Plasma complement component 4 increases in patients with major depressive disorder

Jinxue Wei,* Ye Liu,* Liansheng Zhao, Xiao Yang, Peiyan Ni, Yingcheng Wang, Tao Li, Xiaohong Ma Psychiatric Laboratory and Mental Health Center, Huaxi Brain Research Center, West China Hospital of Sichuan University, Chengdu, China *These authors contributed equally to this work Abstract: Elevati...

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Autores principales:	Wei J, Liu Y, Zhao L, Yang X, Ni P, Wang Y, Li T, Ma X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	major depressive disorder complement component 4 inflammatory factors Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/fdb3bdda310f47f89b58f411a6db34eb
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spelling	oai:doaj.org-article:fdb3bdda310f47f89b58f411a6db34eb2021-12-02T01:24:56ZPlasma complement component 4 increases in patients with major depressive disorder1178-2021https://doaj.org/article/fdb3bdda310f47f89b58f411a6db34eb2017-12-01T00:00:00Zhttps://www.dovepress.com/plasma-complement-component-4-increases-in-patients-with-major-depress-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Jinxue Wei,* Ye Liu,* Liansheng Zhao, Xiao Yang, Peiyan Ni, Yingcheng Wang, Tao Li, Xiaohong Ma Psychiatric Laboratory and Mental Health Center, Huaxi Brain Research Center, West China Hospital of Sichuan University, Chengdu, China *These authors contributed equally to this work Abstract: Elevation of plasma inflammatory factors in major depressive disorder (MDD) has been repeatedly observed, but contradictory results have also been reported. Alteration of complement components in MDD may also contribute to the pathophysiology of MDD by participating in inflammation. The recent findings that complement component 4 (C4) was involved in neural synapse elimination and associated with schizophrenia implicated the potential roles of C4 in MDD. In this study, we analyzed the plasma concentration of complement C4 and inflammatory factors, including interleukin (IL)-1β, IL-6, IL-8, IL-10, interferon-α, interferon-γ and tumor necrosis factor-α, of 53 patients with MDD and 60 healthy individuals. The plasma of 17 patients out of 51 after antidepressant medication was also collected for analysis. The results showed that peripheral C4 in MDD was higher than that in healthy controls. No significant correlation of inflammatory factors or C4 with depressive or anxiety symptoms was found. Antidepressant medication significantly reduced plasma C4 of patients with MDD. Our results were consistent with previous findings that complement components were elevated in MDD and suggested that C4 might play a role in pathophysiology of MDD and could be a candidate in the research of biomarker and the pathophysiology of MDD. Keywords: depression, C4, inflammationWei JLiu YZhao LYang XNi PWang YLi TMa XDove Medical Pressarticlemajor depressive disordercomplement component 4inflammatory factorsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 37-41 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	major depressive disorder complement component 4 inflammatory factors Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	major depressive disorder complement component 4 inflammatory factors Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Wei J Liu Y Zhao L Yang X Ni P Wang Y Li T Ma X Plasma complement component 4 increases in patients with major depressive disorder
description	Jinxue Wei,* Ye Liu,* Liansheng Zhao, Xiao Yang, Peiyan Ni, Yingcheng Wang, Tao Li, Xiaohong Ma Psychiatric Laboratory and Mental Health Center, Huaxi Brain Research Center, West China Hospital of Sichuan University, Chengdu, China *These authors contributed equally to this work Abstract: Elevation of plasma inflammatory factors in major depressive disorder (MDD) has been repeatedly observed, but contradictory results have also been reported. Alteration of complement components in MDD may also contribute to the pathophysiology of MDD by participating in inflammation. The recent findings that complement component 4 (C4) was involved in neural synapse elimination and associated with schizophrenia implicated the potential roles of C4 in MDD. In this study, we analyzed the plasma concentration of complement C4 and inflammatory factors, including interleukin (IL)-1β, IL-6, IL-8, IL-10, interferon-α, interferon-γ and tumor necrosis factor-α, of 53 patients with MDD and 60 healthy individuals. The plasma of 17 patients out of 51 after antidepressant medication was also collected for analysis. The results showed that peripheral C4 in MDD was higher than that in healthy controls. No significant correlation of inflammatory factors or C4 with depressive or anxiety symptoms was found. Antidepressant medication significantly reduced plasma C4 of patients with MDD. Our results were consistent with previous findings that complement components were elevated in MDD and suggested that C4 might play a role in pathophysiology of MDD and could be a candidate in the research of biomarker and the pathophysiology of MDD. Keywords: depression, C4, inflammation
format	article
author	Wei J Liu Y Zhao L Yang X Ni P Wang Y Li T Ma X
author_facet	Wei J Liu Y Zhao L Yang X Ni P Wang Y Li T Ma X
author_sort	Wei J
title	Plasma complement component 4 increases in patients with major depressive disorder
title_short	Plasma complement component 4 increases in patients with major depressive disorder
title_full	Plasma complement component 4 increases in patients with major depressive disorder
title_fullStr	Plasma complement component 4 increases in patients with major depressive disorder
title_full_unstemmed	Plasma complement component 4 increases in patients with major depressive disorder
title_sort	plasma complement component 4 increases in patients with major depressive disorder
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/fdb3bdda310f47f89b58f411a6db34eb
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Plasma complement component 4 increases in patients with major depressive disorder

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