Targeting Autophagy in Dendritic Cells as a Mechanism to Limit Immunopathogenesis in Herpetic Stromal Keratitis

ABSTRACT In a recent mBio article, Y. Jiang, X. Yin, P. M. Stuart, and D. A. Lieb [mBio 6(6):e01426-15, 2015, doi:10.1128/mBio.01426-15] presented an elegant set of experiments that utilized a transgenic, knockout strain of mice whose dendritic cells (DCs) are incapable of undergoing autophagy, to d...

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Autor principal:	John A. Blaho
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2016
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/fdb2fb32e30244a8a6d09f01220bd28e
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spelling	oai:doaj.org-article:fdb2fb32e30244a8a6d09f01220bd28e2021-11-15T15:49:40ZTargeting Autophagy in Dendritic Cells as a Mechanism to Limit Immunopathogenesis in Herpetic Stromal Keratitis10.1128/mBio.02053-152150-7511https://doaj.org/article/fdb2fb32e30244a8a6d09f01220bd28e2016-03-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.02053-15https://doaj.org/toc/2150-7511ABSTRACT In a recent mBio article, Y. Jiang, X. Yin, P. M. Stuart, and D. A. Lieb [mBio 6(6):e01426-15, 2015, doi:10.1128/mBio.01426-15] presented an elegant set of experiments that utilized a transgenic, knockout strain of mice whose dendritic cells (DCs) are incapable of undergoing autophagy, to dissect out the aspects of the chronic inflammatory response following viral infection of corneal epithelial cells. The authors’ results provide a potential proof of concept that the DC autophagy pathway may be a valid target for therapeutic drug design in certain inflammatory pathologies.John A. BlahoAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 7, Iss 1 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 John A. Blaho Targeting Autophagy in Dendritic Cells as a Mechanism to Limit Immunopathogenesis in Herpetic Stromal Keratitis
description	ABSTRACT In a recent mBio article, Y. Jiang, X. Yin, P. M. Stuart, and D. A. Lieb [mBio 6(6):e01426-15, 2015, doi:10.1128/mBio.01426-15] presented an elegant set of experiments that utilized a transgenic, knockout strain of mice whose dendritic cells (DCs) are incapable of undergoing autophagy, to dissect out the aspects of the chronic inflammatory response following viral infection of corneal epithelial cells. The authors’ results provide a potential proof of concept that the DC autophagy pathway may be a valid target for therapeutic drug design in certain inflammatory pathologies.
format	article
author	John A. Blaho
author_facet	John A. Blaho
author_sort	John A. Blaho
title	Targeting Autophagy in Dendritic Cells as a Mechanism to Limit Immunopathogenesis in Herpetic Stromal Keratitis
title_short	Targeting Autophagy in Dendritic Cells as a Mechanism to Limit Immunopathogenesis in Herpetic Stromal Keratitis
title_full	Targeting Autophagy in Dendritic Cells as a Mechanism to Limit Immunopathogenesis in Herpetic Stromal Keratitis
title_fullStr	Targeting Autophagy in Dendritic Cells as a Mechanism to Limit Immunopathogenesis in Herpetic Stromal Keratitis
title_full_unstemmed	Targeting Autophagy in Dendritic Cells as a Mechanism to Limit Immunopathogenesis in Herpetic Stromal Keratitis
title_sort	targeting autophagy in dendritic cells as a mechanism to limit immunopathogenesis in herpetic stromal keratitis
publisher	American Society for Microbiology
publishDate	2016
url	https://doaj.org/article/fdb2fb32e30244a8a6d09f01220bd28e
work_keys_str_mv	AT johnablaho targetingautophagyindendriticcellsasamechanismtolimitimmunopathogenesisinherpeticstromalkeratitis
_version_	1718427499382177792

Targeting Autophagy in Dendritic Cells as a Mechanism to Limit Immunopathogenesis in Herpetic Stromal Keratitis

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