Acadesine kills chronic myelogenous leukemia (CML) cells through PKC-dependent induction of autophagic cell death.

Acadesine kills chronic myelogenous leukemia (CML) cells through PKC-dependent induction of autophagic cell death.

CML is an hematopoietic stem cell disease characterized by the t(9;22) (q34;q11) translocation encoding the oncoprotein p210BCR-ABL. The effect of acadesine (AICAR, 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside) a compound with known antileukemic effect on B cell chronic lymphoblastic leuke...

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Bibliographic Details
Main Authors: Guillaume Robert, Issam Ben Sahra, Alexandre Puissant, Pascal Colosetti, Nathalie Belhacene, Pierre Gounon, Paul Hofman, Fréderic Bost, Jill-Patrice Cassuto, Patrick Auberger
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2009
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/fdb62ae3eb444b589d2b79bad894e00c
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