In vivo study of the effects of a portable cold plasma device and vitamin C for skin rejuvenation

Abstract Nowadays, cold atmospheric plasma shows interesting results in dermatology. In the present study, a new portable cold plasma was designed for plasma skin rejuvenation (PSR) purposes. This device is safe and easy to use at beauty salons and homes. The effects of this device were investigated...

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Autores principales:	Reza Shakouri, Mohammad Reza Khani, Shirin Samsavar, Mahya Aminrayai Jezeh, Fahimeh Abdollahimajd, Seyed Iman Hosseini, Aydin Dilmaghanian, Erfan Ghasemi, Mohammad Reza Alihoseini, Babak Shokri
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fda1a27cf53e47a0a6dbcbeeb4a49ca0
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spelling	oai:doaj.org-article:fda1a27cf53e47a0a6dbcbeeb4a49ca02021-11-14T12:20:54ZIn vivo study of the effects of a portable cold plasma device and vitamin C for skin rejuvenation10.1038/s41598-021-01341-z2045-2322https://doaj.org/article/fda1a27cf53e47a0a6dbcbeeb4a49ca02021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01341-zhttps://doaj.org/toc/2045-2322Abstract Nowadays, cold atmospheric plasma shows interesting results in dermatology. In the present study, a new portable cold plasma was designed for plasma skin rejuvenation (PSR) purposes. This device is safe and easy to use at beauty salons and homes. The effects of this device were investigated on the rat skins. Also, as a new method to improve PSR results, vitamin C ointment was combined with plasma. In this study, there were four groups of 5 Wistar rats. The first group received vitamin C ointment, the second received 5 min of high-voltage plasma, and the third and the fourth groups received 5 min of high- and low-voltage plasma and vitamin C ointment. This process was done every other day (3 sessions per week) for 6 weeks. To evaluate the thermal effect of plasma, the skin temperature was monitored. Also, the presence of reactive species was demonstrated by the use of optical spectroscopy. In addition, mechanical assays were performed to assess the effect of plasma and vitamin C on the tissue’s mechanical strength. The mechanical assays showed a positive impact of plasma on the treated tissue compared to the control group. Also, changes in the collagen level and thickness of the epidermal layer were examined in histological studies. The results indicated an increase in collagen levels after using plasma alone and an accelerated skin reaction after using vitamin C combined with plasma therapy. The epidermal layer’s thickness increased after applying high-voltage plasma, which indicates an increase in skin elasticity. This study demonstrates the positive effect of using the portable plasma device with vitamin C ointment on effective parameters in skin rejuvenation.Reza ShakouriMohammad Reza KhaniShirin SamsavarMahya Aminrayai JezehFahimeh AbdollahimajdSeyed Iman HosseiniAydin DilmaghanianErfan GhasemiMohammad Reza AlihoseiniBabak ShokriNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Reza Shakouri Mohammad Reza Khani Shirin Samsavar Mahya Aminrayai Jezeh Fahimeh Abdollahimajd Seyed Iman Hosseini Aydin Dilmaghanian Erfan Ghasemi Mohammad Reza Alihoseini Babak Shokri In vivo study of the effects of a portable cold plasma device and vitamin C for skin rejuvenation
description	Abstract Nowadays, cold atmospheric plasma shows interesting results in dermatology. In the present study, a new portable cold plasma was designed for plasma skin rejuvenation (PSR) purposes. This device is safe and easy to use at beauty salons and homes. The effects of this device were investigated on the rat skins. Also, as a new method to improve PSR results, vitamin C ointment was combined with plasma. In this study, there were four groups of 5 Wistar rats. The first group received vitamin C ointment, the second received 5 min of high-voltage plasma, and the third and the fourth groups received 5 min of high- and low-voltage plasma and vitamin C ointment. This process was done every other day (3 sessions per week) for 6 weeks. To evaluate the thermal effect of plasma, the skin temperature was monitored. Also, the presence of reactive species was demonstrated by the use of optical spectroscopy. In addition, mechanical assays were performed to assess the effect of plasma and vitamin C on the tissue’s mechanical strength. The mechanical assays showed a positive impact of plasma on the treated tissue compared to the control group. Also, changes in the collagen level and thickness of the epidermal layer were examined in histological studies. The results indicated an increase in collagen levels after using plasma alone and an accelerated skin reaction after using vitamin C combined with plasma therapy. The epidermal layer’s thickness increased after applying high-voltage plasma, which indicates an increase in skin elasticity. This study demonstrates the positive effect of using the portable plasma device with vitamin C ointment on effective parameters in skin rejuvenation.
format	article
author	Reza Shakouri Mohammad Reza Khani Shirin Samsavar Mahya Aminrayai Jezeh Fahimeh Abdollahimajd Seyed Iman Hosseini Aydin Dilmaghanian Erfan Ghasemi Mohammad Reza Alihoseini Babak Shokri
author_facet	Reza Shakouri Mohammad Reza Khani Shirin Samsavar Mahya Aminrayai Jezeh Fahimeh Abdollahimajd Seyed Iman Hosseini Aydin Dilmaghanian Erfan Ghasemi Mohammad Reza Alihoseini Babak Shokri
author_sort	Reza Shakouri
title	In vivo study of the effects of a portable cold plasma device and vitamin C for skin rejuvenation
title_short	In vivo study of the effects of a portable cold plasma device and vitamin C for skin rejuvenation
title_full	In vivo study of the effects of a portable cold plasma device and vitamin C for skin rejuvenation
title_fullStr	In vivo study of the effects of a portable cold plasma device and vitamin C for skin rejuvenation
title_full_unstemmed	In vivo study of the effects of a portable cold plasma device and vitamin C for skin rejuvenation
title_sort	in vivo study of the effects of a portable cold plasma device and vitamin c for skin rejuvenation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fda1a27cf53e47a0a6dbcbeeb4a49ca0
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In vivo study of the effects of a portable cold plasma device and vitamin C for skin rejuvenation

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