Variation of the default mode network with altered alertness levels induced by propofol

Xiaoyuan Liu,1 Huandong Li,2 Fang Luo,1 Lei Zhang,3 Ruquan Han,1 Baoguo Wang41Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, 2Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, 3Department of Neuroradiology, Beijing Neurosurgical Institute,...

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Autores principales:	Liu XY, Li HD, Luo F, Zhang L, Han RQ, Wang BG
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/fdbe837116ae41ce9404244764b24489
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spelling	oai:doaj.org-article:fdbe837116ae41ce9404244764b244892021-12-02T05:31:05ZVariation of the default mode network with altered alertness levels induced by propofol1178-2021https://doaj.org/article/fdbe837116ae41ce9404244764b244892015-10-01T00:00:00Zhttps://www.dovepress.com/variation-of-the-default-mode-network-with-altered-alertness-levels-in-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Xiaoyuan Liu,1 Huandong Li,2 Fang Luo,1 Lei Zhang,3 Ruquan Han,1 Baoguo Wang41Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, 2Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, 3Department of Neuroradiology, Beijing Neurosurgical Institute, 4Department of Anesthesiology, Sanbo Brain Hospital, Capital Medical University, Beijing, People’s Republic of ChinaBackground: The default mode network (DMN) is closely associated with the maintenance of alertness and cognitive functions. This study aimed to observe the changes in DMN induced by increasing doses of propofol and progressively deepening sedation.Methods: Twelve healthy subjects were selected; they received target-controlled infusion of propofol (1.0 and 3.0 µg/mL of plasma) and underwent functional magnetic resonance imaging before sedation and when they achieved light and deep sedation states. The average degree, average shortest path length, global efficiency, local efficiency, and clustering coefficient of DMN were assessed to study the overall and internal changes of DMN with gradual changes in alertness level, as well as the relationship between thalamus and DMN. Meanwhile, basic vital signs and respiratory inhibition were recorded.Results: DMN parameters were gradually inhibited with decreasing level of alertness, the differences were significant between light sedation and awake states (all P<0.01), but not between deep and light sedation states. However, the shortest path lengths of the posterior cingulate cortex, medial prefrontal cortex, and lateral parietal cortexes in the DMN were significantly increased under deep sedation.Conclusion: Overall, DMN is propofol-sensitive. A small dose of propofol can significantly inhibit the DMN, affecting the level of alertness. The posterior cingulate cortex, medial prefrontal cortex, and lateral parietal cortexes in the DMN are less sensitive to propofol, and could be significantly inhibited by a higher concentration of propofol, further reducing the level of alertness.Keywords: default mode network, propofol, functional connectivity, sedation, anesthesiaLiu XYLi HDLuo FZhang LHan RQWang BGDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2015, Iss default, Pp 2573-2581 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Liu XY Li HD Luo F Zhang L Han RQ Wang BG Variation of the default mode network with altered alertness levels induced by propofol
description	Xiaoyuan Liu,1 Huandong Li,2 Fang Luo,1 Lei Zhang,3 Ruquan Han,1 Baoguo Wang41Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, 2Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, 3Department of Neuroradiology, Beijing Neurosurgical Institute, 4Department of Anesthesiology, Sanbo Brain Hospital, Capital Medical University, Beijing, People’s Republic of ChinaBackground: The default mode network (DMN) is closely associated with the maintenance of alertness and cognitive functions. This study aimed to observe the changes in DMN induced by increasing doses of propofol and progressively deepening sedation.Methods: Twelve healthy subjects were selected; they received target-controlled infusion of propofol (1.0 and 3.0 µg/mL of plasma) and underwent functional magnetic resonance imaging before sedation and when they achieved light and deep sedation states. The average degree, average shortest path length, global efficiency, local efficiency, and clustering coefficient of DMN were assessed to study the overall and internal changes of DMN with gradual changes in alertness level, as well as the relationship between thalamus and DMN. Meanwhile, basic vital signs and respiratory inhibition were recorded.Results: DMN parameters were gradually inhibited with decreasing level of alertness, the differences were significant between light sedation and awake states (all P<0.01), but not between deep and light sedation states. However, the shortest path lengths of the posterior cingulate cortex, medial prefrontal cortex, and lateral parietal cortexes in the DMN were significantly increased under deep sedation.Conclusion: Overall, DMN is propofol-sensitive. A small dose of propofol can significantly inhibit the DMN, affecting the level of alertness. The posterior cingulate cortex, medial prefrontal cortex, and lateral parietal cortexes in the DMN are less sensitive to propofol, and could be significantly inhibited by a higher concentration of propofol, further reducing the level of alertness.Keywords: default mode network, propofol, functional connectivity, sedation, anesthesia
format	article
author	Liu XY Li HD Luo F Zhang L Han RQ Wang BG
author_facet	Liu XY Li HD Luo F Zhang L Han RQ Wang BG
author_sort	Liu XY
title	Variation of the default mode network with altered alertness levels induced by propofol
title_short	Variation of the default mode network with altered alertness levels induced by propofol
title_full	Variation of the default mode network with altered alertness levels induced by propofol
title_fullStr	Variation of the default mode network with altered alertness levels induced by propofol
title_full_unstemmed	Variation of the default mode network with altered alertness levels induced by propofol
title_sort	variation of the default mode network with altered alertness levels induced by propofol
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/fdbe837116ae41ce9404244764b24489
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Variation of the default mode network with altered alertness levels induced by propofol

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