Impact of pregnancy-associated malaria on infant malaria infection in southern Benin.

<h4>Background</h4>Infants of mothers with placental Plasmodium falciparum infections at delivery are themselves more susceptible to malaria attacks or to infection in early life.<h4>Methodology/ principal findings</h4>To assess the impact of either the timing or the number o...

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Autores principales:	Sophie Borgella, Nadine Fievet, Bich-Tram Huynh, Samad Ibitokou, Gbetognon Hounguevou, Jacqueline Affedjou, Jean-Claude Sagbo, Parfait Houngbegnon, Blaise Guezo-Mévo, Achille Massougbodji, Adrian J F Luty, Michel Cot, Philippe Deloron
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fd988503be04435b8c03ff6dbf6d21cd
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spelling	oai:doaj.org-article:fd988503be04435b8c03ff6dbf6d21cd2021-11-18T08:46:41ZImpact of pregnancy-associated malaria on infant malaria infection in southern Benin.1932-620310.1371/journal.pone.0080624https://doaj.org/article/fd988503be04435b8c03ff6dbf6d21cd2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24236190/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Infants of mothers with placental Plasmodium falciparum infections at delivery are themselves more susceptible to malaria attacks or to infection in early life.<h4>Methodology/ principal findings</h4>To assess the impact of either the timing or the number of pregnancy-associated malaria (PAM) infections on the incidence of parasitemia or malaria attacks in infancy, we followed 218 mothers through pregnancy (monthly visits) up to delivery and their infants from birth to 12 months of age (fortnightly visits), collecting detailed clinical and parasitological data. After adjustment on location, mother's age, birth season, bed net use, and placental malaria, infants born to a mother with PAM during the third trimester of pregnancy had a significantly increased risk of infection (OR [95% CI]: 4.2 [1.6; 10.5], p = 0.003) or of malaria attack (4.6 [1.7; 12.5], p = 0.003). PAM during the first and second trimesters had no such impact. Similarly significant results were found for the effect of the overall number of PAM episodes on the time to first parasitemia and first malaria attack (HR [95% CI]: 2.95 [1.58; 5.50], p = 0.001 and 3.19 [1.59; 6.38], p = 0.001) respectively.<h4>Conclusions/ significance</h4>This study highlights the importance of protecting newborns by preventing repeated episodes of PAM in their mothers.Sophie BorgellaNadine FievetBich-Tram HuynhSamad IbitokouGbetognon HounguevouJacqueline AffedjouJean-Claude SagboParfait HoungbegnonBlaise Guezo-MévoAchille MassougbodjiAdrian J F LutyMichel CotPhilippe DeloronPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e80624 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sophie Borgella Nadine Fievet Bich-Tram Huynh Samad Ibitokou Gbetognon Hounguevou Jacqueline Affedjou Jean-Claude Sagbo Parfait Houngbegnon Blaise Guezo-Mévo Achille Massougbodji Adrian J F Luty Michel Cot Philippe Deloron Impact of pregnancy-associated malaria on infant malaria infection in southern Benin.
description	<h4>Background</h4>Infants of mothers with placental Plasmodium falciparum infections at delivery are themselves more susceptible to malaria attacks or to infection in early life.<h4>Methodology/ principal findings</h4>To assess the impact of either the timing or the number of pregnancy-associated malaria (PAM) infections on the incidence of parasitemia or malaria attacks in infancy, we followed 218 mothers through pregnancy (monthly visits) up to delivery and their infants from birth to 12 months of age (fortnightly visits), collecting detailed clinical and parasitological data. After adjustment on location, mother's age, birth season, bed net use, and placental malaria, infants born to a mother with PAM during the third trimester of pregnancy had a significantly increased risk of infection (OR [95% CI]: 4.2 [1.6; 10.5], p = 0.003) or of malaria attack (4.6 [1.7; 12.5], p = 0.003). PAM during the first and second trimesters had no such impact. Similarly significant results were found for the effect of the overall number of PAM episodes on the time to first parasitemia and first malaria attack (HR [95% CI]: 2.95 [1.58; 5.50], p = 0.001 and 3.19 [1.59; 6.38], p = 0.001) respectively.<h4>Conclusions/ significance</h4>This study highlights the importance of protecting newborns by preventing repeated episodes of PAM in their mothers.
format	article
author	Sophie Borgella Nadine Fievet Bich-Tram Huynh Samad Ibitokou Gbetognon Hounguevou Jacqueline Affedjou Jean-Claude Sagbo Parfait Houngbegnon Blaise Guezo-Mévo Achille Massougbodji Adrian J F Luty Michel Cot Philippe Deloron
author_facet	Sophie Borgella Nadine Fievet Bich-Tram Huynh Samad Ibitokou Gbetognon Hounguevou Jacqueline Affedjou Jean-Claude Sagbo Parfait Houngbegnon Blaise Guezo-Mévo Achille Massougbodji Adrian J F Luty Michel Cot Philippe Deloron
author_sort	Sophie Borgella
title	Impact of pregnancy-associated malaria on infant malaria infection in southern Benin.
title_short	Impact of pregnancy-associated malaria on infant malaria infection in southern Benin.
title_full	Impact of pregnancy-associated malaria on infant malaria infection in southern Benin.
title_fullStr	Impact of pregnancy-associated malaria on infant malaria infection in southern Benin.
title_full_unstemmed	Impact of pregnancy-associated malaria on infant malaria infection in southern Benin.
title_sort	impact of pregnancy-associated malaria on infant malaria infection in southern benin.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/fd988503be04435b8c03ff6dbf6d21cd
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Impact of pregnancy-associated malaria on infant malaria infection in southern Benin.

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