Stochastic master equation for early protein aggregation in the transthyretin amyloid disease

Abstract It is significant to understand the earliest molecular events occurring in the nucleation of the amyloid aggregation cascade for the prevention of amyloid related diseases such as transthyretin amyloid disease. We develop chemical master equation for the aggregation of monomers into oligome...

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Autores principales:	Ruo-Nan Liu, Yan-Mei Kang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fdada9857a73460eb14fb984d9f8549b
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spelling	oai:doaj.org-article:fdada9857a73460eb14fb984d9f8549b2021-12-02T17:55:13ZStochastic master equation for early protein aggregation in the transthyretin amyloid disease10.1038/s41598-020-69319-x2045-2322https://doaj.org/article/fdada9857a73460eb14fb984d9f8549b2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-69319-xhttps://doaj.org/toc/2045-2322Abstract It is significant to understand the earliest molecular events occurring in the nucleation of the amyloid aggregation cascade for the prevention of amyloid related diseases such as transthyretin amyloid disease. We develop chemical master equation for the aggregation of monomers into oligomers using reaction rate law in chemical kinetics. For this stochastic model, lognormal moment closure method is applied to track the evolution of relevant statistical moments and its high accuracy is confirmed by the results obtained from Gillespie’s stochastic simulation algorithm. Our results show that the formation of oligomers is highly dependent on the number of monomers. Furthermore, the misfolding rate also has an important impact on the process of oligomers formation. The quantitative investigation should be helpful for shedding more light on the mechanism of amyloid fibril nucleation.Ruo-Nan LiuYan-Mei KangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ruo-Nan Liu Yan-Mei Kang Stochastic master equation for early protein aggregation in the transthyretin amyloid disease
description	Abstract It is significant to understand the earliest molecular events occurring in the nucleation of the amyloid aggregation cascade for the prevention of amyloid related diseases such as transthyretin amyloid disease. We develop chemical master equation for the aggregation of monomers into oligomers using reaction rate law in chemical kinetics. For this stochastic model, lognormal moment closure method is applied to track the evolution of relevant statistical moments and its high accuracy is confirmed by the results obtained from Gillespie’s stochastic simulation algorithm. Our results show that the formation of oligomers is highly dependent on the number of monomers. Furthermore, the misfolding rate also has an important impact on the process of oligomers formation. The quantitative investigation should be helpful for shedding more light on the mechanism of amyloid fibril nucleation.
format	article
author	Ruo-Nan Liu Yan-Mei Kang
author_facet	Ruo-Nan Liu Yan-Mei Kang
author_sort	Ruo-Nan Liu
title	Stochastic master equation for early protein aggregation in the transthyretin amyloid disease
title_short	Stochastic master equation for early protein aggregation in the transthyretin amyloid disease
title_full	Stochastic master equation for early protein aggregation in the transthyretin amyloid disease
title_fullStr	Stochastic master equation for early protein aggregation in the transthyretin amyloid disease
title_full_unstemmed	Stochastic master equation for early protein aggregation in the transthyretin amyloid disease
title_sort	stochastic master equation for early protein aggregation in the transthyretin amyloid disease
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/fdada9857a73460eb14fb984d9f8549b
work_keys_str_mv	AT ruonanliu stochasticmasterequationforearlyproteinaggregationinthetransthyretinamyloiddisease AT yanmeikang stochasticmasterequationforearlyproteinaggregationinthetransthyretinamyloiddisease
_version_	1718379147704664064

Stochastic master equation for early protein aggregation in the transthyretin amyloid disease

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