Retinal Artery Contraction After Phenylephrine as a Cardiovascular Risk Biomarker

Alfonso Casado, Alicia López-de-Eguileta, Soraya Fonseca, Andrea Cerveró, Jorge Gaitán Department of Ophthalmology, Hospital Universitario Marqués de Valdecilla, Santander, SpainCorrespondence: Jorge GaitánOphthalmology Department, Hospital Marq...

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Autores principales:	Casado A, López-de-Eguileta A, Fonseca S, Cerveró A, Gaitán J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	choroidal thickness peripapillary choroidal thickness retinal nerve fiber layer phenylephrine Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/fdc2b4da848a4e2b88b7ab6346055752
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spelling	oai:doaj.org-article:fdc2b4da848a4e2b88b7ab63460557522021-12-02T09:48:11ZRetinal Artery Contraction After Phenylephrine as a Cardiovascular Risk Biomarker1177-5483https://doaj.org/article/fdc2b4da848a4e2b88b7ab63460557522020-05-01T00:00:00Zhttps://www.dovepress.com/retinal-artery-contraction-after-phenylephrine-as-a-cardiovascular-ris-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Alfonso Casado, Alicia López-de-Eguileta, Soraya Fonseca, Andrea Cerveró, Jorge Gaitán Department of Ophthalmology, Hospital Universitario Marqués de Valdecilla, Santander, SpainCorrespondence: Jorge GaitánOphthalmology Department, Hospital Marqués de Valdecilla, Av. Valdecilla, 25, Santander 39008, Cantabria, SpainTel +34 605762803Email jorgegaitanv@gmail.comBackground and Aim: We investigated the in vivo changes of artery diameter (AD) and vein diameter (VD) after topical phenylephrine 2.5% instillation, and its relationship with the Systematic Coronary Risk Evaluation (SCORE).Methods: This is a cross-sectional study. Healthy control patients were included. All of the participants underwent enhanced depth imaging by spectral-domain optical coherence tomography before and 30 minutes after phenylephrine instillation, using eye-tracking and follow-up software. Changes in AD and VD were assessed.Results: The study included 45 eyes of 45 patients (14 males and 31 females). The mean age was 58.6 ± 15.1 years (26– 88 years). Mean SCORE risk estimation value was 2.0 (0– 14). No significant correlation was found between pre-phenylephrine AD or VD with age (p=0.237 and p=0.821, respectively), SCORE (p=0.545 and p=0.723, respectively). AD significant thinned after phenylephrine (p< 0.001), whereas no significant changes could be depicted in VD (p=0.474). Changes in AD after phenylephrine were significantly related with SCORE risk estimation (p=0.035). Discordantly, changes in VD after phenylephrine were not significantly related with SCORE (p=0.505).Conclusion: As a significant thinning of AD occurred following phenylephrine instillation, and as the magnitude of this thinning is related with SCORE, it is useful to test the retinal artery contraction to infer the cardiovascular health status.Keywords: choroidal thickness, peripapillary choroidal thickness, retinal nerve fiber layer, phenylephrineCasado ALópez-de-Eguileta AFonseca SCerveró AGaitán JDove Medical Pressarticlechoroidal thicknessperipapillary choroidal thicknessretinal nerve fiber layerphenylephrineOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 1269-1275 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	choroidal thickness peripapillary choroidal thickness retinal nerve fiber layer phenylephrine Ophthalmology RE1-994
spellingShingle	choroidal thickness peripapillary choroidal thickness retinal nerve fiber layer phenylephrine Ophthalmology RE1-994 Casado A López-de-Eguileta A Fonseca S Cerveró A Gaitán J Retinal Artery Contraction After Phenylephrine as a Cardiovascular Risk Biomarker
description	Alfonso Casado, Alicia López-de-Eguileta, Soraya Fonseca, Andrea Cerveró, Jorge Gaitán Department of Ophthalmology, Hospital Universitario Marqués de Valdecilla, Santander, SpainCorrespondence: Jorge GaitánOphthalmology Department, Hospital Marqués de Valdecilla, Av. Valdecilla, 25, Santander 39008, Cantabria, SpainTel +34 605762803Email jorgegaitanv@gmail.comBackground and Aim: We investigated the in vivo changes of artery diameter (AD) and vein diameter (VD) after topical phenylephrine 2.5% instillation, and its relationship with the Systematic Coronary Risk Evaluation (SCORE).Methods: This is a cross-sectional study. Healthy control patients were included. All of the participants underwent enhanced depth imaging by spectral-domain optical coherence tomography before and 30 minutes after phenylephrine instillation, using eye-tracking and follow-up software. Changes in AD and VD were assessed.Results: The study included 45 eyes of 45 patients (14 males and 31 females). The mean age was 58.6 ± 15.1 years (26– 88 years). Mean SCORE risk estimation value was 2.0 (0– 14). No significant correlation was found between pre-phenylephrine AD or VD with age (p=0.237 and p=0.821, respectively), SCORE (p=0.545 and p=0.723, respectively). AD significant thinned after phenylephrine (p< 0.001), whereas no significant changes could be depicted in VD (p=0.474). Changes in AD after phenylephrine were significantly related with SCORE risk estimation (p=0.035). Discordantly, changes in VD after phenylephrine were not significantly related with SCORE (p=0.505).Conclusion: As a significant thinning of AD occurred following phenylephrine instillation, and as the magnitude of this thinning is related with SCORE, it is useful to test the retinal artery contraction to infer the cardiovascular health status.Keywords: choroidal thickness, peripapillary choroidal thickness, retinal nerve fiber layer, phenylephrine
format	article
author	Casado A López-de-Eguileta A Fonseca S Cerveró A Gaitán J
author_facet	Casado A López-de-Eguileta A Fonseca S Cerveró A Gaitán J
author_sort	Casado A
title	Retinal Artery Contraction After Phenylephrine as a Cardiovascular Risk Biomarker
title_short	Retinal Artery Contraction After Phenylephrine as a Cardiovascular Risk Biomarker
title_full	Retinal Artery Contraction After Phenylephrine as a Cardiovascular Risk Biomarker
title_fullStr	Retinal Artery Contraction After Phenylephrine as a Cardiovascular Risk Biomarker
title_full_unstemmed	Retinal Artery Contraction After Phenylephrine as a Cardiovascular Risk Biomarker
title_sort	retinal artery contraction after phenylephrine as a cardiovascular risk biomarker
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/fdc2b4da848a4e2b88b7ab6346055752
work_keys_str_mv	AT casadoa retinalarterycontractionafterphenylephrineasacardiovascularriskbiomarker AT lopezdeeguiletaa retinalarterycontractionafterphenylephrineasacardiovascularriskbiomarker AT fonsecas retinalarterycontractionafterphenylephrineasacardiovascularriskbiomarker AT cerveroa retinalarterycontractionafterphenylephrineasacardiovascularriskbiomarker AT gaitanj retinalarterycontractionafterphenylephrineasacardiovascularriskbiomarker
_version_	1718398042743242752

Retinal Artery Contraction After Phenylephrine as a Cardiovascular Risk Biomarker

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