DSM 5 diagnostic criteria for neurocognitive disorder and relationship with plasma neurofilament light in a down syndrome population
description	Abstract The validity of dementia diagnostic criteria depends on their ability to distinguish dementia symptoms from pre-existing cognitive impairments. The study aimed to assess inter-rater reliability and concurrent validity of DSM-5 criteria for neurocognitive disorder in Down syndrome. The utility of mild neurocognitive disorder as a distinct diagnostic category, and the association between clinical symptoms and neurodegenerative changes represented by the plasma biomarker neurofilament light were also examined. 165 adults with Down syndrome were included. Two clinicians independently applied clinical judgement, DSM-IV, ICD-10 and DSM-5 criteria for dementia (or neurocognitive disorder) to each case. Inter-rater reliability and concurrent validity were analysed using the kappa statistic. Plasma neurofilament light concentrations were measured for 55 participants as a marker of neurodegeneration and between group comparisons calculated. All diagnostic criteria showed good inter-rater reliability apart from mild neurocognitive disorder which was moderate (k = 0.494). DSM- 5 criteria had substantial concurrence with clinical judgement (k = 0.855). When compared to the no neurocognitive disorder group, average neurofilament light concentrations were higher in both the mild and major neurocognitive disorder groups. DSM-5 neurocognitive disorder criteria can be used reliably in a Down syndrome population and has higher concurrence with clinical judgement than the older DSM-IV and ICD-10 criteria. Whilst the inter-rater reliability of the mild neurocognitive disorder criteria was modest, it does appear to identify people in an early stage of dementia with underlying neurodegenerative changes, represented by higher average NfL levels.
format	article
author	Sarah E. Pape Tamara al Janabi Nicholas J. Ashton Abdul Hye Rory Sheehan Paul Gallagher Bernice Knight Anne-Marije Prins Ken Courtenay Vesna Jordanova Bini Thomas Nagarajan Perumal Craig Forbes Angela Hassiotis Andre Strydom
author_facet	Sarah E. Pape Tamara al Janabi Nicholas J. Ashton Abdul Hye Rory Sheehan Paul Gallagher Bernice Knight Anne-Marije Prins Ken Courtenay Vesna Jordanova Bini Thomas Nagarajan Perumal Craig Forbes Angela Hassiotis Andre Strydom
author_sort	Sarah E. Pape
title	The reliability and validity of DSM 5 diagnostic criteria for neurocognitive disorder and relationship with plasma neurofilament light in a down syndrome population
title_short	The reliability and validity of DSM 5 diagnostic criteria for neurocognitive disorder and relationship with plasma neurofilament light in a down syndrome population
title_full	The reliability and validity of DSM 5 diagnostic criteria for neurocognitive disorder and relationship with plasma neurofilament light in a down syndrome population
title_fullStr	The reliability and validity of DSM 5 diagnostic criteria for neurocognitive disorder and relationship with plasma neurofilament light in a down syndrome population
title_full_unstemmed	The reliability and validity of DSM 5 diagnostic criteria for neurocognitive disorder and relationship with plasma neurofilament light in a down syndrome population
title_sort	reliability and validity of dsm 5 diagnostic criteria for neurocognitive disorder and relationship with plasma neurofilament light in a down syndrome population
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fd96eaea78ba49ceb19d5f682329bcbe
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The reliability and validity of DSM 5 diagnostic criteria for neurocognitive disorder and relationship with plasma neurofilament light in a down syndrome population

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