Learning the pattern of epistasis linking genotype and phenotype in a protein

Epistasis underlies the complexity of genotype-phenotype maps. Here, the authors analyze 8,192 mutants that link two phenotypically distinct variants of the Entacmaea quadricolor fluorescent protein, and show the existence, but also the sparsity, of high-order epistatic interactions.

Guardado en:

Detalles Bibliográficos
Autores principales:	Frank J. Poelwijk, Michael Socolich, Rama Ranganathan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fdb7e3cd099544148ee4ec803288d902
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fdb7e3cd099544148ee4ec803288d902
record_format	dspace
spelling	oai:doaj.org-article:fdb7e3cd099544148ee4ec803288d9022021-12-02T15:35:16ZLearning the pattern of epistasis linking genotype and phenotype in a protein10.1038/s41467-019-12130-82041-1723https://doaj.org/article/fdb7e3cd099544148ee4ec803288d9022019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12130-8https://doaj.org/toc/2041-1723Epistasis underlies the complexity of genotype-phenotype maps. Here, the authors analyze 8,192 mutants that link two phenotypically distinct variants of the Entacmaea quadricolor fluorescent protein, and show the existence, but also the sparsity, of high-order epistatic interactions.Frank J. PoelwijkMichael SocolichRama RanganathanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Frank J. Poelwijk Michael Socolich Rama Ranganathan Learning the pattern of epistasis linking genotype and phenotype in a protein
description	Epistasis underlies the complexity of genotype-phenotype maps. Here, the authors analyze 8,192 mutants that link two phenotypically distinct variants of the Entacmaea quadricolor fluorescent protein, and show the existence, but also the sparsity, of high-order epistatic interactions.
format	article
author	Frank J. Poelwijk Michael Socolich Rama Ranganathan
author_facet	Frank J. Poelwijk Michael Socolich Rama Ranganathan
author_sort	Frank J. Poelwijk
title	Learning the pattern of epistasis linking genotype and phenotype in a protein
title_short	Learning the pattern of epistasis linking genotype and phenotype in a protein
title_full	Learning the pattern of epistasis linking genotype and phenotype in a protein
title_fullStr	Learning the pattern of epistasis linking genotype and phenotype in a protein
title_full_unstemmed	Learning the pattern of epistasis linking genotype and phenotype in a protein
title_sort	learning the pattern of epistasis linking genotype and phenotype in a protein
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/fdb7e3cd099544148ee4ec803288d902
work_keys_str_mv	AT frankjpoelwijk learningthepatternofepistasislinkinggenotypeandphenotypeinaprotein AT michaelsocolich learningthepatternofepistasislinkinggenotypeandphenotypeinaprotein AT ramaranganathan learningthepatternofepistasislinkinggenotypeandphenotypeinaprotein
_version_	1718386635112972288

Learning the pattern of epistasis linking genotype and phenotype in a protein

Ejemplares similares