Selecting The Best Treatment Option For A Dog With Cushing’S Syndrome

Spontaneous hypercortisolism or Cushing's syndrome is a common endocrinopathy in dogs. Pituitary-dependent and adrenal-dependent hypercortisolism each require specific treatment and diagnostic imaging is very helpful in choosing the treatment that is appropriate. The aims and expectations of th...

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Autor principal:	Sara GALAC
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2015
Materias:	hypophysectomy adrenalectomy trilostane mitotane dogs Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/fda07771785749e38ac4f1c4f80237c3
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id	oai:doaj.org-article:fda07771785749e38ac4f1c4f80237c3
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spelling	oai:doaj.org-article:fda07771785749e38ac4f1c4f80237c32021-11-17T21:27:50ZSelecting The Best Treatment Option For A Dog With Cushing’S Syndrome1820-744810.1515/acve-2015-0001https://doaj.org/article/fda07771785749e38ac4f1c4f80237c32015-03-01T00:00:00Zhttps://doi.org/10.1515/acve-2015-0001https://doaj.org/toc/1820-7448Spontaneous hypercortisolism or Cushing's syndrome is a common endocrinopathy in dogs. Pituitary-dependent and adrenal-dependent hypercortisolism each require specific treatment and diagnostic imaging is very helpful in choosing the treatment that is appropriate. The aims and expectations of the treatment need to be established beforehand and discussed with the owner to avoid unexpected disappointments. The clinical signs of pituitary-dependent hypercortisolism caused by a pituitary microadenoma can be managed with the adrenocorticostatic drug trilostane, but the drug will not affect the pituitary tumor. Hypophysectomy is therefore preferred in those dogs that have an enlarged pituitary but are in good clinical condition and have a long life-expectancy. Inoperable pituitary tumors can be treated by radiotherapy. The best treatment in dogs with cortisol-secreting adrenocortical tumors is adrenalectomy. If surgery is not possible, because of vascular invasion or metastatic spread, mitotane is recommended. Treatment with trilostane can be considered but is only palliative: it does not affect the adrenocortical tumor.Sara GALACSciendoarticlehypophysectomyadrenalectomytrilostanemitotanedogsVeterinary medicineSF600-1100ENActa Veterinaria, Vol 65, Iss 1, Pp 1-19 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	hypophysectomy adrenalectomy trilostane mitotane dogs Veterinary medicine SF600-1100
spellingShingle	hypophysectomy adrenalectomy trilostane mitotane dogs Veterinary medicine SF600-1100 Sara GALAC Selecting The Best Treatment Option For A Dog With Cushing’S Syndrome
description	Spontaneous hypercortisolism or Cushing's syndrome is a common endocrinopathy in dogs. Pituitary-dependent and adrenal-dependent hypercortisolism each require specific treatment and diagnostic imaging is very helpful in choosing the treatment that is appropriate. The aims and expectations of the treatment need to be established beforehand and discussed with the owner to avoid unexpected disappointments. The clinical signs of pituitary-dependent hypercortisolism caused by a pituitary microadenoma can be managed with the adrenocorticostatic drug trilostane, but the drug will not affect the pituitary tumor. Hypophysectomy is therefore preferred in those dogs that have an enlarged pituitary but are in good clinical condition and have a long life-expectancy. Inoperable pituitary tumors can be treated by radiotherapy. The best treatment in dogs with cortisol-secreting adrenocortical tumors is adrenalectomy. If surgery is not possible, because of vascular invasion or metastatic spread, mitotane is recommended. Treatment with trilostane can be considered but is only palliative: it does not affect the adrenocortical tumor.
format	article
author	Sara GALAC
author_facet	Sara GALAC
author_sort	Sara GALAC
title	Selecting The Best Treatment Option For A Dog With Cushing’S Syndrome
title_short	Selecting The Best Treatment Option For A Dog With Cushing’S Syndrome
title_full	Selecting The Best Treatment Option For A Dog With Cushing’S Syndrome
title_fullStr	Selecting The Best Treatment Option For A Dog With Cushing’S Syndrome
title_full_unstemmed	Selecting The Best Treatment Option For A Dog With Cushing’S Syndrome
title_sort	selecting the best treatment option for a dog with cushing’s syndrome
publisher	Sciendo
publishDate	2015
url	https://doaj.org/article/fda07771785749e38ac4f1c4f80237c3
work_keys_str_mv	AT saragalac selectingthebesttreatmentoptionforadogwithcushingssyndrome
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Selecting The Best Treatment Option For A Dog With Cushing’S Syndrome

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