Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling

Lactate is a by-product of glycolysis that can function via its G protein receptor GPR81. Here the authors show that LPS or Salmonella infection enhances glycolytic metabolism in bone marrow neutrophils, resulting in lactate production, which increases endothelial barrier permeability and mobilizati...

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Autores principales:	Eman Khatib-Massalha, Suditi Bhattacharya, Hassan Massalha, Adi Biram, Karin Golan, Orit Kollet, Anju Kumari, Francesca Avemaria, Ekaterina Petrovich-Kopitman, Shiri Gur-Cohen, Tomer Itkin, Isabell Brandenburger, Asaf Spiegel, Ziv Shulman, Zachary Gerhart-Hines, Shalev Itzkovitz, Matthias Gunzer, Stefan Offermanns, Ronen Alon, Amiram Ariel, Tsvee Lapidot
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fd9905e2c6a74145a36f74cbae797fa7
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spelling	oai:doaj.org-article:fd9905e2c6a74145a36f74cbae797fa72021-12-02T17:01:15ZLactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling10.1038/s41467-020-17402-22041-1723https://doaj.org/article/fd9905e2c6a74145a36f74cbae797fa72020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17402-2https://doaj.org/toc/2041-1723Lactate is a by-product of glycolysis that can function via its G protein receptor GPR81. Here the authors show that LPS or Salmonella infection enhances glycolytic metabolism in bone marrow neutrophils, resulting in lactate production, which increases endothelial barrier permeability and mobilization of these neutrophils by targeting endothelial GPR81.Eman Khatib-MassalhaSuditi BhattacharyaHassan MassalhaAdi BiramKarin GolanOrit KolletAnju KumariFrancesca AvemariaEkaterina Petrovich-KopitmanShiri Gur-CohenTomer ItkinIsabell BrandenburgerAsaf SpiegelZiv ShulmanZachary Gerhart-HinesShalev ItzkovitzMatthias GunzerStefan OffermannsRonen AlonAmiram ArielTsvee LapidotNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eman Khatib-Massalha Suditi Bhattacharya Hassan Massalha Adi Biram Karin Golan Orit Kollet Anju Kumari Francesca Avemaria Ekaterina Petrovich-Kopitman Shiri Gur-Cohen Tomer Itkin Isabell Brandenburger Asaf Spiegel Ziv Shulman Zachary Gerhart-Hines Shalev Itzkovitz Matthias Gunzer Stefan Offermanns Ronen Alon Amiram Ariel Tsvee Lapidot Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling
description	Lactate is a by-product of glycolysis that can function via its G protein receptor GPR81. Here the authors show that LPS or Salmonella infection enhances glycolytic metabolism in bone marrow neutrophils, resulting in lactate production, which increases endothelial barrier permeability and mobilization of these neutrophils by targeting endothelial GPR81.
format	article
author	Eman Khatib-Massalha Suditi Bhattacharya Hassan Massalha Adi Biram Karin Golan Orit Kollet Anju Kumari Francesca Avemaria Ekaterina Petrovich-Kopitman Shiri Gur-Cohen Tomer Itkin Isabell Brandenburger Asaf Spiegel Ziv Shulman Zachary Gerhart-Hines Shalev Itzkovitz Matthias Gunzer Stefan Offermanns Ronen Alon Amiram Ariel Tsvee Lapidot
author_facet	Eman Khatib-Massalha Suditi Bhattacharya Hassan Massalha Adi Biram Karin Golan Orit Kollet Anju Kumari Francesca Avemaria Ekaterina Petrovich-Kopitman Shiri Gur-Cohen Tomer Itkin Isabell Brandenburger Asaf Spiegel Ziv Shulman Zachary Gerhart-Hines Shalev Itzkovitz Matthias Gunzer Stefan Offermanns Ronen Alon Amiram Ariel Tsvee Lapidot
author_sort	Eman Khatib-Massalha
title	Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling
title_short	Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling
title_full	Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling
title_fullStr	Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling
title_full_unstemmed	Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling
title_sort	lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial gpr81 signaling
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/fd9905e2c6a74145a36f74cbae797fa7
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Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling

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