FABP3-mediated membrane lipid saturation alters fluidity and induces ER stress in skeletal muscle with aging

Ageing leads to a loss of muscle mass and strength, called sarcopenia. Here, the authors show that fatty acid binding protein 3 (FABP3), a lipid chaperone, drives age-dependent lipidome remodeling in skeletal muscle and deteriorates muscle mass and contractility by modulating membrane fluidity and E...

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Autores principales:	Seung-Min Lee, Seol Hee Lee, Youngae Jung, Younglang Lee, Jong Hyun Yoon, Jeong Yi Choi, Chae Young Hwang, Young Hoon Son, Sung Sup Park, Geum-Sook Hwang, Kwang-Pyo Lee, Ki-Sun Kwon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fd99792e3593409b8c42a763dceb5467
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spelling	oai:doaj.org-article:fd99792e3593409b8c42a763dceb54672021-12-02T15:39:26ZFABP3-mediated membrane lipid saturation alters fluidity and induces ER stress in skeletal muscle with aging10.1038/s41467-020-19501-62041-1723https://doaj.org/article/fd99792e3593409b8c42a763dceb54672020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19501-6https://doaj.org/toc/2041-1723Ageing leads to a loss of muscle mass and strength, called sarcopenia. Here, the authors show that fatty acid binding protein 3 (FABP3), a lipid chaperone, drives age-dependent lipidome remodeling in skeletal muscle and deteriorates muscle mass and contractility by modulating membrane fluidity and ER stress signaling.Seung-Min LeeSeol Hee LeeYoungae JungYounglang LeeJong Hyun YoonJeong Yi ChoiChae Young HwangYoung Hoon SonSung Sup ParkGeum-Sook HwangKwang-Pyo LeeKi-Sun KwonNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Seung-Min Lee Seol Hee Lee Youngae Jung Younglang Lee Jong Hyun Yoon Jeong Yi Choi Chae Young Hwang Young Hoon Son Sung Sup Park Geum-Sook Hwang Kwang-Pyo Lee Ki-Sun Kwon FABP3-mediated membrane lipid saturation alters fluidity and induces ER stress in skeletal muscle with aging
description	Ageing leads to a loss of muscle mass and strength, called sarcopenia. Here, the authors show that fatty acid binding protein 3 (FABP3), a lipid chaperone, drives age-dependent lipidome remodeling in skeletal muscle and deteriorates muscle mass and contractility by modulating membrane fluidity and ER stress signaling.
format	article
author	Seung-Min Lee Seol Hee Lee Youngae Jung Younglang Lee Jong Hyun Yoon Jeong Yi Choi Chae Young Hwang Young Hoon Son Sung Sup Park Geum-Sook Hwang Kwang-Pyo Lee Ki-Sun Kwon
author_facet	Seung-Min Lee Seol Hee Lee Youngae Jung Younglang Lee Jong Hyun Yoon Jeong Yi Choi Chae Young Hwang Young Hoon Son Sung Sup Park Geum-Sook Hwang Kwang-Pyo Lee Ki-Sun Kwon
author_sort	Seung-Min Lee
title	FABP3-mediated membrane lipid saturation alters fluidity and induces ER stress in skeletal muscle with aging
title_short	FABP3-mediated membrane lipid saturation alters fluidity and induces ER stress in skeletal muscle with aging
title_full	FABP3-mediated membrane lipid saturation alters fluidity and induces ER stress in skeletal muscle with aging
title_fullStr	FABP3-mediated membrane lipid saturation alters fluidity and induces ER stress in skeletal muscle with aging
title_full_unstemmed	FABP3-mediated membrane lipid saturation alters fluidity and induces ER stress in skeletal muscle with aging
title_sort	fabp3-mediated membrane lipid saturation alters fluidity and induces er stress in skeletal muscle with aging
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/fd99792e3593409b8c42a763dceb5467
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FABP3-mediated membrane lipid saturation alters fluidity and induces ER stress in skeletal muscle with aging

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