Evaluation of serum lipid profile, body mass index, and waistline in Chinese patients with type 2 diabetes mellitus

Rongtao Cui,1 Zhiming Qi,2 Lin Zhou,2 Zuohong Li,2 Qing Li,2 Junyong Zhang3 1Surgical Research, Department of Orthopedic and Trauma Surgery, Duisburg-Essen University Hospital, Essen, Germany; 2Department of Orthopedics, Dalian Central Hospital, Dalian, 3Department of Gastroenterology, Shandong Pro...

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Autores principales:	Cui RT, Qi ZM, Zhou L, Li ZH, Li Q, Zhang JY
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Body mass index waistline serum lipid profile type 2 diabetes mellitus Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/fd9743dad21a4ad38bc54131e0647d70
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spelling	oai:doaj.org-article:fd9743dad21a4ad38bc54131e0647d702021-12-02T07:45:31ZEvaluation of serum lipid profile, body mass index, and waistline in Chinese patients with type 2 diabetes mellitus1178-1998https://doaj.org/article/fd9743dad21a4ad38bc54131e0647d702016-04-01T00:00:00Zhttps://www.dovepress.com/evaluation-of-serum-lipid-profile-body-mass-index-and-waistline-in-chi-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Rongtao Cui,1 Zhiming Qi,2 Lin Zhou,2 Zuohong Li,2 Qing Li,2 Junyong Zhang3 1Surgical Research, Department of Orthopedic and Trauma Surgery, Duisburg-Essen University Hospital, Essen, Germany; 2Department of Orthopedics, Dalian Central Hospital, Dalian, 3Department of Gastroenterology, Shandong Provincial Hospital, Jinan, People’s Republic of China Objective: People with type 2 diabetes are at an increased risk of hypertension, arteriosclerosis, heart disease, and stroke. Glucose intolerance (insulin resistance) is the main feature of type 2 diabetes. Obesity leads to insulin resistance, dyslipidemia, etc. The aim of this study was to assess the biochemical parameters and measures of obesity in type 2 diabetes mellitus (T2DM).Methods: A total of 2,273 males and 6,547 females previously healthy volunteers (aged 41–95 years old) were recruited by open invitation. The basic information, including age, sex, height, weight, body mass index (BMI), waistline, hipline, menstrual cycle, and medical history, was collected by questionnaire survey and physical examination. Serum lipid profile, liver transaminase, blood glucose, postprandial blood glucose, and hemoglobin A1c were obtained after 12 hours of fasting.Results: According to our results, diabetic patients presented serum lipid abnormality. Elevated triglyceride (TG) levels (≥1.7 mmol/L) were noted in 19.69% of males and 20.40% of females, and reduced high-density lipoprotein cholesterol (HDL-C) levels (≤1.15 mmol/L) were noted in 21.96% of males and 15.74% of females. The combination of elevated TG and reduced HDL-C was the most prevalent of the combined lipid abnormalities. In contrast, no differences were observed in the levels of low-density lipoprotein cholesterol and total cholesterol. Moreover, there were statistically significant differences in the levels of BMI and waistline between T2DM and non-T2DM participants. After adjustment for BMI, logistic regression analysis revealed that the subjects with BMI ≤20 kg/m2 and >30 kg/m2 had a significantly elevated hazard ratio of T2DM compared with participants having a BMI range of 20 –30 kg/m2 in both males and females. However, there was a significant difference between T2DM patients and non-T2DM patients in waistline (χ2=8.57, P<0.001) than in BMI parameter (χ2=6.29, P<0.001).Conclusion: The present study shows for the first time that low levels of HDL-C, high levels of TG, and abnormal levels in BMI and waistline increase the risk of type 2 T2DM in Chinese people. Keywords: risk assessment, body mass index, waistline, HDL-C, TG, T2DMCui RTQi ZMZhou LLi ZHLi QZhang JYDove Medical PressarticleBody mass indexwaistlineserum lipid profiletype 2 diabetes mellitusGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 11, Pp 445-452 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Body mass index waistline serum lipid profile type 2 diabetes mellitus Geriatrics RC952-954.6
