Engineering of high-precision base editors for site-specific single nucleotide replacement

Base editors can target multiple bases within a window around the target site, reducing their specificity. Here the authors engineer the connection between the deaminase and Cas domain to narrow the window of activity.

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Detalles Bibliográficos
Autores principales: Junjie Tan, Fei Zhang, Daniel Karcher, Ralph Bock
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Q
Acceso en línea:https://doaj.org/article/fdbbe85534c44830958dbe959702431b
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