Engineering of high-precision base editors for site-specific single nucleotide replacement

Base editors can target multiple bases within a window around the target site, reducing their specificity. Here the authors engineer the connection between the deaminase and Cas domain to narrow the window of activity.

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Detalles Bibliográficos
Autores principales:	Junjie Tan, Fei Zhang, Daniel Karcher, Ralph Bock
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fdbbe85534c44830958dbe959702431b
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spelling	oai:doaj.org-article:fdbbe85534c44830958dbe959702431b2021-12-02T14:39:16ZEngineering of high-precision base editors for site-specific single nucleotide replacement10.1038/s41467-018-08034-82041-1723https://doaj.org/article/fdbbe85534c44830958dbe959702431b2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08034-8https://doaj.org/toc/2041-1723Base editors can target multiple bases within a window around the target site, reducing their specificity. Here the authors engineer the connection between the deaminase and Cas domain to narrow the window of activity.Junjie TanFei ZhangDaniel KarcherRalph BockNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Junjie Tan Fei Zhang Daniel Karcher Ralph Bock Engineering of high-precision base editors for site-specific single nucleotide replacement
description	Base editors can target multiple bases within a window around the target site, reducing their specificity. Here the authors engineer the connection between the deaminase and Cas domain to narrow the window of activity.
format	article
author	Junjie Tan Fei Zhang Daniel Karcher Ralph Bock
author_facet	Junjie Tan Fei Zhang Daniel Karcher Ralph Bock
author_sort	Junjie Tan
title	Engineering of high-precision base editors for site-specific single nucleotide replacement
title_short	Engineering of high-precision base editors for site-specific single nucleotide replacement
title_full	Engineering of high-precision base editors for site-specific single nucleotide replacement
title_fullStr	Engineering of high-precision base editors for site-specific single nucleotide replacement
title_full_unstemmed	Engineering of high-precision base editors for site-specific single nucleotide replacement
title_sort	engineering of high-precision base editors for site-specific single nucleotide replacement
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/fdbbe85534c44830958dbe959702431b
work_keys_str_mv	AT junjietan engineeringofhighprecisionbaseeditorsforsitespecificsinglenucleotidereplacement AT feizhang engineeringofhighprecisionbaseeditorsforsitespecificsinglenucleotidereplacement AT danielkarcher engineeringofhighprecisionbaseeditorsforsitespecificsinglenucleotidereplacement AT ralphbock engineeringofhighprecisionbaseeditorsforsitespecificsinglenucleotidereplacement
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Engineering of high-precision base editors for site-specific single nucleotide replacement

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