spellingShingle	Body mass index waistline serum lipid profile type 2 diabetes mellitus Geriatrics RC952-954.6 Cui RT Qi ZM Zhou L Li ZH Li Q Zhang JY Evaluation of serum lipid profile, body mass index, and waistline in Chinese patients with type 2 diabetes mellitus
description	Rongtao Cui,1 Zhiming Qi,2 Lin Zhou,2 Zuohong Li,2 Qing Li,2 Junyong Zhang3 1Surgical Research, Department of Orthopedic and Trauma Surgery, Duisburg-Essen University Hospital, Essen, Germany; 2Department of Orthopedics, Dalian Central Hospital, Dalian, 3Department of Gastroenterology, Shandong Provincial Hospital, Jinan, People’s Republic of China Objective: People with type 2 diabetes are at an increased risk of hypertension, arteriosclerosis, heart disease, and stroke. Glucose intolerance (insulin resistance) is the main feature of type 2 diabetes. Obesity leads to insulin resistance, dyslipidemia, etc. The aim of this study was to assess the biochemical parameters and measures of obesity in type 2 diabetes mellitus (T2DM).Methods: A total of 2,273 males and 6,547 females previously healthy volunteers (aged 41–95 years old) were recruited by open invitation. The basic information, including age, sex, height, weight, body mass index (BMI), waistline, hipline, menstrual cycle, and medical history, was collected by questionnaire survey and physical examination. Serum lipid profile, liver transaminase, blood glucose, postprandial blood glucose, and hemoglobin A1c were obtained after 12 hours of fasting.Results: According to our results, diabetic patients presented serum lipid abnormality. Elevated triglyceride (TG) levels (≥1.7 mmol/L) were noted in 19.69% of males and 20.40% of females, and reduced high-density lipoprotein cholesterol (HDL-C) levels (≤1.15 mmol/L) were noted in 21.96% of males and 15.74% of females. The combination of elevated TG and reduced HDL-C was the most prevalent of the combined lipid abnormalities. In contrast, no differences were observed in the levels of low-density lipoprotein cholesterol and total cholesterol. Moreover, there were statistically significant differences in the levels of BMI and waistline between T2DM and non-T2DM participants. After adjustment for BMI, logistic regression analysis revealed that the subjects with BMI ≤20 kg/m2 and >30 kg/m2 had a significantly elevated hazard ratio of T2DM compared with participants having a BMI range of 20 –30 kg/m2 in both males and females. However, there was a significant difference between T2DM patients and non-T2DM patients in waistline (χ2=8.57, P<0.001) than in BMI parameter (χ2=6.29, P<0.001).Conclusion: The present study shows for the first time that low levels of HDL-C, high levels of TG, and abnormal levels in BMI and waistline increase the risk of type 2 T2DM in Chinese people. Keywords: risk assessment, body mass index, waistline, HDL-C, TG, T2DM
format	article
author	Cui RT Qi ZM Zhou L Li ZH Li Q Zhang JY
author_facet	Cui RT Qi ZM Zhou L Li ZH Li Q Zhang JY
author_sort	Cui RT
title	Evaluation of serum lipid profile, body mass index, and waistline in Chinese patients with type 2 diabetes mellitus
title_short	Evaluation of serum lipid profile, body mass index, and waistline in Chinese patients with type 2 diabetes mellitus
title_full	Evaluation of serum lipid profile, body mass index, and waistline in Chinese patients with type 2 diabetes mellitus
title_fullStr	Evaluation of serum lipid profile, body mass index, and waistline in Chinese patients with type 2 diabetes mellitus
title_full_unstemmed	Evaluation of serum lipid profile, body mass index, and waistline in Chinese patients with type 2 diabetes mellitus
title_sort	evaluation of serum lipid profile, body mass index, and waistline in chinese patients with type 2 diabetes mellitus
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/fd9743dad21a4ad38bc54131e0647d70
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Evaluation of serum lipid profile, body mass index, and waistline in Chinese patients with type 2 diabetes mellitus

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