Transplantation of Human Pluripotent Stem Cell-Derived Cardiomyocytes for Cardiac Regenerative Therapy

Cardiovascular disease is the leading cause of death worldwide and bears an immense economic burden. Late-stage heart failure often requires total heart transplantation; however, due to donor shortages and lifelong immunosuppression, alternative cardiac regenerative therapies are in high demand. Hum...

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Autores principales:	Sophia E. Silver, Ryan W. Barrs, Ying Mei
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	human pluripotent stem cell-derived cardiomyocytes cardiovascular disease cell therapy regenerative medicine tissue engineering Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/fda1131cedf04c25b725c5d378461664
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spelling	oai:doaj.org-article:fda1131cedf04c25b725c5d3784616642021-11-08T06:26:00ZTransplantation of Human Pluripotent Stem Cell-Derived Cardiomyocytes for Cardiac Regenerative Therapy2297-055X10.3389/fcvm.2021.707890https://doaj.org/article/fda1131cedf04c25b725c5d3784616642021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.707890/fullhttps://doaj.org/toc/2297-055XCardiovascular disease is the leading cause of death worldwide and bears an immense economic burden. Late-stage heart failure often requires total heart transplantation; however, due to donor shortages and lifelong immunosuppression, alternative cardiac regenerative therapies are in high demand. Human pluripotent stem cells (hPSCs), including human embryonic and induced pluripotent stem cells, have emerged as a viable source of human cardiomyocytes for transplantation. Recent developments in several mammalian models of cardiac injury have provided strong evidence of the therapeutic potential of hPSC-derived cardiomyocytes (hPSC-CM), showing their ability to electromechanically integrate with host cardiac tissue and promote functional recovery. In this review, we will discuss recent developments in hPSC-CM differentiation and transplantation strategies for delivery to the heart. We will highlight the mechanisms through which hPSC-CMs contribute to heart repair, review major challenges in successful transplantation of hPSC-CMs, and present solutions that are being explored to address these limitations. We end with a discussion of the clinical use of hPSC-CMs, including hurdles to clinical translation, current clinical trials, and future perspectives on hPSC-CM transplantation.Sophia E. SilverSophia E. SilverRyan W. BarrsRyan W. BarrsYing MeiYing MeiFrontiers Media S.A.articlehuman pluripotent stem cell-derived cardiomyocytescardiovascular diseasecell therapyregenerative medicinetissue engineeringDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	human pluripotent stem cell-derived cardiomyocytes cardiovascular disease cell therapy regenerative medicine tissue engineering Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	human pluripotent stem cell-derived cardiomyocytes cardiovascular disease cell therapy regenerative medicine tissue engineering Diseases of the circulatory (Cardiovascular) system RC666-701 Sophia E. Silver Sophia E. Silver Ryan W. Barrs Ryan W. Barrs Ying Mei Ying Mei Transplantation of Human Pluripotent Stem Cell-Derived Cardiomyocytes for Cardiac Regenerative Therapy
description	Cardiovascular disease is the leading cause of death worldwide and bears an immense economic burden. Late-stage heart failure often requires total heart transplantation; however, due to donor shortages and lifelong immunosuppression, alternative cardiac regenerative therapies are in high demand. Human pluripotent stem cells (hPSCs), including human embryonic and induced pluripotent stem cells, have emerged as a viable source of human cardiomyocytes for transplantation. Recent developments in several mammalian models of cardiac injury have provided strong evidence of the therapeutic potential of hPSC-derived cardiomyocytes (hPSC-CM), showing their ability to electromechanically integrate with host cardiac tissue and promote functional recovery. In this review, we will discuss recent developments in hPSC-CM differentiation and transplantation strategies for delivery to the heart. We will highlight the mechanisms through which hPSC-CMs contribute to heart repair, review major challenges in successful transplantation of hPSC-CMs, and present solutions that are being explored to address these limitations. We end with a discussion of the clinical use of hPSC-CMs, including hurdles to clinical translation, current clinical trials, and future perspectives on hPSC-CM transplantation.
format	article
author	Sophia E. Silver Sophia E. Silver Ryan W. Barrs Ryan W. Barrs Ying Mei Ying Mei
author_facet	Sophia E. Silver Sophia E. Silver Ryan W. Barrs Ryan W. Barrs Ying Mei Ying Mei
author_sort	Sophia E. Silver
title	Transplantation of Human Pluripotent Stem Cell-Derived Cardiomyocytes for Cardiac Regenerative Therapy
title_short	Transplantation of Human Pluripotent Stem Cell-Derived Cardiomyocytes for Cardiac Regenerative Therapy
title_full	Transplantation of Human Pluripotent Stem Cell-Derived Cardiomyocytes for Cardiac Regenerative Therapy
title_fullStr	Transplantation of Human Pluripotent Stem Cell-Derived Cardiomyocytes for Cardiac Regenerative Therapy
title_full_unstemmed	Transplantation of Human Pluripotent Stem Cell-Derived Cardiomyocytes for Cardiac Regenerative Therapy
title_sort	transplantation of human pluripotent stem cell-derived cardiomyocytes for cardiac regenerative therapy
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/fda1131cedf04c25b725c5d378461664
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Transplantation of Human Pluripotent Stem Cell-Derived Cardiomyocytes for Cardiac Regenerative Therapy

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