Toxicologic effects of gold nanoparticles in vivo by different administration routes

Xiao-Dong Zhang*, Hong-Ying Wu*, Di Wu, Yue-Ying Wang, Jian-Hui Chang, Zhi-Bin Zhai, Ai-Min Meng, Pei-Xun Liu, Liang-An Zhang, Fei-Yue FanInstitute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, and Tianjin Key Laboratory of Molecular Nuclear Medicine, T...

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Autores principales:	Xiao-Dong Zhang, Hong-Ying Wu, Di Wu, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/fdb3232bb31541aca840030046d598e0
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spelling	oai:doaj.org-article:fdb3232bb31541aca840030046d598e02021-12-02T07:45:54ZToxicologic effects of gold nanoparticles in vivo by different administration routes1176-91141178-2013https://doaj.org/article/fdb3232bb31541aca840030046d598e02010-09-01T00:00:00Zhttp://www.dovepress.com/toxicologic-effects-of-gold-nanoparticles-in-vivo-by-different-adminis-a5376https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Xiao-Dong Zhang, Hong-Ying Wu, Di Wu, Yue-Ying Wang, Jian-Hui Chang, Zhi-Bin Zhai, Ai-Min Meng, Pei-Xun Liu, Liang-An Zhang, Fei-Yue FanInstitute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, and Tianjin Key Laboratory of Molecular Nuclear Medicine, Tianjin, People&rsquo;s Republic of China *The authors contributed equally to this workAbstract: Gold nanoparticles have potential applications in biomedicine, but one of the important concerns is about their safety. Most toxicology data are derived from in vitro studies and may not reflect in vivo responses. Here, an animal toxicity study of 13.5 nm gold nanoparticles in mice is presented. Animal survival, weight, hematology, morphology, and organ index are characterized at different concentrations (137.5&ndash;2200 &micro;g/kg) over 14&ndash;28 days. The results show that low concentrations of gold nanoparticles do not cause an obvious decrease in body weight or appreciable toxicity, even after their breakdown in vivo. High concentrations of gold nanoparticles induced decreases in body weight, red blood cells, and hematocrit. It was also found that gold nanoparticles administered orally caused significant decreases in body weight, spleen index, and red blood cells. Of the three administration routes, the oral and intraperitoneal routes showed the highest toxicity, and the tail vein injection showed the lowest toxicity. Combining the results of all of these studies, we suggest that targeted gold nanopartices by tail vein injection may be suitable for enhancement of radiotherapy, photothermal therapy, and related medical diagnostic procedures.Keywords: gold nanoparticles, in vivo, toxicity Xiao-Dong ZhangHong-Ying WuDi Wuet alDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2010, Iss default, Pp 771-781 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Xiao-Dong Zhang Hong-Ying Wu Di Wu et al Toxicologic effects of gold nanoparticles in vivo by different administration routes
description	Xiao-Dong Zhang, Hong-Ying Wu, Di Wu, Yue-Ying Wang, Jian-Hui Chang, Zhi-Bin Zhai, Ai-Min Meng, Pei-Xun Liu, Liang-An Zhang, Fei-Yue FanInstitute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, and Tianjin Key Laboratory of Molecular Nuclear Medicine, Tianjin, People&rsquo;s Republic of China *The authors contributed equally to this workAbstract: Gold nanoparticles have potential applications in biomedicine, but one of the important concerns is about their safety. Most toxicology data are derived from in vitro studies and may not reflect in vivo responses. Here, an animal toxicity study of 13.5 nm gold nanoparticles in mice is presented. Animal survival, weight, hematology, morphology, and organ index are characterized at different concentrations (137.5&ndash;2200 &micro;g/kg) over 14&ndash;28 days. The results show that low concentrations of gold nanoparticles do not cause an obvious decrease in body weight or appreciable toxicity, even after their breakdown in vivo. High concentrations of gold nanoparticles induced decreases in body weight, red blood cells, and hematocrit. It was also found that gold nanoparticles administered orally caused significant decreases in body weight, spleen index, and red blood cells. Of the three administration routes, the oral and intraperitoneal routes showed the highest toxicity, and the tail vein injection showed the lowest toxicity. Combining the results of all of these studies, we suggest that targeted gold nanopartices by tail vein injection may be suitable for enhancement of radiotherapy, photothermal therapy, and related medical diagnostic procedures.Keywords: gold nanoparticles, in vivo, toxicity
format	article
author	Xiao-Dong Zhang Hong-Ying Wu Di Wu et al
author_facet	Xiao-Dong Zhang Hong-Ying Wu Di Wu et al
author_sort	Xiao-Dong Zhang
title	Toxicologic effects of gold nanoparticles in vivo by different administration routes
title_short	Toxicologic effects of gold nanoparticles in vivo by different administration routes
title_full	Toxicologic effects of gold nanoparticles in vivo by different administration routes
title_fullStr	Toxicologic effects of gold nanoparticles in vivo by different administration routes
title_full_unstemmed	Toxicologic effects of gold nanoparticles in vivo by different administration routes
title_sort	toxicologic effects of gold nanoparticles in vivo by different administration routes
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/fdb3232bb31541aca840030046d598e0
work_keys_str_mv	AT xiaodongzhang toxicologiceffectsofgoldnanoparticlesinvivobydifferentadministrationroutes AT hongyingwu toxicologiceffectsofgoldnanoparticlesinvivobydifferentadministrationroutes AT diwu toxicologiceffectsofgoldnanoparticlesinvivobydifferentadministrationroutes AT etal toxicologiceffectsofgoldnanoparticlesinvivobydifferentadministrationroutes
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Toxicologic effects of gold nanoparticles in vivo by different administration routes

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