Response inhibition during cue reactivity in problem gamblers: an fMRI study.

Disinhibition over drug use, enhanced salience of drug use and decreased salience of natural reinforcers are thought to play an important role substance dependence. Whether this is also true for pathological gambling is unclear. To understand the effects of affective stimuli on response inhibition i...

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Autores principales:	Ruth J van Holst, Mieke van Holstein, Wim van den Brink, Dick J Veltman, Anna E Goudriaan
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fdbd2f02c42d4db8bf8cbcf76179ba75
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spelling	oai:doaj.org-article:fdbd2f02c42d4db8bf8cbcf76179ba752021-11-18T07:23:47ZResponse inhibition during cue reactivity in problem gamblers: an fMRI study.1932-620310.1371/journal.pone.0030909https://doaj.org/article/fdbd2f02c42d4db8bf8cbcf76179ba752012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22479305/?tool=EBIhttps://doaj.org/toc/1932-6203Disinhibition over drug use, enhanced salience of drug use and decreased salience of natural reinforcers are thought to play an important role substance dependence. Whether this is also true for pathological gambling is unclear. To understand the effects of affective stimuli on response inhibition in problem gamblers (PRGs), we designed an affective Go/Nogo to examine the interaction between response inhibition and salience attribution in 16 PRGs and 15 healthy controls (HCs).Four affective blocks were presented with Go trials containing neutral, gamble, positive or negative affective pictures. The No-Go trials in these blocks contained neutral pictures. Outcomes of interest included percentage of impulsive errors and mean reaction times in the different blocks. Brain activity related to No-Go trials was assessed to measure response inhibition in the various affective conditions and brain activity related to Go trials was assessed to measure salience attribution.PRGs made fewer errors during gamble and positive trials than HCs, but were slower during all trials types. Compared to HCs, PRGs activated the dorsolateral prefrontal cortex, anterior cingulate and ventral striatum to a greater extent while viewing gamble pictures. The dorsal lateral and inferior frontal cortex were more activated in PRGs than in HCs while viewing positive and negative pictures. During neutral inhibition, PRGs were slower but similar in accuracy to HCs, and showed more dorsolateral prefrontal and anterior cingulate cortex activity. In contrast, during gamble and positive pictures PRGs performed better than HCs, and showed lower activation of the dorsolateral and anterior cingulate cortex.This study shows that gambling-related stimuli are more salient for PRGs than for HCs. PRGs seem to rely on compensatory brain activity to achieve similar performance during neutral response inhibition. A gambling-related or positive context appears to facilitate response inhibition as indicated by lower brain activity and fewer behavioural errors in PRGs.Ruth J van HolstMieke van HolsteinWim van den BrinkDick J VeltmanAnna E GoudriaanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 3, p e30909 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ruth J van Holst Mieke van Holstein Wim van den Brink Dick J Veltman Anna E Goudriaan Response inhibition during cue reactivity in problem gamblers: an fMRI study.
description	Disinhibition over drug use, enhanced salience of drug use and decreased salience of natural reinforcers are thought to play an important role substance dependence. Whether this is also true for pathological gambling is unclear. To understand the effects of affective stimuli on response inhibition in problem gamblers (PRGs), we designed an affective Go/Nogo to examine the interaction between response inhibition and salience attribution in 16 PRGs and 15 healthy controls (HCs).Four affective blocks were presented with Go trials containing neutral, gamble, positive or negative affective pictures. The No-Go trials in these blocks contained neutral pictures. Outcomes of interest included percentage of impulsive errors and mean reaction times in the different blocks. Brain activity related to No-Go trials was assessed to measure response inhibition in the various affective conditions and brain activity related to Go trials was assessed to measure salience attribution.PRGs made fewer errors during gamble and positive trials than HCs, but were slower during all trials types. Compared to HCs, PRGs activated the dorsolateral prefrontal cortex, anterior cingulate and ventral striatum to a greater extent while viewing gamble pictures. The dorsal lateral and inferior frontal cortex were more activated in PRGs than in HCs while viewing positive and negative pictures. During neutral inhibition, PRGs were slower but similar in accuracy to HCs, and showed more dorsolateral prefrontal and anterior cingulate cortex activity. In contrast, during gamble and positive pictures PRGs performed better than HCs, and showed lower activation of the dorsolateral and anterior cingulate cortex.This study shows that gambling-related stimuli are more salient for PRGs than for HCs. PRGs seem to rely on compensatory brain activity to achieve similar performance during neutral response inhibition. A gambling-related or positive context appears to facilitate response inhibition as indicated by lower brain activity and fewer behavioural errors in PRGs.
format	article
author	Ruth J van Holst Mieke van Holstein Wim van den Brink Dick J Veltman Anna E Goudriaan
author_facet	Ruth J van Holst Mieke van Holstein Wim van den Brink Dick J Veltman Anna E Goudriaan
author_sort	Ruth J van Holst
title	Response inhibition during cue reactivity in problem gamblers: an fMRI study.
title_short	Response inhibition during cue reactivity in problem gamblers: an fMRI study.
title_full	Response inhibition during cue reactivity in problem gamblers: an fMRI study.
title_fullStr	Response inhibition during cue reactivity in problem gamblers: an fMRI study.
title_full_unstemmed	Response inhibition during cue reactivity in problem gamblers: an fMRI study.
title_sort	response inhibition during cue reactivity in problem gamblers: an fmri study.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/fdbd2f02c42d4db8bf8cbcf76179ba75
work_keys_str_mv	AT ruthjvanholst responseinhibitionduringcuereactivityinproblemgamblersanfmristudy AT miekevanholstein responseinhibitionduringcuereactivityinproblemgamblersanfmristudy AT wimvandenbrink responseinhibitionduringcuereactivityinproblemgamblersanfmristudy AT dickjveltman responseinhibitionduringcuereactivityinproblemgamblersanfmristudy AT annaegoudriaan responseinhibitionduringcuereactivityinproblemgamblersanfmristudy
_version_	1718423575045603328

Response inhibition during cue reactivity in problem gamblers: an fMRI study.

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