FABP3-mediated membrane lipid saturation alters fluidity and induces ER stress in skeletal muscle with aging

FABP3-mediated membrane lipid saturation alters fluidity and induces ER stress in skeletal muscle with aging

Ageing leads to a loss of muscle mass and strength, called sarcopenia. Here, the authors show that fatty acid binding protein 3 (FABP3), a lipid chaperone, drives age-dependent lipidome remodeling in skeletal muscle and deteriorates muscle mass and contractility by modulating membrane fluidity and E...

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Main Authors: Seung-Min Lee, Seol Hee Lee, Youngae Jung, Younglang Lee, Jong Hyun Yoon, Jeong Yi Choi, Chae Young Hwang, Young Hoon Son, Sung Sup Park, Geum-Sook Hwang, Kwang-Pyo Lee, Ki-Sun Kwon
Format: article
Language:EN
Published: Nature Portfolio 2020
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Science
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Online Access:https://doaj.org/article/fd99792e3593409b8c42a763dceb5467
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https://doaj.org/article/fd99792e3593409b8c42a763dceb5467

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