Mortality and risk factors associated with pulmonary embolism in coronavirus disease 2019 patients: a systematic review and meta-analysis

Mortality and risk factors associated with pulmonary embolism in coronavirus disease 2019 patients: a systematic review and meta-analysis

Abstract To determine, in patients with coronavirus disease 2019 (COVID-19) infection, the associations of pulmonary embolism (PE) with mortality and risk factors for PE as well as the therapeutic benefit of anticoagulant prophylaxis. Embase, PubMed, Cochrane controlled trials register, and Web of S...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Carlos Andrés Gómez, Cheuk-Kwan Sun, I-Ting Tsai, Yang-Pei Chang, Ming-Chung Lin, I-Yin Hung, Ying-Jen Chang, Li-Kai Wang, Yao-Tsung Lin, Kuo-Chuan Hung
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/fd97121a55a841c383b3de51f9ca7e7d
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:fd97121a55a841c383b3de51f9ca7e7d
record_format dspace
spelling oai:doaj.org-article:fd97121a55a841c383b3de51f9ca7e7d2021-12-02T18:49:21ZMortality and risk factors associated with pulmonary embolism in coronavirus disease 2019 patients: a systematic review and meta-analysis10.1038/s41598-021-95512-72045-2322https://doaj.org/article/fd97121a55a841c383b3de51f9ca7e7d2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95512-7https://doaj.org/toc/2045-2322Abstract To determine, in patients with coronavirus disease 2019 (COVID-19) infection, the associations of pulmonary embolism (PE) with mortality and risk factors for PE as well as the therapeutic benefit of anticoagulant prophylaxis. Embase, PubMed, Cochrane controlled trials register, and Web of Science databases were searched from inception to October 10, 2020. We included all published trials on PE in patients diagnosed with COVID-19 with eligibility of the trials assessed following the PRISMA guidelines. Sixteen clinical trials with 5826 patients were eligible. There were significant associations of PE with the male gender [odd ratio (OR) = 1.59, 95% CI 1.28–1.97], mechanical ventilation (OR = 3.71, 95% CI 2.57–5.36), intensive care unit admission (OR = 2.99, 95% CI 2.11–4.23), circulating D-dimer [mean difference (MD) = 5.04 µg/mL, 95% CI 3.67–6.42) and CRP (MD = 1.97 mg/dL, 95% CI 0.58– 3.35) concentrations without significant correlation between PE and mortality (OR = 1.31, 95% CI 0.82–2.08) as well as other parameters or comorbidities. After omitting one trial with strict patient selection criteria for anticoagulant prophylaxis, significant prophylactic benefit was noted (OR = 0.31, 95% CI 0.1–0.91). Our findings identified the risk factors associated with PE in COVID-19 patients and supported the therapeutic benefit of anticoagulant prophylaxis against PE in this patient population.Carlos Andrés GómezCheuk-Kwan SunI-Ting TsaiYang-Pei ChangMing-Chung LinI-Yin HungYing-Jen ChangLi-Kai WangYao-Tsung LinKuo-Chuan HungNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Carlos Andrés Gómez
Cheuk-Kwan Sun
I-Ting Tsai
Yang-Pei Chang
Ming-Chung Lin
I-Yin Hung
Ying-Jen Chang
Li-Kai Wang
Yao-Tsung Lin
Kuo-Chuan Hung
Mortality and risk factors associated with pulmonary embolism in coronavirus disease 2019 patients: a systematic review and meta-analysis
