Functional versus morphological assessment of vascular age in patients with coronary heart disease

Abstract Communicating cardiovascular risk based on individual vascular age (VA) is a well acknowledged concept in patient education and disease prevention. VA may be derived functionally, e.g. by measurement of pulse wave velocity (PWV), or morphologically, e.g. by assessment of carotid intima-medi...

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Autores principales:	Tino Yurdadogan, Carolin Malsch, Kornelia Kotseva, David Wood, Rainer Leyh, Georg Ertl, Wolfgang Karmann, Lara Müller-Scholden, Caroline Morbach, Margret Breunig, Martin Wagner, Götz Gelbrich, Michiel L. Bots, Peter U. Heuschmann, Stefan Störk
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fda1eaa4029747db8ed22de202bb5025
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spelling	oai:doaj.org-article:fda1eaa4029747db8ed22de202bb50252021-12-02T18:02:30ZFunctional versus morphological assessment of vascular age in patients with coronary heart disease10.1038/s41598-021-96998-x2045-2322https://doaj.org/article/fda1eaa4029747db8ed22de202bb50252021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96998-xhttps://doaj.org/toc/2045-2322Abstract Communicating cardiovascular risk based on individual vascular age (VA) is a well acknowledged concept in patient education and disease prevention. VA may be derived functionally, e.g. by measurement of pulse wave velocity (PWV), or morphologically, e.g. by assessment of carotid intima-media thickness (cIMT). The purpose of this study was to investigate whether both approaches produce similar results. Within the context of the German subset of the EUROASPIRE IV survey, 501 patients with coronary heart disease underwent (a) oscillometric PWV measurement at the aortic, carotid-femoral and brachial-ankle site (PWVao, PWVcf, PWVba) and derivation of the aortic augmentation index (AIao); (b) bilateral cIMT assessment by high-resolution ultrasound at three sites (common, bulb, internal). Respective VA was calculated using published equations. According to VA derived from PWV, most patients exhibited values below chronological age indicating a counterintuitive healthier-than-anticipated vascular status: for VAPWVao in 68% of patients; for VAAIao in 52% of patients. By contrast, VA derived from cIMT delivered opposite results: e.g. according to VAtotal-cIMT accelerated vascular aging in 75% of patients. To strengthen the concept of VA, further efforts are needed to better standardise the current approaches to estimate VA and, thereby, to improve comparability and clinical utility.Tino YurdadoganCarolin MalschKornelia KotsevaDavid WoodRainer LeyhGeorg ErtlWolfgang KarmannLara Müller-ScholdenCaroline MorbachMargret BreunigMartin WagnerGötz GelbrichMichiel L. BotsPeter U. HeuschmannStefan StörkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tino Yurdadogan Carolin Malsch Kornelia Kotseva David Wood Rainer Leyh Georg Ertl Wolfgang Karmann Lara Müller-Scholden Caroline Morbach Margret Breunig Martin Wagner Götz Gelbrich Michiel L. Bots Peter U. Heuschmann Stefan Störk Functional versus morphological assessment of vascular age in patients with coronary heart disease
description	Abstract Communicating cardiovascular risk based on individual vascular age (VA) is a well acknowledged concept in patient education and disease prevention. VA may be derived functionally, e.g. by measurement of pulse wave velocity (PWV), or morphologically, e.g. by assessment of carotid intima-media thickness (cIMT). The purpose of this study was to investigate whether both approaches produce similar results. Within the context of the German subset of the EUROASPIRE IV survey, 501 patients with coronary heart disease underwent (a) oscillometric PWV measurement at the aortic, carotid-femoral and brachial-ankle site (PWVao, PWVcf, PWVba) and derivation of the aortic augmentation index (AIao); (b) bilateral cIMT assessment by high-resolution ultrasound at three sites (common, bulb, internal). Respective VA was calculated using published equations. According to VA derived from PWV, most patients exhibited values below chronological age indicating a counterintuitive healthier-than-anticipated vascular status: for VAPWVao in 68% of patients; for VAAIao in 52% of patients. By contrast, VA derived from cIMT delivered opposite results: e.g. according to VAtotal-cIMT accelerated vascular aging in 75% of patients. To strengthen the concept of VA, further efforts are needed to better standardise the current approaches to estimate VA and, thereby, to improve comparability and clinical utility.
format	article
author	Tino Yurdadogan Carolin Malsch Kornelia Kotseva David Wood Rainer Leyh Georg Ertl Wolfgang Karmann Lara Müller-Scholden Caroline Morbach Margret Breunig Martin Wagner Götz Gelbrich Michiel L. Bots Peter U. Heuschmann Stefan Störk
author_facet	Tino Yurdadogan Carolin Malsch Kornelia Kotseva David Wood Rainer Leyh Georg Ertl Wolfgang Karmann Lara Müller-Scholden Caroline Morbach Margret Breunig Martin Wagner Götz Gelbrich Michiel L. Bots Peter U. Heuschmann Stefan Störk
author_sort	Tino Yurdadogan
title	Functional versus morphological assessment of vascular age in patients with coronary heart disease
title_short	Functional versus morphological assessment of vascular age in patients with coronary heart disease
title_full	Functional versus morphological assessment of vascular age in patients with coronary heart disease
title_fullStr	Functional versus morphological assessment of vascular age in patients with coronary heart disease
title_full_unstemmed	Functional versus morphological assessment of vascular age in patients with coronary heart disease
title_sort	functional versus morphological assessment of vascular age in patients with coronary heart disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fda1eaa4029747db8ed22de202bb5025
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Functional versus morphological assessment of vascular age in patients with coronary heart disease

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