Stimulatory Effect of Intermittent Hypoxia on the Production of Corticosterone by Zona Fasciculata-Reticularis Cells in Rats

Abstract Hypoxia or intermittent hypoxia (IH) have known to alter both synthesis and secretion of hormones. However, the effect of IH on the production of adrenal cortical steroid hormones is still unclear. The aim of present study was to explore the mechanism involved in the effect of IH on the pro...

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Autores principales:	Guey-Shyang Hwang, Chih-Chieh Chen, Jou-Chun Chou, Ling-Ling Chang, Shu-Fen Kan, Wei-Ho Lai, Fu-Kong Lieu, Sindy Hu, Paulus S. Wang, Shyi-Wu Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fdbff8c123f9477dbc3336a723ca06da
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spelling	oai:doaj.org-article:fdbff8c123f9477dbc3336a723ca06da2021-12-02T16:06:23ZStimulatory Effect of Intermittent Hypoxia on the Production of Corticosterone by Zona Fasciculata-Reticularis Cells in Rats10.1038/s41598-017-07054-62045-2322https://doaj.org/article/fdbff8c123f9477dbc3336a723ca06da2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07054-6https://doaj.org/toc/2045-2322Abstract Hypoxia or intermittent hypoxia (IH) have known to alter both synthesis and secretion of hormones. However, the effect of IH on the production of adrenal cortical steroid hormones is still unclear. The aim of present study was to explore the mechanism involved in the effect of IH on the production of corticosterone by rat ZFR cells. Male rats were exposed at 12% O2 and 88% N2 (8 hours per day) for 1, 2, or 4 days. The ZFR cells were incubated at 37 °C for 1 hour with or without ACTH, 8-Br-cAMP, calcium ion channel blockers, or steroidogenic precursors. The concentration of plasma corticosterone was increased time-dependently by administration of IH hypoxia. The basal levels of corticosterone production in cells were higher in the IH groups than in normoxic group. IH resulted in a time-dependent increase of corticosterone production in response to ACTH, 8-Br-cAMP, progesterone and deoxycorticosterone. The production of pregnenolone in response to 25-OH-C and that of progesterone in response to pregnenolone in ZFR cells were enhanced by 4-day IH. These results suggest that IH in rats increases the secretion of corticosterone via a mechanism at least in part associated with the activation of cAMP pathway and steroidogenic enzymes.Guey-Shyang HwangChih-Chieh ChenJou-Chun ChouLing-Ling ChangShu-Fen KanWei-Ho LaiFu-Kong LieuSindy HuPaulus S. WangShyi-Wu WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Guey-Shyang Hwang Chih-Chieh Chen Jou-Chun Chou Ling-Ling Chang Shu-Fen Kan Wei-Ho Lai Fu-Kong Lieu Sindy Hu Paulus S. Wang Shyi-Wu Wang Stimulatory Effect of Intermittent Hypoxia on the Production of Corticosterone by Zona Fasciculata-Reticularis Cells in Rats
description	Abstract Hypoxia or intermittent hypoxia (IH) have known to alter both synthesis and secretion of hormones. However, the effect of IH on the production of adrenal cortical steroid hormones is still unclear. The aim of present study was to explore the mechanism involved in the effect of IH on the production of corticosterone by rat ZFR cells. Male rats were exposed at 12% O2 and 88% N2 (8 hours per day) for 1, 2, or 4 days. The ZFR cells were incubated at 37 °C for 1 hour with or without ACTH, 8-Br-cAMP, calcium ion channel blockers, or steroidogenic precursors. The concentration of plasma corticosterone was increased time-dependently by administration of IH hypoxia. The basal levels of corticosterone production in cells were higher in the IH groups than in normoxic group. IH resulted in a time-dependent increase of corticosterone production in response to ACTH, 8-Br-cAMP, progesterone and deoxycorticosterone. The production of pregnenolone in response to 25-OH-C and that of progesterone in response to pregnenolone in ZFR cells were enhanced by 4-day IH. These results suggest that IH in rats increases the secretion of corticosterone via a mechanism at least in part associated with the activation of cAMP pathway and steroidogenic enzymes.
format	article
author	Guey-Shyang Hwang Chih-Chieh Chen Jou-Chun Chou Ling-Ling Chang Shu-Fen Kan Wei-Ho Lai Fu-Kong Lieu Sindy Hu Paulus S. Wang Shyi-Wu Wang
author_facet	Guey-Shyang Hwang Chih-Chieh Chen Jou-Chun Chou Ling-Ling Chang Shu-Fen Kan Wei-Ho Lai Fu-Kong Lieu Sindy Hu Paulus S. Wang Shyi-Wu Wang
author_sort	Guey-Shyang Hwang
title	Stimulatory Effect of Intermittent Hypoxia on the Production of Corticosterone by Zona Fasciculata-Reticularis Cells in Rats
title_short	Stimulatory Effect of Intermittent Hypoxia on the Production of Corticosterone by Zona Fasciculata-Reticularis Cells in Rats
title_full	Stimulatory Effect of Intermittent Hypoxia on the Production of Corticosterone by Zona Fasciculata-Reticularis Cells in Rats
title_fullStr	Stimulatory Effect of Intermittent Hypoxia on the Production of Corticosterone by Zona Fasciculata-Reticularis Cells in Rats
title_full_unstemmed	Stimulatory Effect of Intermittent Hypoxia on the Production of Corticosterone by Zona Fasciculata-Reticularis Cells in Rats
title_sort	stimulatory effect of intermittent hypoxia on the production of corticosterone by zona fasciculata-reticularis cells in rats
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/fdbff8c123f9477dbc3336a723ca06da
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Stimulatory Effect of Intermittent Hypoxia on the Production of Corticosterone by Zona Fasciculata-Reticularis Cells in Rats

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