description Abstract To determine, in patients with coronavirus disease 2019 (COVID-19) infection, the associations of pulmonary embolism (PE) with mortality and risk factors for PE as well as the therapeutic benefit of anticoagulant prophylaxis. Embase, PubMed, Cochrane controlled trials register, and Web of Science databases were searched from inception to October 10, 2020. We included all published trials on PE in patients diagnosed with COVID-19 with eligibility of the trials assessed following the PRISMA guidelines. Sixteen clinical trials with 5826 patients were eligible. There were significant associations of PE with the male gender [odd ratio (OR) = 1.59, 95% CI 1.28–1.97], mechanical ventilation (OR = 3.71, 95% CI 2.57–5.36), intensive care unit admission (OR = 2.99, 95% CI 2.11–4.23), circulating D-dimer [mean difference (MD) = 5.04 µg/mL, 95% CI 3.67–6.42) and CRP (MD = 1.97 mg/dL, 95% CI 0.58– 3.35) concentrations without significant correlation between PE and mortality (OR = 1.31, 95% CI 0.82–2.08) as well as other parameters or comorbidities. After omitting one trial with strict patient selection criteria for anticoagulant prophylaxis, significant prophylactic benefit was noted (OR = 0.31, 95% CI 0.1–0.91). Our findings identified the risk factors associated with PE in COVID-19 patients and supported the therapeutic benefit of anticoagulant prophylaxis against PE in this patient population.
format article
author Carlos Andrés Gómez
Cheuk-Kwan Sun
I-Ting Tsai
Yang-Pei Chang
Ming-Chung Lin
I-Yin Hung
Ying-Jen Chang
Li-Kai Wang
Yao-Tsung Lin
Kuo-Chuan Hung
author_facet Carlos Andrés Gómez
Cheuk-Kwan Sun
I-Ting Tsai
Yang-Pei Chang
Ming-Chung Lin
I-Yin Hung
Ying-Jen Chang
Li-Kai Wang
Yao-Tsung Lin
Kuo-Chuan Hung
author_sort Carlos Andrés Gómez
title Mortality and risk factors associated with pulmonary embolism in coronavirus disease 2019 patients: a systematic review and meta-analysis
title_short Mortality and risk factors associated with pulmonary embolism in coronavirus disease 2019 patients: a systematic review and meta-analysis
title_full Mortality and risk factors associated with pulmonary embolism in coronavirus disease 2019 patients: a systematic review and meta-analysis
title_fullStr Mortality and risk factors associated with pulmonary embolism in coronavirus disease 2019 patients: a systematic review and meta-analysis
title_full_unstemmed Mortality and risk factors associated with pulmonary embolism in coronavirus disease 2019 patients: a systematic review and meta-analysis
title_sort mortality and risk factors associated with pulmonary embolism in coronavirus disease 2019 patients: a systematic review and meta-analysis
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/fd97121a55a841c383b3de51f9ca7e7d
work_keys_str_mv AT carlosandresgomez mortalityandriskfactorsassociatedwithpulmonaryembolismincoronavirusdisease2019patientsasystematicreviewandmetaanalysis
AT cheukkwansun mortalityandriskfactorsassociatedwithpulmonaryembolismincoronavirusdisease2019patientsasystematicreviewandmetaanalysis
AT itingtsai mortalityandriskfactorsassociatedwithpulmonaryembolismincoronavirusdisease2019patientsasystematicreviewandmetaanalysis
AT yangpeichang mortalityandriskfactorsassociatedwithpulmonaryembolismincoronavirusdisease2019patientsasystematicreviewandmetaanalysis
AT mingchunglin mortalityandriskfactorsassociatedwithpulmonaryembolismincoronavirusdisease2019patientsasystematicreviewandmetaanalysis
AT iyinhung mortalityandriskfactorsassociatedwithpulmonaryembolismincoronavirusdisease2019patientsasystematicreviewandmetaanalysis
AT yingjenchang mortalityandriskfactorsassociatedwithpulmonaryembolismincoronavirusdisease2019patientsasystematicreviewandmetaanalysis
AT likaiwang mortalityandriskfactorsassociatedwithpulmonaryembolismincoronavirusdisease2019patientsasystematicreviewandmetaanalysis
AT yaotsunglin mortalityandriskfactorsassociatedwithpulmonaryembolismincoronavirusdisease2019patientsasystematicreviewandmetaanalysis
AT kuochuanhung mortalityandriskfactorsassociatedwithpulmonaryembolismincoronavirusdisease2019patientsasystematicreviewandmetaanalysis
_version_ 1718377601060306944

Ejemplares similares