Negative linkage disequilibrium between amino acid changing variants reveals interference among deleterious mutations in the human genome.

Evolutionary forces like Hill-Robertson interference and negative epistasis can lead to deleterious mutations being found on distinct haplotypes. However, the extent to which these forces depend on the selection and dominance coefficients of deleterious mutations and shape genome-wide patterns of li...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Jesse A Garcia, Kirk E Lohmueller
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
Materias:
Acceso en línea:https://doaj.org/article/fdc20550f1474d898c3d0170407f140c
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!