CONTENTS OF CYTOKINES IN BLOOD OF THE PATIENTS WITH LOCAL FROSTBITES

Abstract. Cytokines provide important connecting links between immunity, blood clotting, and nonspecific resistance that become altered in local frostbites. The aim of study was to determine the contents of cytokines in blood of patients with local frostbites at various terms following the lesion. F...

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Autores principales:	K. G. Shapovalov, E. A. Tomina, M. I. Mihailichenko, V. A. Sizonenko, Y. A. Vitkovsky
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	cytokines frostbite tnfα il-1β il-4 il-8 il-18 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/fda6254bc5e64c3db134df6983e2e0eb
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spelling	oai:doaj.org-article:fda6254bc5e64c3db134df6983e2e0eb2021-11-18T08:03:37ZCONTENTS OF CYTOKINES IN BLOOD OF THE PATIENTS WITH LOCAL FROSTBITES1563-06252313-741X10.15789/1563-0625-2008-1-89-92https://doaj.org/article/fda6254bc5e64c3db134df6983e2e0eb2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/87https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Cytokines provide important connecting links between immunity, blood clotting, and nonspecific resistance that become altered in local frostbites. The aim of study was to determine the contents of cytokines in blood of patients with local frostbites at various terms following the lesion. Fifty patients, 17 to 50 years old, with frostbites of extremities (grade II to IV) were under observation. Arterial and venous blood, as well as venous blood from damaged and intact extremities were examined. Cytokine concentrations were determined using ELISA technique. It was shown that blood concentrations of TNFα, IL-1β, IL-4, IL-8 and IL-18 reached their maximum at early reactive period of the trauma (a 2.3- to 19-fold increase). IL-1β concentration exceeded appropriate control values during all the periods of local frostbites. IL 18 levels were increased at early reactive period of the trauma. IL-1β and IL-8 concentration at pre-reactive period proved to be higher in arterial blood of damaged extremities, than in effluent venous blood. Both during early and late reactive periods, the levels of pro-inflammatory cytokines in effluent blood from damaged extremities were 1.2- to 8-fold higher than in venous blood from intact extremities, whereas IL-4 levels were 2- to 5-fold lower.K. G. ShapovalovE. A. TominaM. I. MihailichenkoV. A. SizonenkoY. A. VitkovskySPb RAACIarticlecytokinesfrostbitetnfαil-1βil-4il-8il-18Immunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 10, Iss 1, Pp 89-92 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	cytokines frostbite tnfα il-1β il-4 il-8 il-18 Immunologic diseases. Allergy RC581-607
spellingShingle	cytokines frostbite tnfα il-1β il-4 il-8 il-18 Immunologic diseases. Allergy RC581-607 K. G. Shapovalov E. A. Tomina M. I. Mihailichenko V. A. Sizonenko Y. A. Vitkovsky CONTENTS OF CYTOKINES IN BLOOD OF THE PATIENTS WITH LOCAL FROSTBITES
description	Abstract. Cytokines provide important connecting links between immunity, blood clotting, and nonspecific resistance that become altered in local frostbites. The aim of study was to determine the contents of cytokines in blood of patients with local frostbites at various terms following the lesion. Fifty patients, 17 to 50 years old, with frostbites of extremities (grade II to IV) were under observation. Arterial and venous blood, as well as venous blood from damaged and intact extremities were examined. Cytokine concentrations were determined using ELISA technique. It was shown that blood concentrations of TNFα, IL-1β, IL-4, IL-8 and IL-18 reached their maximum at early reactive period of the trauma (a 2.3- to 19-fold increase). IL-1β concentration exceeded appropriate control values during all the periods of local frostbites. IL 18 levels were increased at early reactive period of the trauma. IL-1β and IL-8 concentration at pre-reactive period proved to be higher in arterial blood of damaged extremities, than in effluent venous blood. Both during early and late reactive periods, the levels of pro-inflammatory cytokines in effluent blood from damaged extremities were 1.2- to 8-fold higher than in venous blood from intact extremities, whereas IL-4 levels were 2- to 5-fold lower.
format	article
author	K. G. Shapovalov E. A. Tomina M. I. Mihailichenko V. A. Sizonenko Y. A. Vitkovsky
author_facet	K. G. Shapovalov E. A. Tomina M. I. Mihailichenko V. A. Sizonenko Y. A. Vitkovsky
author_sort	K. G. Shapovalov
title	CONTENTS OF CYTOKINES IN BLOOD OF THE PATIENTS WITH LOCAL FROSTBITES
title_short	CONTENTS OF CYTOKINES IN BLOOD OF THE PATIENTS WITH LOCAL FROSTBITES
title_full	CONTENTS OF CYTOKINES IN BLOOD OF THE PATIENTS WITH LOCAL FROSTBITES
title_fullStr	CONTENTS OF CYTOKINES IN BLOOD OF THE PATIENTS WITH LOCAL FROSTBITES
title_full_unstemmed	CONTENTS OF CYTOKINES IN BLOOD OF THE PATIENTS WITH LOCAL FROSTBITES
title_sort	contents of cytokines in blood of the patients with local frostbites
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/fda6254bc5e64c3db134df6983e2e0eb
work_keys_str_mv	AT kgshapovalov contentsofcytokinesinbloodofthepatientswithlocalfrostbites AT eatomina contentsofcytokinesinbloodofthepatientswithlocalfrostbites AT mimihailichenko contentsofcytokinesinbloodofthepatientswithlocalfrostbites AT vasizonenko contentsofcytokinesinbloodofthepatientswithlocalfrostbites AT yavitkovsky contentsofcytokinesinbloodofthepatientswithlocalfrostbites
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CONTENTS OF CYTOKINES IN BLOOD OF THE PATIENTS WITH LOCAL FROSTBITES

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