Corneal ectasia in mothers of Down syndrome children

Abstract In this study, corneal findings regarding keratoconus (KC) and early KC among mothers with Down syndrome children (MDS) and a group of age-at-delivery-matched mothers with normal children (MNC) were compared. KC was diagnosed based on the presence of a clinical sign and at least one abnorma...

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Autores principales:	Hassan Hashemi, Soheila Asgari, Parsa Panahi, Shiva Mehravaran, Akbar Fotouhi, Renato Ambrósio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fdc0c680ae6f49a4abcc4145e9da7555
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spelling	oai:doaj.org-article:fdc0c680ae6f49a4abcc4145e9da75552021-11-21T12:23:15ZCorneal ectasia in mothers of Down syndrome children10.1038/s41598-021-02035-22045-2322https://doaj.org/article/fdc0c680ae6f49a4abcc4145e9da75552021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02035-2https://doaj.org/toc/2045-2322Abstract In this study, corneal findings regarding keratoconus (KC) and early KC among mothers with Down syndrome children (MDS) and a group of age-at-delivery-matched mothers with normal children (MNC) were compared. KC was diagnosed based on the presence of a clinical sign and at least one abnormal tomographic or biomechanical criterion. Early KC was defined as having no clinical sign in the presence of at least one abnormal tomographic or biomechanical criterion. The normal subgroups in each group were compared in terms tomographic and biomechanical parameters. In MDS and MNC, the prevalence rates were 6.5% and 1.6% for KC (P = 0.047), and 30.9% and 14.3% for early KC (P = 0.014), respectively. Comparison between the two normal subgroups showed significant differences in mean index of height asymmetry, irregularity index, anterior asphericity, pentacam random forest index, corneal stiffness parameters at first applanation, deformation amplitude ratios, integrated radius-1 mm, highest concavity deflection amplitude, biomechanical corrected IOP, peak distance, and radius (all P < 0.05). This study showed that MDS are more likely to have KC and also to have thinner, steeper and softer corneas compared to MNC. This results support the need for further work for determining the risk of delivering a child with DS.Hassan HashemiSoheila AsgariParsa PanahiShiva MehravaranAkbar FotouhiRenato AmbrósioNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hassan Hashemi Soheila Asgari Parsa Panahi Shiva Mehravaran Akbar Fotouhi Renato Ambrósio Corneal ectasia in mothers of Down syndrome children
description	Abstract In this study, corneal findings regarding keratoconus (KC) and early KC among mothers with Down syndrome children (MDS) and a group of age-at-delivery-matched mothers with normal children (MNC) were compared. KC was diagnosed based on the presence of a clinical sign and at least one abnormal tomographic or biomechanical criterion. Early KC was defined as having no clinical sign in the presence of at least one abnormal tomographic or biomechanical criterion. The normal subgroups in each group were compared in terms tomographic and biomechanical parameters. In MDS and MNC, the prevalence rates were 6.5% and 1.6% for KC (P = 0.047), and 30.9% and 14.3% for early KC (P = 0.014), respectively. Comparison between the two normal subgroups showed significant differences in mean index of height asymmetry, irregularity index, anterior asphericity, pentacam random forest index, corneal stiffness parameters at first applanation, deformation amplitude ratios, integrated radius-1 mm, highest concavity deflection amplitude, biomechanical corrected IOP, peak distance, and radius (all P < 0.05). This study showed that MDS are more likely to have KC and also to have thinner, steeper and softer corneas compared to MNC. This results support the need for further work for determining the risk of delivering a child with DS.
format	article
author	Hassan Hashemi Soheila Asgari Parsa Panahi Shiva Mehravaran Akbar Fotouhi Renato Ambrósio
author_facet	Hassan Hashemi Soheila Asgari Parsa Panahi Shiva Mehravaran Akbar Fotouhi Renato Ambrósio
author_sort	Hassan Hashemi
title	Corneal ectasia in mothers of Down syndrome children
title_short	Corneal ectasia in mothers of Down syndrome children
title_full	Corneal ectasia in mothers of Down syndrome children
title_fullStr	Corneal ectasia in mothers of Down syndrome children
title_full_unstemmed	Corneal ectasia in mothers of Down syndrome children
title_sort	corneal ectasia in mothers of down syndrome children
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fdc0c680ae6f49a4abcc4145e9da7555
work_keys_str_mv	AT hassanhashemi cornealectasiainmothersofdownsyndromechildren AT soheilaasgari cornealectasiainmothersofdownsyndromechildren AT parsapanahi cornealectasiainmothersofdownsyndromechildren AT shivamehravaran cornealectasiainmothersofdownsyndromechildren AT akbarfotouhi cornealectasiainmothersofdownsyndromechildren AT renatoambrosio cornealectasiainmothersofdownsyndromechildren
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Corneal ectasia in mothers of Down syndrome children

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